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生物工程系

高仁钧

日期:2020-08-11 点击数: 来源:


高仁钧


姓名: 高仁钧











































































































































































































































职称: 教授











































































































































































































































最高学位: 博士











































































































































































































































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工作地点: 生命科学楼233




































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































研究方向: 研究方向: 1) 新酶筛选,特别是嗜热微生物来源的嗜热酶的筛选。 2) 基于蛋白质工程的酶的分子改造与固定化。 3) 酶的调控、表达、工程化制备和酶催化应用。
教育经历: 1992.09-1996.07 吉林大学分子生物学系分子生物学专业, 获学士学位
1998.09-2003.12 吉林大学生命科学学院,获博士学位
2005.09-2007.08 中科院长春应用化学研究所和海王生物 博士后
工作经历: 2000.04-2000.07 日本工业技术院生命工学研究所,访问学者
2001.09-2002.08 吉林大学分子酶学工程教育部重点实验室,助教
2002.09-2004.08 吉林大学分子酶学工程教育部重点实验室,讲师
2004.09-2009.08 吉林大学生命科学学院分子酶学工程教育部重点实验室,副教授
2009.09-现在 吉林大学生命科学学院分子酶学工程教育部重点实验室,教授, 博士生导师
2010.09-2011.09 丹麦奥胡斯大学分子生物学系,访问学者
2018.01-2018.01丹麦奥胡斯大学分子生物学系,访问学者
荣誉称号: 中国生物化学与分子生物学学会工业生物化学分会常务理事
吉林省生物化学与分子生物学会 理事
吉林大学生命科学学院学术委员会 委员
吉林大学生命科学学院学位委员会 委员
吉林大学生命科学学院教学委员会 委员
研究成果: 正在执行的项目:
国家自然科学基金:嗜热酰基氨肽酶非特异性催化机制的研究及改造
吉林省自然科学基金:高温糖基化生物反应器的构建

国家重点研发计划项目子课题: 基于酶和工程菌改造技术的分布式DNA活字存储阵列研究 


发表文章:

[1] Li Zong, Yan Zhang, Zhengkang Shao, Yingwu Wang, Zheng Guo, Renjun Gao*, Bekir Engin Eser*, Optimization and Engineering of a Self-Sufficient CYP102 Enzyme from Bacillus amyloliquefaciens towards Synthesis of In-Chain Hydroxy Fatty Acids, Catalysts 2021, 11(6), 665.

[2] Li Zong, Renjun Gao, Zheng Guo, hengkang Shao, Yingwu Wang*, Bekir EnginEser*, Characterization and modification of two self-sufficient CYP102 family enzymes from Bacillus amyloliquefaciens DSM 7 with distinct regioselectivity towards fatty acid hydroxylation, Biochemical Engineering Journal, 2021, 166, 107871.

[3] Jiabao Lyu, Renjun Gao, and Zheng Guo*, Galactosyldiacylglycerols: From a Photosynthesis-Associated Apparatus to Structure-Defined In Vitro Assembling, Publication Date: April 1, 2021, https://doi.org/10.1021/acs.jafc.1c00204.

[4] Fang Wang, Rong Li, Hui Jian, Zihao Huang, Yingwu Wang*, Zheng Guo*, and Renjun Gao*, Design and construction of an effective expression system with aldehyde tag for site-specific enzyme immobilization,Catalysts, 2020, 10(4), 410.
[5] Dongni Liu, Lin Deng, Dan Wang, Wei Li, Renjun Gao*,“Bridge regions” regulate catalysis and protein stability of acylpeptide hydrolase, Biochemical Engineering Journal, 2019, 145, 42-52.
[6] Wei Li, Dongni Liu, Xu Geng, Zhengqiang Li* and Renjun Gao*, Real-time regulation of catalysis by remotecontrolled enzyme-conjugated gold nanorod composites for aldol reaction-based applications, Catalysis Science & Technology, 2019, 2221-2230.
[7] Ye Zhou, Bianca Pérez, Weiwei Hao, Jiabao Lv, Renjun Gao*, Zheng Guo*, The additive mutational effects from surface charge engineering: A compromise between enzyme activity, thermostability and ionic liquid tolerance, Biochemical Engineering Journal, 2019, 148,195-204.
[8] Ye Zhou, Nykola C. Jones, Jannik Nedergaard Pedersen, Bianca P8rez, S?ren Vr?nning Hoffmann, Steen Vang Petersen, Jan Skov Pedersen, Adam Perriman, Peter Kristensen, Renjun Gao*, and Zheng Guo*, Insight into the Structure and Activity of Surface-Engineered Lipase Biofluids, ChemBioChem, 2019, 20, 1266-1272.
[9] Jiabao Lyu, Zidan Li, Juncheng Men, Ruyun Jiang, Guilin Tang, Ye Zhou, Renjun Gao*, Covalent immobilization of Bacillus subtilis lipase A on Fe3O4 nanoparticles by aldehyde tag: An ideal immobilization with minimal chemical modification, Process Biochemistry, 2019, 81, 63-69.
[10] Dongni Liu, Wei Li, Xiaoyu Jiang, Shuju Bai, Jiyang Liu, Xutong Liu, Yuhua Shi, Ziyu Kuai, Wei Kong, Renjun Gao* and Yaming Shan*, Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer’s disease, Theranostics, 2019, 9(8), 2268-2281.
[11] Jingwen Yang, Renjun Gao, Ye Zhou, Sampson Anankanbil, Jingbo Li, Guiqiu Xie*, Zheng Guo*, β-Glucosidase from Thermotoga naphthophila RKU-10 for exclusive synthesis of galactotrisaccharides: Kinetics and thermodynamics insight into reaction mechanism, Food Chemistry, 2018, 240, 1:422-429
[12] Jingwen Yang, Bianca Pérez, Sampson Anankanbil, Jingbo Li, Ye Zhou, Renjun Gao*, Zheng Guo*, Valorizing Dairy Waste: Thermophilic Biosynthesis of a Novel Ascorbic Acid Derivative, Journal of Agricultural and Food Chemistry, 2017, 65(41): 9087-9093.
[13] Jingwen Yang, Qi Wang, Ye Zhou, Jingbo Li, Renjun Gao*, Zheng Guo*, Engineering T. naphthophila β-glucosidase for enhanced synthesis of galactooligosaccharides by site-directed mutagenesis, Biochemical Engineering Journal, 2017, 127, 15:1-8.
[14] Jingwen Yang, Bianca Pérez, Sampson Anankanbil, Jingbo Li, Renjun Gao*, and Zheng Guo*, Enhanced Synthesis of Alkyl Galactopyranoside by Thermotoga naphthophila β-Galactosidase Catalyzed Transglycosylation: Kinetic Insight of a Functionalized Ionic Liquid-Mediated System, ACS Sustainable Chem. Eng. 2017, 5, 2006-2014.
[15] Ye Zhou, Guiqiu Xie, Lin Chang, Yan Wang, Renjun Gao*, Identification of an archaeal maltooligosyltrehalose trehalohydrolase encoded by an interrupted gene, Extremophile, 2017, 21:537-549.
[16] Xiaoxiao Yu, Bianca Pérez, Zhefei Zhang, Renjun Gao* and Zheng Guo*, Mining catalytic promiscuity from Thermophilic archaea: an acyl-peptide releasing enzyme from Sulfolobus tokodaii (ST0779) for nitroaldol reactions, Green Chemistry, 2016, 18, 2753-2761.
[17] Jingwen Yang, Xiaochen Chen, Dahai Yu, Renjun Gao*. Microwave-assisted synthesis of butyl galactopyranoside catalyzed by β-galactosidase from thermotoga naphthophila RKU-10. Process Biochemistry, 2016, 51, 1: 53-58.
[18] Hui Jian, Yingwu Wang*, Yan Bai, Rong Li, Renjun Gao*, Site-Specific, Covalent Immobilization of Dehalogenase ST2570 Catalyzed by Formylglycine-Generating Enzymes and Its Application in Batch and Semi-Continuous Flow Reactors, Molecules, 2016, 21,7:895.