研究成果 |
主持科研项目: 1.国家自然科学基金青年项目，81802909，Trim21泛素化Snail调控乳腺癌细胞EMT的表观遗传机制，2019.01-2021.12，21万，结题，主持 2.博士后创新人才支持计划，BX201600065，LSD1调控乳腺癌发生发展的机制，2016.09-2018.09，20万，已结题，主持 3.第61批中国博士后科学基金面上资助项目，2017M611315，LSD1协同EZH2调控乳腺癌细胞组蛋白甲基化的机制研究 ，2017.09-2019.09，5万，已结题，主持 4.吉林省科技发展计划，20190103069JH，Trim21泛素化Snail调控乳腺癌细胞EMT的表观遗传机制，2019.1.1~2020.12.31，7万，已结题，主持。 5. 吉林省科技发展计划，20210402018GH，UBR5泛素化Snail调控结直肠癌细胞EMT的分子机制，2021.1.1~2023.12.31，10万，已结题，主持。 6. 吉林省科技发展计划，20220101276JC，E3泛素连接酶FBXO11泛素化ZEB1调控肺癌细胞侵袭转移的研究，2022.1.1~2024.12.31，10万，在研，主持。 代表性论文： 1. Xinyue Zhao, Ruiying Liu, Zhihui Han, Zehao Li, Ling Mei,Yuyang Liu, Xueqi Fu, Yue Jin*. UBR5 regulates the progression of colorectal cancer cells through Snail-induced Epithelial–Mesenchymal Transition. Genes & Diseases.2025, doi: 10.1016/j.gendis.2025.101679. 2. Xinyue Zhao#, Jian Xiu#, Hengzheng Yang, Weiwei Han*, Yue Jin*. Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer. Int J Mol Sci. 2025 Jan 23;26(3):930. 3. Fuyan Cao#, Xinyue Zhao#, Xueqi Fu, Yue Jin*. Computational insights into exploring the potential effects of environmental contaminants on human health. Scientific Reports. 2025, 15(1):11779. 4. Xinyue Zhao, Zhihui Han, Ruiying Liu, Zehao Li, Ling Mei, Yue Jin*. FBXO11 Mediates Ubiquitination of ZEB1 and Modulates Epithelial-to-Mesenchymal Transition in Lung Cancer Cells. Cancers.2024 Sep 26;16(19):3269. 5. Jin Y, Zhao X, Zhang Q, Zhang Y, Fu X, Hu X, Wan Y. Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells. Int J Biol Macromol. 2020 Jan 1;142:782-789. 6. Jin Y, Zhang Y, Li B, Zhang J, Dong Z, Hu X, Wan Y. TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells.Int J Biol Macromol. 2019, 124:846-853. 7.Jin Y#, Huo B#, Fu X, Hao T, Zhang Y, Guo Y, Hu X. LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes. Biomed Pharmacother. 2017 Apr;88:728-737. 8. Jin Y#, Huo B#, Fu X, Cheng Z, Zhu J, Zhang Y, Hao T, Hu X. LSD1 knockdown reveals novel histone lysine methylation in human breast cancer MCF-7 cells. Biomed Pharmacother. 2017 Aug;92:896-904. 9. Jin Y#, Cai Q#, Shenoy AK, Lim S, Zhang Y, Charles S, Tarrash M, Fu X, Kamarajugadda S, Trevino JG, Tan M, Lu J.Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation. Oncotarget. 2016 May 3;7(18):25113-24. 10. Jin Y, Shenoy AK, Doernberg S, Chen H, Luo H, Shen H, Lin T, Tarrash M, Cai Q, Hu X, Fiske R, Chen T, Wu L, Mohammed KA, Rottiers V, Lee SS, Lu J. FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Cancer Lett. 2015 Jun28; 362(1):70-82. |
