姓名:杨胜彩
职称:副教授
最高学位:博士
邮箱:yang_shengcai@jlu.edu.cn
电话:18744015976
工作地点:生命科学楼239室
研究方向:酶分子组装与递送研究、肿瘤与炎症基因治疗研究
教育经历:
2010.09-2014.07 吉林大学化学学院 化学 学士
2014.09-2019.07 吉林大学化学学院 高分子化学与物理 博士
2014.09-2019.07 中国科学院长春应用化学研究所 高分子化学与物理 博士(联合培养)
工作经历:
2019.09-2022.03 新加坡生物工程与生物影像研究所,新加坡科技研究局 博士后
2022.06—至今 吉林大学分子酶学工程教育部重点实验室 副教授
荣誉奖励:
2022年,入选吉林大学“唐敖庆青年学者“支持
获得项目情况:
1. 不同功能基团的电中性Drug-Free纳米颗粒的构建及克服肿瘤耐药的研究,主持,国家自然科学基金青年基金项目,30万 2023.01-2025.12
2. 治疗性聚氨基酸材料及纳米颗粒克服肿瘤耐药的机制探究,主持,吉林省自然科学基金(省地合作基金-长春创新发展联合基金),15万 2024.01-2026.12
3. 吉林省企业“科创专员”(科创副总),2024.01-2025.12
4. 治疗性聚氨基酸材料及纳米颗粒克服肿瘤耐药的机制探究,主持,吉林大学青年师生交叉学科培育项目,2万 2023.09-2025.8
研究成果:
1. Shengcai Yang, Zhaohui Tang*, Chenyang Hu, Dawei Zhang, Na Shen, Haiyang Yu, Xuesi Chen*. “Selectively potentiating hypoxia levels by combretastatin A4 nanomedicine: Towards highly enhanced hypoxia-activated prodrug tirapazamine therapy for metastatic tumors” Adv. Mater., 2019, 31, 1805955.
2. Shengcai Yang, Jiayu Leong, Yanming Wang, Rachel Sim, Ko Hui Tan, Yau Hong Chua, Nathanael Tan, Ashlynn LZ Lee, Joyce Tay, Yi Yan Yang*. “Drug-free neutrally charged polypeptide nanoparticles as anticancer agents” J. Control. Release, 2022, 345, 464-474.
3. Shengcai Yang, Yanming Wang, Jason Tan, Jye Yng Teo, Ko Hui Tan, Yi Yan Yang*. “Antimicrobial polypeptides capable of membrane translocation for treatment of MRSA wound infection in vivo” Adv. Healthc. Mater. 2022, 11 (6), 2101770.
4. Shengcai Yang, Zhaohui Tang*, Dawei Zhang, Mingxiao Deng, Xuesi Chen. “pH and redox dual-sensitive polysaccharide nanoparticles for the efficient delivery of doxorubicin” Biomater. Sci., 2017, 5, 2169-2178.
5. Shengcai Yang, Dawei Zhang, Na Shen, Guanyi Wang, Zhaohui Tang*, Xuesi Chen. “Dihydroartemisinin increases gemcitabine therapeutic efficacy in ovarian cancer by inducing reactive oxygen species” J. Cell. Biochem., 2019, 120, 634-644.
6. Xiao Liang, Kai Wen, Yingxuan Chen, Guangxu Fang, Shengcai Yang*, Quanshun Li*. “Oral administration of therapeutic enzyme capsule for the treatment of inflammatory bowel disease” Int. J. Nanomedicine, 2022, 17, 4843.
7. Xinxin Shao, Mengzhu Zhang, Yingxuan Chen, Siyu Sun, Shengcai Yang*, Quanshun Li*. “Exosome-mediated delivery of superoxide dismutase for anti-aging studies in Caenorhabditis elegans” Int. J. Pharmaceutics, 2023, 641, 123090.
8. Mengzhu Zhang, Siyu Sun, Xiao Liang, Zengguang Liu, Jiaxin Yin, Quanshun Li,* and Shengcai Yang* “Quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy” Biomater. Sci., 2024,12, 1197-1210