研究成果 |
主持科研项目： 1. Trim21泛素化Snail调控乳腺癌细胞EMT的表观遗传机制（81802909），国家自然科学基金青年项目，2019.01-2021.12，项目负责人。 2. LSD1调控乳腺癌发生发展的机制（BX201600065），博士后创新人才支持计划，2016.09-2018.09，项目负责人。 3. LSD1协同EZH2调控乳腺癌细胞组蛋白甲基化的机制研究（2017M611315），第61批中国博士后科学基金面上资助项目，2017.09-2019.09，项目负责人。 4. Trim21泛素化Snail调控乳腺癌细胞EMT的表观遗传机制（20190103069JH），吉林省科技发展计划优秀青年人才基金项目，项目负责人。 代表性期刊论文： 1.Jin Y, Shenoy AK, Doernberg S, Chen H, Luo H, Shen H, Lin T, Tarrash M, Cai Q, Hu X, Fiske R, Chen T, Wu L, Mohammed KA, Rottiers V, Lee SS, Lu J.FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.Cancer Lett. 2015; 362(1):70-82. 2. Jin Y#, Cai Q#, Shenoy AK,Lim S,Zhang Y,Charles S,Tarrash M,Fu X,Kamarajugadda S,Trevino JG,Tan M,Lu J.Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation. Oncotarget. 2016; 7(18): 25113- 24. 3. Jin Y, Zhao X, Zhang Q, Zhang Y, Fu X, Hu X, Wan Y. Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells. Int J Biol Macromol. 2020; 142:782-789. 4. Jin Y, Zhang Y, Li B, Zhang J, Dong Z, Hu X, Wan Y. TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells.Int J Biol Macromol. 2019; 124:846-853. 5.Jin Y#,Huo B#,Fu X,Hao T,Zhang Y,Guo Y,Hu X. LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes.Biomed Pharmacother. 2017; 88:728-737. 6.href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Jin%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=28601046" Jin Y#,Huo B#,Fu X,Cheng Z,Zhu J,Zhang Y,Hao T,Hu X. LSD1 knockdown reveals novel histone lysine methylation in human breast cancer MCF-7 cells.Biomed Pharmacother. 2017; 92:896-904. 7.Shenoy AK,Jin Y,Luo H,Tang M,Pampo C,Shao R,Siemann DW,Wu L,Heldermon CD,Law BK,Chang LJ,Lu J. Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells. J Clin Invest. 2016; 126(11):4174-4186. 8 Chen H, Fang X, Jin Y, Hu X, Yin M, Men X, Chen N, Fan C, Chiu DT, Wan Y, Wu C. Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host- Guest Interactions, and Enhanced Drug/siRNA Delivery. Small. 2018;14(21): e18002 39. 9. Hu X,Xiang D, Xie Y, Tao L, Zhang Y,Jin Y, Pinello L, Wan Y, Yuan G, Li Z.LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression. Oncogene. 2019; 38(44):7017-7034. 10.Luo H,Shenoy AK,Li X,Jin Y,Jin L,Cai Q,Tang M,Liu Y,Chen H,Reisman D,Wu L,Seto E,Qiu Y,Dou Y,Casero RA Jr,Lu J. MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial to Mesenchymal Transition. Cell Rep. 2016;15(12):2665-78. 11. Wang Z, Xu D, Wang X, Jin Y, Huo B, Wang Y, He C, Fu X, Lu N . Size- matching hierarchical micropillar arrays for detecting circulating tumor cells in breast cancer patients' whole blood. Nanoscale. 2019; 11(14):6677-6684. 12 Kamarajugadda S, Cai Q, Chen H, Nayak S, Zhu J, He M,Jin Y, Zhang Y, Ai L, Martin SS, Tan M, Lu J.Manganese superoxide dismutase promotes anoikis resista-nce and tumor metastasis. Cell Death Dis. 2013; 4:e504. 13.Tang M#, Shen H#,Jin Y, Lin T, Cai Q, Pinard MA, Biswas S, Tran Q, Li G, Shenoy AK, Tongdee E, Lin S, Gu Y, Law BK, Zhou L, McKenna R, Wu L, Lu J.The Malignant Brain Tumor (MBT) Domain Protein SFMBT1 Is an Integral Histone Reader Subunit of the LSD1 Demethylase Complex for Chromatin Association and Epithelial-to-mesenchymal Transition.J Biol Chem. 2013; 288(38):27680-91. 14.Guo Y,Fu X, Jin Y, Sun J,Liu Y,Huo B,Li X,Hu X.Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation. Drug Des DevelTher. 2015; 9:3153-62. 15．Zhang Y, Wan Y, Huo B, Li B, Jin Y, Hu X. Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells.Onco Targets Ther. 2018; 11:4377-4386. |
