王磊 博士生导师
职称：教授
最高学位：博士
电话：13943085518
Email：w_lei@jlu.edu.cn
工作地点：生命科学楼279
微信公众号：JLU酶促有机合成
研究方向：
新型人工金属酶设计
仿生智能传感水凝胶
合成生物学在手性药物合成中应用
教育经历：1997-2001：吉林大学大学化学学院化学专业，获理学学士学位
2001-2006：吉林大学化学学院有机化学系，获理学博士学位
工作经历：2006 -2008：吉林大学分子酶学工程教育部重点实验室担任讲师
2008-2014：吉林大学分子酶学工程教育部重点实验室任副教授
2014-现在：吉林大学分子酶学工程教育部重点实验室任教授
2012-2013：美国阿克伦大学化学系，访问学者
研究成果：
近三年代表性文章：
1. Enzyme-Controlled Bidirectional Enantioselectivity in Asymmetric Decarboxylative Mannich Reaction for Synthesizing β-Sulfonamide Ketones. ACS Catal. 2025, 4784-4797. （中科院一区）
2. Enabling Desaturation of Lactones by Reversible Catalytic Activity of 'Ene'-reductases., Green Chem., 2025, （中科院一区）
3. Lipoic acid-based stable underwater adhesive with repeatable adhesion and recyclability, Chem. Eng. J., 2025, 512,162309. （中科院一区）.
4. Construction of Chiral Tricyclic Structures Using Whole-Cell Biocatalysts: A Strategy via the Cyclopropanation of Unsaturated π-Systems, Chin. J. Chem. 2025, 43, 2143-2150. （中科院一区）.
5. Electro-enzymatic cascade Stereodivergent Synthesis of β-hydroxy selenides via Engineered Ketoreductases, Org. Lett., 2025. （中科院一区，本科生一作）
6. Cellulose nanocomposite hydrogel-conductive, antimicrobial and high tenacity sensor for information encryption, human motion monitoring and animal behavior studies, Int. J. Biol. Macromol., 2025, 315, 144405. （中科院二区，本科生一作）
7. Xanthan gum-toughened nanocomposite conductive hydrogel for wearable sensors and smart livestock monitoring, Int. J. Biol. Macromol., 2025, 318, 144983. （中科院二区，本科生一作）
8. Machine-Learning-Aided Engineering Hemoglobin as Carbene Transferase for Catalyzing Enantioselective Olefin Cyclopropanation. JACS Au. 2024, 4 (12), 4957-4967. （中科院一区）.
9. Directed Evolution of Escherichia coli Surface-displayed Vitreoscilla Hemoglobin as an Artificial Metalloenzyme for the Synthesis of 5-Imino-1,2,4-thiadiazoles, Chem. Sci., 2024, 15, 7742 -7748. （中科院一区）.
10. Vitreoscilla hemoglobin: a natural carbene transfer catalyst for diastereo- and enantioselective synthesis of nitrile-substituted cyclopropanes. Green Chem., 2023, 25, 6853-6858. （中科院一区）.
11. Synthesis of Isothiocyanates from Primary Amines via Visible-Light Photocatalysis. Org. Lett. 2023, 25 (30), 5692-5696. （中科院一区）.
12. Engineering of Dual-Function Vitreoscilla Hemoglobin: A One-Pot Strategy for the Synthesis of Unnatural α-Amino Acids. Org. Lett. 2023, 25 (39), 7115-7119. （中科院一区）.
