| 研究成果： |
承担了国家"十一五"和"十二五"重大科技专项子课题、吉林省重点科研课题和企业横向课题等10多项，发表学术论文50多篇（其中多数发表在SCI收录的学术期刊上），出版专著和教材2部。2013年，获得吉林省自然科学奖，一等奖（排名第四名）。
开展了教学改革研究，承担1项教育部教改项目。所讲授的生命科学学院本科生《生物化学》课程被评为吉林大学和吉林省精品课程，所在教学团队被评为吉林省优秀教学团队。
近五年发表的代表性论文：
1. Hualong Xi, Kaixin Zhang, Yanchun Yin, Tiejun Gu, Qing Sun, Linqing Shi, Renxia Zhang,Chunlai Jiang, Wei Kong, Yongge Wu*. Fusion Peptide Improves Stability and Bioactivity of Single Chain Antibody against Rabies Virus. J. Microbiol. Biotechnol. 2017, 27(4):718-724.
2. Hualong Xi, Kaixin Zhang, Yanchun Yin, Tiejun Gu, Qing Sun, Zhuang Li, Yue Cheng, Chunlai Jiang, Wei Kong, Yongge Wu*. Engineering of a novel zipFv using leucine zipper motif against rabies virus glycoprotein G with improved protection potency in vivo. Immunology Letters, 2017,186 (4):9-14.
3. Jingcai Lu, Hongjia Hou, Dandan Wang, Kees Leenhouts, Maarten L.van Roosmalen,Tianxu Sun, Tiejun Gu, Yueshuang Song, Chunlai Jiang, Wei Kong, Yongge Wu* . Systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant Plym2. Immunology Letters, 2017,187 (5):41-46.
4. Zhuang Li, Yue Cheng, Hualong Xi, Tiejun Gu, Ruosen Yuan, Xiaoxu Chen, Chunlai Jiang, Wei Kong?, Yongge Wu?. A novel variable antibody fragment dimerized by leucine zippers with enhanced neutralizing potency against rabies virus G protein compared to its corresponding single-chain variable antibody fragment. Molecular Immunology, 2015,68 (2) :168-175.
5. Ruosen Yuan，Xiaoxu Chen，Yan Chen，Tiejun Gu，Hualong Xi，Ye Duan ，Bo Sun，Xianghui Yu，Chunlai Jiang，Xintao Liu，Chunlai Wu，Wei Kong，Yongge Wu*. Preparation and diagnostic use of a novel recombinant single-chain antibody against rabies virus glycoprotein. Appl Microbiol Biotechnol. 2014 Feb;98(4):1547-55.
6. Duan Y, Gu T, Zhang X, Jiang C, Yuan R, Li Z, Wang D, Chen X, Wu C, Chen Y, Wu Y*, Kong W*. Negative effects of a disulfide bond mismatch in anti-rabies G protein single-chain antibody variable fragment FV57. Molecular Immunology, 2014 Mar 2;59(2):136-141
|
