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师资队伍
邢述
基本情况
姓名: 邢述
性别:
职称: 教授
最高学历: 研究生
最高学位: 博士
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详细情况
所研究方向: 近年来一直从事蛋白质酪氨酸激酶(PTKs)及磷酸酶(PTPs)的结构与功能的研究,首次发现骨髓增殖性肿瘤(MPNs)患者体内蛋白质酪氨酸激酶JAK2发生V617F突变,并最先应用JAK2V617F转基因小鼠模型证明了JAK2V617F是导致MPNs的主要原因。目前的研究方向:1、JAK2V617F阴性MPNs发病机理的研究;2、PTKs与PTPs相互作用的研究;3、PTKs与PTPs的基因多态性与某些疾病患病风险的研究;4、PTKs与PTPs突变与癌症相关性的研究;5、PTPs选择性抑制剂的筛选。
教育经历: 2003.9~2008.12 吉林大学生命科学院 博士研究生
2000.9~2003.6 吉林大学生命科学院 硕士研究生
1996.9~2000.6 吉林大学生命科学院 本 科 生
工作经历: 2005.8~2008.9 美国俄克拉荷马大学生命健康科学研究中心 访问学者
2005.2~2005.7 美国范德比尔特大学医学中心 访问学者
2003.7~2006.9 吉林大学生命科学院 助 教
2006.9~2010.9 吉林大学生命科学院 讲 师
2010.9~至 今 吉林大学生命科学院 副 教 授
学术论文: PUBLICATIONS
1. Lu L, Gao X, Zhu M, Wang S, Wu Q, Xing S*, Fu X, Liu Z, Guo M. Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases. Biometals. 2012 Jun; 25(3): 599-610.
2. Wang Q, Zhu M, Zhu R, Lu L, Yuan C, Xing S, Fu X, Mei Y, Hang Q. Exploration of α-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases. Eur J Med Chem. 2012 Mar; 49: 354-64.
3. Yuan C, Zhu M, Wang Q, Lu L, Xing S, Fu X, Jiang Z, Zhang S, Li Z, Li Z, Zhu R, Ma L, Xu L. Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(ii) complex. Chem Commun (Camb). 2012 Jan 4; 48(8):1153-5.
4. Wang Q, Zhu M, Lu L, Yuan C, Xing S, Fu X. Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization and biological activities. Dalton Trans. 2011 Dec 28; 40(48): 12926-34.
5. Li Y, Lu L, Zhu M, Wang Q, Yuan C, Xing S, Fu X, Mei Y. Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives. Biometals. 2011 Dec; 24(6): 993-1004.
6. Ma L, Lu L, Zhu M, Wang Q, Gao F, Yuan C, Wu Y, Xing S, Fu X, Mei Y, Gao X. Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases. J Inorg Biochem. 2011 Sep; 105(9):1138-47.
7. Ma L, Lu L, Zhu M, Wang Q, Li Y, Xing S, Fu X, Gao Z, Dong Y. Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases. Dalton Trans. 2011 Jun 28; 40(24):6532-40.
8. Ma J, Li Z, Xing S, Ho WT, Fu X, Zhao ZJ. Tea contains potent inhibitors of tyrosine phosphatase PTP1B. Biochem Biophys Res Commun. 2011 Apr 1; 407(1): 98-102.
9. Zhao W, Gao R, Lee J, Xing S, Ho WT, Fu X, Li S, Zhao ZJ. Relevance of JAK2V617F positivity to hematological diseases--survey of samples from a clinical genetics laboratory. J Hematol Oncol. 2011 Jan 14; 4: 4.
10. Yuan C, Lu L, Wu Y, Liu Z, Guo M, Xing S, Fu X, Zhu M. Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives. J Inorg Biochem. 2010 Sep; 104(9): 978-86.
11. Lu L, Wang S, Zhu M, Liu Z, Guo M, Xing S, Fu X. Inhibition protein tyrosine phosphatases by an oxovanadium glutamate complex, Na(2)[VO(Glu) (2)(CH (3)OH)](Glu = glutamate). Biometals. 2010 Dec; 23(6):1139-47.
12. Zhang X, Xing S, Wu X, Lin F, Fu X, Li W. Purification and characterization of protein tyrosine phosphatase MEG1 and preparation of anti-PTPMEG1 antibody. Chem Res Chinese U. 2010, 26(4): 591-95
13. Xing S, Ho WT, Zhao W, Ma J, Wang S, Xu X, Li Q, Fu X, Xu M, Zhao ZJ. Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice. Blood. 2008 May 15; 111(10): 5109-17.
14. Li Z, Xing S, Wang S, Ho WT, Zhao ZJ. Characterization of a highly effective protein substrate for analysis of JAK2 (V617F) activity. Exp Hematol., 2007 Nov; 35(11): 1624-32.
15. Li Z, Xu M, Xing S, Ho WT, Ishii T, Li Q, Fu X, Zhao ZJ. Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth. J Biol Chem. 2007 Feb 9; 282(6): 3428-32.
16. Xu X, Zhang Q, Luo J, Xing S, Li Q, Krantz SB, Fu X, Zhao ZJ. JAK2(V617F): prevalence in a large Chinese hospital population. Blood. 2007 Jan 1; 109(1): 339-42.
17. Zhao R, Xing S, Li Z, Fu X, Li Q, Krantz SB, Zhao ZJ. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005 Jun 17; 280(24): 22788-92.

MEETING ABSTRACTS
1. Wanming Zhao, Shu Xing, Rufei Gao, Aref Al-Kali, Wanting Tina Ho and Zhizhuang Joe Zhao. Generation and Characterization of Transgenic Mice Expressing MplW515L. Poster Session. The 51st ASH annual meeting, 2009, New Orleans, LA, USA.
2. Shu Xing, Wanming Zhao, Wanting Tina Ho and Zhizhuang Joe Zhao. Transgenic Expression of Wild Type JAK2 Suppresses Myeloproliferative Disorder Phenotypes Induced by Mutant JAK2V617F in Mice. Oral Session. The 50th ASH annual meeting, 2008, San Francisco, CA, USA.
3. Shu Xing and Zhizhuang Joe Zhao. Transgenic Expression of JAK2V617F Causes Myeloproliferative Disorders in Mice. Poster Session. The 49th ASH annual meeting, 2007, Atlanta, GA, USA.

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