师资队伍

生物化学与分子生物学系

王继东

日期:2020-08-11 点击数: 来源:
王继东
姓名: 王继东
职称: 副教授
最高学位: 博士
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研究方向: 主要研究领域为活性多肽与手性药物合成。在氨基酸侧链保护以及消旋抑制等方面发表论文十余篇。首创氨基酸侧链保护新方法,已被1999年第3版“Protective Groups in Organic Synthesis”(editors,Theodora W.Greene and Peter G.M.Wuts, Published by John Wiley & Sons,Inc. pp594)摘录,另有多篇文章被该书引用(pp625)。近两年在京都大学藤井信孝教授实验室从事HIV蛋白酶抑制剂的研制工作,在不对
教育经历: 1984.9-1988.6 吉林大学化学系有机化学专业 学士
1988.9-1991.6 吉林大学分子生物学系生物化学专业 硕士
1993.9-1996.6 吉林大学化学系高分子化学(生物大分子方向)博士
工作经历: 1991.7-1993.4 天津市氨基酸公司津北研究所助理工程师
1996.8 至今 吉林大学生命科学学院任职
1996.9 吉林大学生命科学学院 讲师
1998.9 吉林大学生命科学学院 副教授
1995.5-1996.11 日本神户学院大学药学院访问学者
1999.10-2001.10日本京都大学药学院 博士后
研究成果: 主要论文:
1. Development of a new N(π)-protecting group for histidine,N(π)-1-Adamantyloxymethyl histidine Yoshio Okada, Jidong Wang, Takeshi Yamamoto and Yu Mu,Chem. Pharm. Bull.44(4), 871-873 (1996).
2. Synthesis of N(π)-2-Adamantyloxymethylhistidine, His[N(π)-2-Adom]
And Its Evaluation for Peptide Synthesis
Yoshio Okada, Jidong Wang, Takeshi Yamamoto and Yu Mu,J. Chem. Soc. Perkin Trans(Ⅰ),1996(8),753-4.
3. Amino acids and peptides part 45. Development of a new N(π)-protecting Group of histidine, N(π)-1-adamantyloxymethylhistidine, and its Evaluation for peptide synthesis,Yoshio Okada, Jidong Wang, Takeshi Yamamoto and Yu Mu,J. Chem. Soc. Perkin Trans(Ⅰ), 1996(17) 213
4. Synthesis of tert-butyl esters of aspartic acid and lutamic acid via B,B-difluoroboroxazolidones Jidong Wang, Yoshio Okada, Zongmu Wang, Yuhong Wang, Wei Li, Chem. Pharm. Bull. 44(11), 2189-2191(1996).
5. 2,2-Difluoro-1,3,2-oxazaborolidin-5-ones ---a novel approach for selective side-chain otections of serine and threonine Jidong Wang, Yoshio kada, Wei Li, Toshio Yokoi, Jintao Zhu,J. Chem. Soc. Perkin Trans(Ⅰ), 1997(5) 621-624.
6. A Facile preparation of 2,2-Difluoro-1,3,2-oxazaborolidin-5-ones (I) and Their Application to Side-chain Protection of Asp, Glu, Ser and hr.
Jidong Wang, Wei Li. Peptide Science-Present and Future. 1998 Kluwer Academic Publishers, Y. Shimonishi(Ed).560-562.
7. Solvothermal Synthesis and Characterization of a New Titanium Phosphate with a One-Dimensional Chiral Chain Yanghong Guo,Zhan Shi,Jihong Yu, Jidong Wang,Yunling Liu and Wenqin Pang Chemistry of Materials, 2001, 13, 203.
8. Design and Synthesis of a Novel Peptidomimetic Inhibitor of Caspase-3,Jinliang Zhang, Linhua Liu, Yanghong Guo, Jingang Yang, Wei Li, Dafang Zhong, and Jidong Wang Chemical Research in Chinese Universities 2006, Vol.22, No.2, 225-228
9. Design,Synthesis and Molecular Docking of a Novel Small-molecule Inhibitor of Caspase-3,HANG Jin-liang; GUO Yang-hong; GAO Chao-hui;WANG En-si; REN Zhong-yuan; FANG Xue-xun and WANG Ji-dong Chemical Research in Chinese Universities 2010, Vol.26, No.2, 256-258