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孔维
基本情况
姓名: 孔维
性别:
职务: 院长
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
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详细情况
所在学科专业: 分子生物学
所研究方向: HIV,HPV,HEV,EV71等流行病学和病理研究,疫苗构建和评价。
教育经历: 1983.9至1988.7 吉林大学生物化学专业本科
1988.9至1991.7 吉林大学生物化学专业硕士生
1991.9至1994.7 吉林大学生物化学专业博士生
工作经历: 1995.9至1999.7 美国Johns Hopkins大学医学院博士后
1999.7至2002.2 美国Johns Hopkins大学公共卫生学院 助理研究员
2002.2至现在 吉林大学生命科学学院教授/博士生导师
2008至现在 吉林大学艾滋病疫苗国家工程实验室主任
科研项目: 近五年来,作为项目负责人承担国家“十一五”重大专项1项,国家“十二五”重大专项一项,国家863项目4项,国家自然科学基金4项,国际合作项目1项,省科委项目2项。
学术论文: 近期发表论文90余篇,申请13项发明专利,其中2项已授权。
近五年发表的代表性文章:
1. Mingyu Lv, Jiawen Wang, Yingzi Zhu, Xiaodan Wang, Tao Zuo, Donglai Liu, Jingyao Zhang, Jiaxin Wu, Haihong Zhang, Wei Kong, Xianghui Yu, Overexpression of inactive tetherin delGPI mutant inhibits HIV-1 Vpu-mediated antagonism of endogenous tetherin, FEBS Letters 587 (2013) 37–43. (IF 3.538)
2. Bo Sun, XiangHui Yu, Wei Kong, Shiyang Sun, Ping Yang, Changlin Zhu, Haihong Zhang, Yongge Wu, Yan Chen, Yuhua Shi, Xizhen Zhang, Chunlai Jiang, Production of influenza H1N1 vaccine from MDCK cells using a novel disposable packed-bed bioreactor, Appl Microbiol Biotechnol, DOI 10.1007/s00253-012-4375-7 (IF 3.425 )
3. Bin Yu, Jianing Dong, Chu Wang, Yang Zhan, Haihong Zhang, Jiaxin Wu, Wei Kong, Xianghui Yu, Characteristics of neutralizing antibodies to adenovirus capsid proteins in human and animal sera, Virology 437 (2013) 118–123. (IF 3.351)
4. Yu-Qian Wang, Hai-Hong Zhang, Chen-Lu Liu, Qiu Xia, Hui Wu, Xiang-Hui Yu, Wei Kong, Correlation Between Auto-antibodies to Survivin and MUC1 Variable Number Tandem Repeats in Colorectal Cancer, Asian Pacific Journal of Cancer Prevention, Vol 13, 2012,5557-5562. (IF 0.659)
5. Tao Zuo, Donglai Liu, Wei Lv, Xiaodan Wang, Jiawen Wang, Mingyu Lv, Wenlin Huang, Jiaxin Wu, Haihong Zhang, Hongwei Jin, Liangren Zhang, Wei Kong and Xianghui Yu, Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC, Journal of Virology, 2012, 86(10):5497-5507.(IF2010: 5.189 )
6. Haihong Zhang, Yuqian Wang, Chenlu Liu, Lixing Zhang, Qiu Xia, Yong Zhang, Jiaxin Wu, Chunlai Jiang, Yan Chen, Yongge Wu, Xiao Zha, Xianghui Yu, Wei Kong, DNA and adenovirus tumor vaccine expressing truncated survivin generates specific immune responses and anti-tumor effects in a murine melanoma model, Cancer Immunol Immunother (2012) 61:1857–1867. (IF 3.701)
7. Wei wei, Zheng Hu, Hanjing Fu, Yi Tie, Haihong Zhang, Yongge Wu and Xaiofei Zheng, MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells, ONCOLOGY REPORTS 28: 701-706, 2012. (IF 1.835)
8. Bin Yu, Chu Wang, Jianing Dong, Min Zhang, Haihong Zhang, Jiaxin Wu, Yuqing Wu,Wei Kong, Xianghui Yu, Chimeric hexon HVRs protein reflects partial function of adenovirus, Biochemical and Biophysical Research Communications, 421 (2012) 170–176.(IF2010: 2.595)
9. Bin Yu, Yan Zhou, Hao Wu, Zhen Wang, Yang Zhan, Xiao Feng, Ranshen Geng, Yongge Wu,,Wei Kong, Xianghui Yu, Seroprevalence of Neutralizing Antibodies to Human Adenovirus Type 5 in Healthy Adults in China, Journal of Medical Virology 84:1408–1414 (2012). (IF2010: 2.895)
10. Q. You, C. Jiang, Y. Wu, X. Yu, Y. Chen, X. Zhang, W. Wei, Y. Wang, Z. Tang, D. Jiang,Y. Wu, C. Wang, X. Meng, X. Zhao, W. Kong, Subcutaneous administration of modified vaccinia virus Ankara expressing an Ag85B-ESAT6 fusion protein, but not an adenovirus-based vaccine, protects mice against intravenous challenge with Mycobacterium tuberculosis (SJI-11-224), Scandinavian Journal of Immunology 75, 77-84. (IF 1.935)
11. Qingrui You, Yongge Wu, Dehua Jiang, Yang Wu, Changyong Wang, Wei Wei, Xianghui Yu, Xizhen Zhang, Wei Kong, Chunlai Jiang, Immune responses induced by heterologous boosting of recombinant Bacillus Calmette-Guerin(rBCG) with Ag85B-ESAT6 fusion protein in levamisole based adjuvant, Immunological Investigations, 2012; 41(4): 412–428. (IF 1.27)
12. Qingrui You, Chunlai Jiang, Wei Kong and Yongge Wu, Attempted Immunotherapy For Mycobacterium Tuberculosis With Viral and Protein Vaccines Based on AG85B-ESAT6 in a Mouse Model, Acta Microbiologica et Immunologica Hungarica, 59 (1), pp. 63–75 (2012).
13. Ye Duan, Tiejun Gu, Chunlai Jiang, Ruosen Yuan, Huafei Zhang, Hongjia Hou, Xianghui Yu, Yan Chen, Yong Zhang, Yongge Wu, Wei Kong, Molecular Immunology, accepted.(IF:2.916)
14. Mengshu Wang, Bingxue Sun, Jiao Feng, Haihong Zhang, Bin Liu, Chun Li, Yan Chen, Yong Zhang, Weikong, Investigation of Transport Mechanism of Exendin-4 arcoss MDCK and MDCK MDR1 Cell Monolayers, Biol.Pharm. Bull, 35(5) 745–752 (2012). (IF2010:1.811)
15. Qingguang Dong, Yong Zhang, Mengshu Wang, Jiao Feng, Haihong, Zhang, Yan Chen, Wei Li, Wei Kong, Effect of multiple N-methylation of deuterohemin-peptide conjugates on their activity, enzymatic stability and intestinal permeability, Amino Acid, accepted. (IF 4.106)
16. ZHANG XiZhen, WANG XiaoDan, ZHAO DongHai, MENG XiangYu, ZHAO XingHong, YU XiangHui, KONG Wei, Design and immunogenicity assessment of HIV-1 virus-like particles as a candidate vaccine, SCIENCE CHINA Life Sciences, November 2011 Vol.54 No.11: 1042–1047.(IF 1.345)
17. Mingyu Lv, Jiawen Wang, Xiaodan Wang, Tao Zuo, Yingzi Zhu, Wei Kong, Xianghui Yu,Polarity Changes in the Transmembrane Domain Core of HIV-1 Vpu Inhibits Its Anti-Tetherin Activity,PLOSONE,June 2011,Volume 6,Issue 6,e20890。(IF 4.41)
18. Jiawen Wang, Wenyan Zhang, Mingyu Lv, Tao Zuo, Wei Kong, Xianghui Yu, Identification of a Cullin5-ElonginB- ElonginC E3 Complex in degradation of FIV vif-mediated feline APOBEC3 proteins, Journal of Virology, Dec. 2011, p. 12482-12491.(IF 5.189)
19. BINYU, YU ZHANG, YANGZHAN, XIAOZHA, YONEGEWU, XIZHENZHANG, QINGZHEDONG, WEI KONG, XIANGHUI YU, Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects,oncology reports,26: 255-264, 2011。(IF 1.686)
20. Yang Gao, Min Zhang, Huafei Zhang, Xianghui Yu, Wei Kong, Xiao Zha, Yuqing Wu,Thermal Stability and Structural Variations of Survivin and Its Deletants in Aqueous Solution as Revealed by Spectroscopy,The Journal of Physical Chemistry B,2011, 115, 7038–7044。(IF 3.602)
21. Yudi Wang, Qiujia Shao, Xianghui Yu, Wei Kong, James E.K. Hildreth, Bindong Liu,N-terminal HA tag renders lysine-deficient APOBEC3G 1 resistant to HIV-12 Vif induced degradation by reduced polyubiquitination,J. Virol. doi:10.1128/JVI.01925-10。(IF 5.189)
22. Tie-jun Gu, Wei Wei, Ye Duan, Chun-lai Jiang, Yan Chen, Xiang-hui Yu, Jia-xin Wu, Yong-ge Wu, Wei Kong, Identification of Binding Epitope for Anti-Rabies Virus Glycoprotein Single-Chain Fv Fragment FV57, Protein & Peptide Letters, 2011,18(11),1099-1106. (IF 1.848)
23. Yang Gao, Huafei Zhang, Min Zhang, Haihong Zhang, Xianghui Yu, Wei Kong, Xiao Zha, Yuqing Wu,N-terminal deletion effects of human survivin on dimerization and binding to Smac/DIABLO in vitro,The Journal of Physical Chemistry, B 2010, 114, 15656–15662。(IF 3.602)
24. Bin LIU, Qingguang DONG, Mengshu WANG, Lin SHI, Yongge WU, Xianghui YU, Yanyu SHI, Yaming SHAN, Chunlai JIANG, Xizhen ZHANG, Tiejun GU, Yan CHEN, Wei KONG, Preparation, Characterization, and Pharmacodynamics of Exenatide-Loaded Poly(DL-lactic-co-glycolic acid) Microspheres, Chem. Pharm. Bull., 58(11),1474-1479, November 2010. (IF1.698)
25. Hongxia Ma, Xiaoguo Song, Zhuo Li, Tim J Harrison, Heqiu Zhang, Wa Hao, Weijin Huang, Jiming Yin, Yan Yan, Wei Kong, Youchun Wang. Varying abilities of recombinant polypeptides from different regions of hepatitis E virus ORF2 and ORF3 to detect anti-HEV immunoglobulin M. Journal of Medical Virology. 2009; 81(6): 1052-1061.(2.779)
26. Hongxia Ma, Xiaoguo Song, Tim J. Harrison, Rongcheng Li, Guoyong Huang, Heqiu Zhang, Wei Kong, Youchun Wang, Immunogenicity and efficacy of a bacterially expressed HEV ORF3 peptide, assessed by experimental infection of primates. ARCHIVES OF VIROLOGY, (2009) 154:1641–1648。(1.85)
27. En-Qi Wu, En-qi Wu, Xiao Zha, Xiang-hui Yu, Guo-nan Zhang, Yong-ge Wu, Ying Fan, Yuan Ren, Ling-Qian Kong and Wei Kong, Profile of Physical Status and Gene Variation of HPV58 Genome in Cervical Cancer, Journal of General Virology, 2009 90: 1229-37 (Impact Factor (2007): 3.120.)
28. En-qi Wu, Guo-nan Zhang, Xiang-hui Yu, Yuan Ren, Ying Fan, Yongge Wu, Wei Kong and Xiao Zha, Distribution of HPV Genotypes in Archival Cervical Lesions in Eastern Inner Mongolian Autonomous Region, China., International Journal of Gynecological Cancer. 2009 Jul;19(5):919-23。Impact Factor (2007): 1.425.
29.Wenyan Zhang, Michael Huang, Tao Wang, Lindi Tan, Chunjuan Tian, Xianghui Yu, Wei Kong, Xiao-Fang Yu, Conserved and non-conserved features of HIV-1 and SIVagm Vif mediated suppression of APOBEC3 cytidine deaminases. Cell Microbiol. 2008; 10(8): 1662-75. (5.07)
30. Shuzi Zhang, Haihong Zhang, Heliang Shi, Xianghui Yu, Wei Kong*, Wei Li, Induction of immune response and anti-tumor activities in mice with a DNA vaccine encoding Human mucin 1 variable-number tandem repeats, Human Immunology, (2008)69, 250-258.(2.605)
31. Wu EQ, Zhang GN, Yu XH, Ren Y, Fan Y, Wu YG, Kong W, Zha X, Evaluation of high-risk human papillomaviruses type distribution in cervical cancer in Sichuan province of China, BMC Cancer, 2008 Jul 22;8:202 . (2.359)
32. Chong Huihui, Hong Kunxue, Zhang Chuntao, Nie Jianhui, Song Aijing, Kong Wei, Wang Youchun. Genetic and Neutralization Properties of HIV-1 ENV Clones From Subtype B/BC/AE Infections in China, J Acquir Immune Defic Syndr. 2008;47(5):535-543。 (3.946)
33. Xianfeng Zhou, Xizhen Zhang, Xianghui Yu, Xiao Zha, Qiuan Fu, Bin Liu, Xueyun Wang, Yan Chen, Yue Chen, Yaming Shan, Yinghua Jin, Yongge Wu, Junqiu Liu, Wei Kong, Jiacong Shen, the effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine, Biomatierials, 29 (2008) 111–117。 (5.196)
34. Xianfeng Zhou, Bin Liu, Xianghui Yu, Xiao Zha, Xizhen Zhang, Xueyun Wang, Yinghua Jin, Yongge Wu, Yue Chen, Yaming Shan, Yan Chen , Junqiu Liu, Wei Kong, Jiacong Shen, Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime, Eur J Pharm Biopharm, 68 (2008) 589–595。(3.185)
获奖情况: 2004年,荣获“全国归侨侨眷先进个人荣誉称号”;
2005年,被授受“国务院政府特殊津贴”;
2005年,被授予“海外华侨华人专业人士‘杰出创业奖’”;
2005年,被授予“长春市科技英才荣誉奖”;
2005年,被评为“吉林省优秀留学回国人员”;
2005年,被评为“吉林省第二届‘创业先锋’”;
2006年,被授予“长春市有突出贡献专家”;
2007年,被授予“新世纪人才”;
2009年,被授予“吉林省劳动模范称号”;
2009年,新世纪百千万人才工程国家级人选;
2012年,被授予“全国五一劳动奖章”。
社会兼职: 国家自然科学基金委员会评审专家
科技部“863”评审专家
国家食品药品监督管理局药品审评中心专家
吉林大学学位评定委员会委员
吉林大学学报(理学版)编委
吉林省科学学与科技管理研究会第五届理事会理事

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