研究成果: |
课题组通过对基因时空特异性表达和基因组稳定性的表观遗传学机制研究,解析表观遗传与人类疾病之间的关系,进而研发癌症、肌少症、心肌损伤、器官纤维化、早衰等衰老相关疾病干预策略。近年来,以基因突变(LMNA C1824T)的HGPS细胞衰老模型和化学小分子诱导肿瘤细胞衰老模型为研究对象,研究成果先后在 Cancer letter、Nature Aging、EMBO Journal等知名期刊发表学术论文14篇。其中发表在Nature Aging期刊上的文章入选Nature期刊“Research Highlights”专栏,同时美国马里兰大学Huijing Xu 等在同期Nature Aging 杂志“News & Views”专栏发表评论文章。主持国家自然科学基金青年项目1项,作为项目骨干参与国家和省部级科研项目6项,并获吉林大学优秀青年培育计划项目的支持,申请国家专利5项。
承担科研项目 1. 国家自然科学基金青年科学基金项目,项目编号:32400975,2025/01-2027/12,30万,主持,在研 2. 吉林大学优青青年培育计划项目,2024-2025,20万,主持,在研 3. 国家自然科学基金面上项目,项目编号:32271207,2023/1- 2026/12,54万,参加,在研 4. 国家自然科学基金面上项目,项目编号:32171163,2022/1- 2025/12,58万,参加,在研 5. 国家自然科学基金面上项目,项目编号:31771335,2018/1- 2021/12,61万,参加,结题 6. 吉林省科技厅重点科技研发项目,项目编号:20200404106YY, 2020/01- 2022/12,30万,参加,结题 7. 吉林省科技厅自然科学基金(学科布局项目),项目编号:20180101234JC,2018/1-2020/12,15万,参加,结题
代表性期刊论文(近五年) 1. Liu X, Zheng W, Zhang L, Cao Z, Cong X, Hu Q, Hou J, Jin X, Yuan Q, Lin L, Tan J, Lu J, Zhang Y*, Zhang N*. Arginine methylation-dependent cGAS stability promotes non-small cell lung cancer cell proliferation. Cancer Letters, 2024, 28(595):217003. (IF2023=9.1) 2. Zhang N#, Hu Q#, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J*, Li Zhan*, Zhang Y*. Unique progerin-C terminal peptide ameliorates Hutchinson-Gilford Progeria Syndrome phenotype by rescuing BUBR1. Nature Aging,2023, 3(2):185-201. (IF2023=17) 3. Hu Q#, Zhang N#, Li G, Wang Z, Huang B, Lu J*, Zhang Y*. Anti-novel-miR-59 alleviates premature senescence of Hutchinson-Gilford progeria syndrome by regulating HMGA1-mediated transcription. Embo Journal. 2023, 42(1): e110937. (IF2023=9.5) 4. Zhang N, Shang M, Li H, Wu L, Dong M, Huang B, Lu J, Zhang Y*. Dual inhibition of H3K9me2 and H3K27me3 promotes tumor cell senescence without triggering the secretion of SASP. International Journal of Molecular Sciences, 2022, 23(7): 3911. (IF2022=6.2) 5. Zhang N, Ji J#, Zhou D, Liu X, Zhang X, Liu Y, Xiang W, Wang M, Zhang L, Wang G, Huang B, Lu J, Zhang Y*. Doxorubicin induced senescence of breast cancer MCF-7 cells promotes EMT through activating Notch signaling. International Journal of Molecular Sciences, 2021, 22(2):849. (IF2021=5.9) 6. Lin C, Li H, Liu J, Hu Q, Zhang S, Zhang N, Liu L, Dai Y, Cao D, Li X, Huang B, Lu J*, Zhang Y*. Arginine hypomethylation-mediated proteasomal degradation of histone H4 — an early biomarker of cellular senescence. Cell Death and Differentiation. 2020, 27(9): 2697-2709. (IF2020=12.4) 7. Liu J, Feng J, Li L, Lin L, Ji J, Lin C, Liu L, Zhang N, Duan D, Li Z, Huang B, Zhang Y*, Lu J*. Arginine methylation-dependent LSD1 stability promotes invasion and metastasis of breast cancer. EMBO Reports, 2020, 21(2): e48597. (IF2020=8.8) 8. Liu L, Zhang X, Ding H, Liu X, Cao D, Liu Y, Liu J, Lin C,Zhang N, Wang G, Hou J, Huang B, Zhang Y*, Lu J*. Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS. Oncogene,2021, 40(20): 3548-3563. (IF2021=8.7)
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