姓名：杨胜彩
职称：副教授
最高学位：理学博士学位
邮箱：yang_shengcai@jlu.edu.cn
电话：18744015976
工作地点：生命科学楼239室
研究方向：医用酶分子设计、组装与递送研究；肿瘤与炎症基因治疗研究
教育经历：
2010.09-2014.07吉林大学化学学院化学学士
2014.09-2019.07吉林大学化学学院高分子化学与物理博士
2014.09-2019.07中国科学院长春应用化学研究所高分子化学与物理博士（联合培养）
工作经历：
2019.09-2022.03新加坡科技研究局博士后
2022.06—至今 吉林大学分子酶学工程教育部重点实验室副教授
荣誉奖励：
2022年，入选吉林大学“唐敖庆青年学者”支持
2024年，获得吉林大学“励新优秀青年教师培养计划”支持
获得项目情况：
1.不同功能基团的电中性Drug-Free纳米颗粒的构建及克服肿瘤耐药的研究，主持，国家自然科学基金青年基金项目，30万2023.01-2025.12
2.治疗性聚氨基酸材料及纳米颗粒克服肿瘤耐药的机制探究，主持，吉林省自然科学基金（省地合作基金-长春创新发展联合基金），15万2024.01-2026.12
3.聚酯载体介导迷你型基因编辑工具IscB-ωRNA用于动脉粥样硬化治疗,主持，吉林省科技厅国际科技合作项目，10万 2025.01-2027.12
4.吉林省企业“科创专员”（科创副总），2024.01-2025.12
5.治疗性聚氨基酸材料及纳米颗粒克服肿瘤耐药的机制探究，主持，吉林大学青年师生交叉学科培育项目，2万2023.09-2025.8
代表性研究成果：
1.Shengcai Yang, Zhaohui Tang*, Chenyang Hu, Dawei Zhang, Na Shen, Haiyang Yu, Xuesi Chen*. “Selectively potentiating hypoxia levels by combretastatin A4 nanomedicine: Towards highly enhanced hypoxia-activated prodrug tirapazamine therapy for metastatic tumors”Adv. Mater.,2019, 31, 1805955.
2.Jiaxin Yin,Shengcai Yang*, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu*, and Quanshun Li*.“Regulating Tumor Metabolic Reprogramming with Biomimetic Co-Delivery of Simvastatin and Kynureninase for Immunotherapy”Adv. Sci., 2025, 13，e08107.
3.Zengguang Liu, Jiaxin Yin, Tianyuan Qiu, Aijiang Liu, Yanan Yu,Shengcai Yang*, Ziling Liu*, Quanshun Li*, “Reversing the immunosuppressive tumor microenvironment via “Kynurenine starvation therapy” for postsurgical triple-negative breast cancer treatment”.J. Control. Release, 2025, 383, 113832.
4.Shengcai Yang, Jiayu Leong, Yanming Wang, Rachel Sim, Ko Hui Tan, Yau Hong Chua, Nathanael Tan, Ashlynn LZ Lee, Joyce Tay, Yi Yan Yang*. “Drug-free neutrally charged polypeptide nanoparticles as anticancer agents”J. Control. Release, 2022, 345, 464-474.
5.Xinxin Shao#, Xinxin Feng#, Jinran Feng, Tianyuan Qiu,Shengcai Yang*, Quanshun Li* “Exosome-mediated co-delivery of superoxide dismutase and chondroitinase ABC for multiple sclerosis therapy”.Int. J. Biol. Macromol., 2025, 327, 147438
6.Shengcai Yang, Yanming Wang, Jason Tan, Jye Yng Teo, Ko Hui Tan, Yi Yan Yang*. “Antimicrobial polypeptides capable of membrane translocation for treatment of MRSA wound infection in vivo”Adv. Healthc. Mater.2022, 11 (6), 2101770.
7.Xiao Liang, Kai Wen, Yingxuan Chen, Guangxu Fang,Shengcai Yang*, Quanshun Li*.“Oral administration of therapeutic enzyme capsule for the treatment of inflammatory bowel disease”Int. J. Nanomedicine, 2022, 17, 4843.
8.Xinxin Shao,Mengzhu Zhang, Yingxuan Chen, Siyu Sun,Shengcai Yang*,Quanshun Li*. “Exosome-mediated delivery of superoxide dismutase for anti-aging studies inCaenorhabditis elegans”Int. J. Pharmaceutics, 2023, 641, 123090.
9.Mengzhu Zhang, Siyu Sun, Xiao Liang, Zengguang Liu, Jiaxin Yin, Quanshun Li,* andShengcai Yang*“Quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy”Biomater. Sci.,2024,12, 1197-1210
