研究成果： |
杨照罡博士迄今共发表SCI论文130余篇，其中以第一或通讯作者身份发表60余篇，代表性论文多次发表在Nature Biomedical Engineering，Nature Nanotechnology, Nature Communications等高水平期刊。其论文总影响因子超过800，累计被引8000余次，h指数为51，连续多年入选全球前2%顶尖科学家年度影响力榜单。先后主持或参加包括美国NIH R21、国家自然科学基金优秀青年（海外）、国家自然科学基金面上项目在内的课题10余项；已授权及申请中美专利共8项。以章节负责人或章节主要参与人撰写英文著作8篇。目前兼任中国抗癌协会专业委员会委员，并担任Asian Journal of Pharmaceutical Sciences 等期刊青年编委。此外，担任 Nature Communications, Advanced Functional Materials, Journal of Controlled Release, ACS Nano等几十个期刊审稿人；以客座编辑身份在Frontiers in Pharmacology，Molecules，Frontiers in Immunology等多个SCI杂志组织发表特刊。 代表性论文： 1. S. Wang, J. Chen, Y. Cui, J. Xing, J. Liu, H. Jiang, H. Yang, H. Zhang, M. Sun, J. Li, W. Liu, Z. Chen, W. Sun*, X. Wang*, Z. Yang*. Multifunctional extracellular vesicles inhibiting autophagy ameliorate immune tolerance in non-small cell lung cancer. Acta Pharmaceutica Sinica B, 2026, 16(2):1022-45（*通讯，影响因子14.6） 2. H. Zhang, J. Xing, M. Sun, Y. Cui, Y. Li, S. Hu, X. Wang, H. Jiang, Y. Zhang, X. Jiang, F. Yang, B. Kim, W. Jiang, Z. Yang*, L. Teng*. Engineered exosomes for targeted microRNA delivery to reverse liver fibrosis. Biomaterials, 2026, 324:123510（*通讯，影响因子12.9） 3. H. Zhang, M. Sun, J. Chen, S. Wang, J. Liu, H. Yang, L. Liu, S. Hu, F. Yang, L. Teng, Z. Chen, X. Wang, S. Dong, Y. Ma, J. Edwards, X. Wang, Y. Chang, B. Kim, W. Jiang*, Y. Cui*, Z. Yang*. Immunological conversion of triple-negative breast cancer by engineered extracellular vesicle-mediated pyroptosis. Journal of Controlled Release, 2026, 389:114493（*通讯，影响因子11.5） 4. W. Bao, X. Qu, Y. Wang, D. Huang, H. Zhang, M. Dong, H. Sun, Z. Yang*, X. Li*. Targeted Therapy for Tumor-Associated Macrophages: From Interaction Networks to Clinical Translation. MedComm, 2026, 7(2):e70599（*通讯，影响因子10.7） 5. K. Tang, Z. Tang, M. Niu, Z. Kuang, W. Xue, X. Wang, X. Liu, Y. Yu, S. Jeong, Y. Ma, A. Wu, B. Kim, W. Jiang*, Z. Yang*, C. Li*. Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions, Nature Communications, 2025,16:3410（*通讯，影响因子15.7） 6. M. Sun, H. Zhang, Y. Ma, S. Wang, J. Chen, Y. Cui, Y. Zhang, S. Hu, D. Zhou, P. Zhang, Y. Liu, B. Kim, W. Jiang, X. Wang*, Z. Yang*. In situ programming of the tumor microenvironment to alleviate immunosuppression for pancreatic cancer immunotherapy, Advanced Science, 2025, e04008（*通讯，影响因子14.1） 7. S. Wang, J. Liu, Y. Cui, M. Sun, W. Wang, J. Chen*, J. Gu*, Z. Yang*. Macrophage-centered therapy strategies: a promising weapon in cancer immunotherapy. Asian Journal of Pharmaceutical Sciences, 2025, 101063（*通讯，影响因子11.9） 8. F. Gao, X. Liu, Z. Ma, M. Tang, Z. Tang, J. Wu, M. Luo, Y. Tang, X. Wang, B. Wang, B. Kim, Z. Yang*, W. Jiang*, P. Tang*, C. Li*. An integrated modular vaccination system for spatiotemporally separated perioperative cancer immunotherapy. Advanced Materials, 2025, e2418322（*通讯，影响因子26.8） 9. J. Chen, S. Hu, J. Liu, H. Jiang, S. Wang*, Z. Yang*. Exosomes: a double-edged sword in cancer immunotherapy. MedComm, 2025, 6(3): e70095（*通讯，影响因子10.7） 10. X. Bian, L. Yang, D. Jiang, A. Grippin, Y. Ma, S. Wu, L. Wu, X. Wang, Z. Tang, K. Tang, W. Pa, S. Dong, B. Kim, W. Jiang*, Z. Yang*, C. Li*. Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles. Nature Communications, 2024, 15(1):3987.（*通讯，影响因子14.7） 11. H. Zhang, A. Grippin, M. Sun, Y. Ma, B. YS Kim, L. Teng, W. Jiang*, Z. Yang*. New avenues for cancer immunotherapy: Cell-mediated drug delivery systems. Journal of Controlled Release, 2024, 375: 712-32. （*通讯，影响因子10.5） 12. S. Dong, X. Liu, Y. Bi, Y. Wang, A. Antony, D. Lee, K. Huntoon, S. Jeong, Y. Ma, X. Li, W. Deng, B. Schrank, A. Grippin, J. Ha, M. Kang, M. Chang, Y. Zhao, R. Sun, X. Sun, J. Yang, J. Chen, S. Tang, L. Lee, A. Lee, L. Teng, S. Wang*, L. Teng*, B. Kim*, Z. Yang*, W. Jiang*. Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer. Nature Communications, 2023, 14(1):6610.（*通讯，影响因子16.6） 13. Y. You#, Y. Tian#, Z. Yang#, J. Shi, K. Kwak, Y. Tong, A. Estania, J. Cao, W. Hsu, Y. Liu, C. Chiang, B. Schrank, K. Huntoon, D. Lee, Z. Li, Y. Zhao, H. Zhang, T. Gallup, J. Ha, S. Dong, X. Li, Y. Wang, W. Lu, E. Bahrani, L. Lee, L. Teng, W. Jiang, F. Lan, B. Kim, A. Lee. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nature Biomedical Engineering, 2023, 7(7):887-900.（ESI高被引,影响因子28.1） 14. Q. Zhu, Y. Zhang, M. Li, Y. Zhang, H. Zhang, J. Chen, Z. Liu, P. Yuan, Z. Yang*, X. Wang*. MiR-124-3p impedes the metastasis of non-small cell lung cancer via extracellular exosome transport and intracellular PI3K/AKT signaling. Biomarker Research, 2023, 11(1):1（*通讯，影响因子11.1） 15. S. Dong, Y. Bi, X. Sun, Y. Zhao, R. Sun, Y. Sun, Y. Wang, Z. Yang*, W. Jiang*, L. Teng*. Dual-loaded liposomes tagged with hyaluronic acid have synergistic effects in triple negative breast cancer. Small, 2022, e2107690.（*通讯，影响因子13.3） 16. Z. Huang#, B. Tang#, Y. Yang#, Z. Yang#, L. Shi, Y. Bai, B. Yan, R. Karnes, J. Zhang, R. Jimenez, L. Wang, Q. Wei, J. Yang, W. Xu, Z. Jia, H. Huang. MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression. Cancer Research, 2021, 81(17):4471-4484.（影响因子11.2） 17. Z. Yang#, J. Shi#, J. Xie, Y. Wang, J. Sun, T. Liu, Y. Zhao, X. Zhao, X. Wang, Y. Ma, V. Malkoc, C. Chiang, W. Deng, Y. Chen, Y. Fu, K. Kwak, Y. Fan, C. Kang, C. Yin, J. Rhee, P. Bertani, J. Otero, W. Lu, J. Yun, A. Lee, W. Jiang, L. Teng, B. Kim, L. Lee, Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation, Nature Biomedical Engineering, 2020, 4(1), 69-83.（封面论文，ESI高被引,影响因子28.1） https://scholar.google.com/citations?user=3IxTX7UAAAAJ&hl=en 本课题组长期招聘博士后，欢迎优秀学者加入！ |
