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科研项目: 1. 题目：酶促聚合构建生物医用高分子材料研究 国家自然科学基金区域创新发展联合基金 起止时间：2025.1.1-2028.12.31 U24A20365 2. 题目：基于金簇构建双功能模拟酶实时快速检测甲基对硫磷的研究 吉林省科技厅重点研发 社会发展领域（产业关键技术） 起止时间：2025.1.1-2027.12.31 20250203094SF 3. 题目：基于 CRISPR/Cas12 的重金属离子快速检测试剂盒研发 吉林省发改委产业技术研究与开发专项项目 起止时间：2023.1.1-2024.12.31 2023C043-5 4. 题目：基于肿瘤微环境设计构建抗癌肽的靶向缓释体系 吉林省自然科学基金 起止时间：2018.1.1-2020.12.31 20180101250JC 5. 题目：pH敏感型抗癌肽靶向缓释体系的构建与评估 吉林省教育厅“十三五”科学技术项目 起止时间：2018.1.1-2019.12.31 JJKH20180178KJ， 6. 题目：PL-AC的活性筛选及作用机理研究 江苏普莱医药生物技术有限公司 起止时间：2018.7.1-2022.6.30 2018220101001937 7. 题目：抗癌肽-阿霉素共组装靶向缓释微球的抗癌作用研究 国家自然科学基金 21442001 起至时间：2015.1-2015.12 21442001 论文专利： [1] Fengjie Hao, Jntao Hu, Ziyu Kuai, Jiachun Wang, Yuran Deng, Yu Qin, Yibing Huang*, Quan Luo*, Reprogramming Cascade Catalysis via Protein-Directed Interfacial Assembly of Spatially Ordered Clusterzymes for Enhanced Antioxidant Treatment. ACS Appl. Mater. Interfaces 2026, 10.1021/acsami.6c02411. [2] Qi Shen, Mengzhu Tong, Lu Cheng, Junxi Li, Yuze Gao, Yibing Huang*, Quan Luo *.Self-calibrating dual-signal cascade amplification strategy for anti-interference detection of carbamate pesticides via fluorescent gold nanozymes.Colloids and Surfaces A: Physicochemical and Engineering Aspects.2026,731:138994. [3] Wantong Jiang, Juntao Hu, Jiachun Wang, Ziyu Kuai , Dongwei Zhu, Yu Qin, Mengmeng Niu, Yibing Huang*, Quan Luo ,*Bifunctional gold clusterzymes with surface-engineered catalytic triad design for selective dual-signal detection of p-nitrophenyl organophosphates for food safety. Microchemical Journal, 2025,218: 115601. [4] Jiachun Wang, Juntao Hu, Wantong Jiang, Dongwei Zhu, Yinuo Yin, Yu Qin, Ao Song, Yibing Huang *, Quan Luo,*Mechanistic insights into redox-protonation coupled fluorescence switching in peptide-mediated gold nanoclusters for precision tumor imaging and resection. Journal of Colloid and Interface Science 2025, 700: 138582. [5] Juntao Hu , Yibing Huang, Hao Hao, Pujing Tian , Yinuo Yin , Yuting He, Fengjie Hao, Wantong Jiang , Yanping Zhang, Youzhong Wan,*, Quan Luo,*Bioinspired programmed antibiofilm strategies for accelerated wound healing via spatiotemporally controlled enzyme nanoreactors. Journal of Controlled Release 2025, 381:113582 [6] Ziyu Kuai, Yibing Huang, Fengjie Hao, Wantong Jiang, Mengmeng Niu, Yu qin, Ao Song, Yuran Deng,Youzhong Wan,* and Quan Luo* Atomic-Level Engineering of Protein-Templated Gold Clusterzymes with Tunable Fluorescence and Multi-Enzyme Activities for Antiaging Treatment. ACS Appl. Mater. Interfaces 2025, 17: 55199−55212. [7] Jiachun Wang, Yibing Huang, Ziyu Kuai, Yanping Zhang, Qi Shen, Pujing Tian, Weihai Nong, Wantong Jiang, Yuting He, Nana Ran, Yinuo Yin, Tiezhu Li, Quan Luo,*Ultrasensitive and rapid detection of organophosphates using a dual-signal naked-eye hydrogel sensor based on acetylcholinesterase inhibition.International Journal of Biological Macromolecules 2024,283:137778. [8] Ge Li, Yibing Huang, Linlu Zhao, Bo Yang, Jiale Guo, Juntao Hu, Jinli Wang, Hui Wang, Bin Liu, Aiguo Zhang, Fengying Sun,* and Quan Luo*.Targeting and Microenvironment-Activated Nanoreactor for Diabetic Chronic Wound Healing via Multienzyme Cascade Reactions. ACS Appl. Mater. Interfaces 2024, 16, 6315−6326. [9] Yibing Liu, Xue Jiang, Wei Wang, Wei Zhang, Pinyi Ma*, Yibing Huang,*,Daqian Song,* Single-trigger dual-modal nanoplatform for in situ switch on cancer diagnosis imaging, Sensors & Actuators: B. Chemical,2023, 381:133420 [10] Yibing Liu , Yu Zhang, Xianlong Zhang, Wei Zhang, Xinghua Wang, Ying Sun, Pinyi Ma,*, Yibing Huang,*, Daqian Song*. Near-infrared fluorescent probe based on Ag&Mn:ZnInS QDs for tyrosinaseactivity detection and inhibitor screening，Sensors & Actuators: B. Chemical 2021，344 :130234. [11] Yibing Liu, Xu He, Pinyi Ma,∗, Yibing Huang*, Xiaolei Li, Ying Sun, Xinghua Wang,Daqian Song*. Fluorometric detection of dopamine based on 3-aminophenylboronic acidfunctionalized gInZnS QDs and cells imaging. Talanta, 2020, 217:121081. [12] Yibing Liu, Fangmei Zhang, Xu He, Pinyi Ma,⁎, Yibing Huang,⁎, Shuo Tao, Ying Sun, Xinghua Wang, Daqian Song,⁎ A novel and simple fluorescent sensor based on AgInZnS QDs for the detection of protamine and trypsin and imaging of cells. Sensors & Actuators: B. Chemical . 2019, 294 : 263–269 [13] Hu C, Ma N, Li F, Fang Y, Liu Y, Zhao L, Qiao S, Li X, Jiang X, Li T, Shen F, Huang Y*, Luo Q*, Liu J. Cucurbit[8]uril-Based Giant Supramolecular Vesicles: Highly Stable, Versatile Carriers for Photoresponsive and Targeted Drug Delivery. ACS Appl Mater Interfaces. 2018,10(5):4603-4613. [14] 黄宜兵，罗全，杨龙宇。一种以多肽为配体的金纳米簇及甲基对硫磷的检测方法ZL202410688341.6 [15] 黄宜兵、姜雪、杨龙宇。一种以多肽为配体的金纳米簇及盐酸金霉素的检测方法ZL 2022 11715289.6 科技奖励： 1. 2025.11 吉林省自然科学奖二等奖 第四完成人 2. 2017.11 吉林省自然科学奖二等奖 第二完成人 3. 2014.11 吉林省自然科学学术成果奖 第二完成人 4. 2012.11 吉林省科技进步奖三等奖 第二完成人 欢迎关注“仿酶课题组”公众号 
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