王磊 博士生导师
职称：教授
最高学位：博士
电话：13943085518
Email：w_lei@jlu.edu.cn
工作地点：生命科学楼279
微信公众号：JLU酶促有机合成
研究方向：
新型人工金属酶设计
仿生智能传感水凝胶
合成生物学在手性药物合成中应用
教育经历：1997-2001：吉林大学大学化学学院化学专业，获理学学士学位
2001-2006：吉林大学化学学院有机化学系，获理学博士学位
工作经历：2006 -2008：吉林大学分子酶学工程教育部重点实验室担任讲师
2008-2014：吉林大学分子酶学工程教育部重点实验室任副教授
2014-现在：吉林大学分子酶学工程教育部重点实验室任教授
2012-2013：美国阿克伦大学化学系，访问学者
研究成果：
近三年代表性文章：
(1) Photo-Enzymatic Cascade Catalysis with an Artificial CDCase for Stereoselective Cross-Dehydrogenative Coupling, ACS catalysis, 2026, 16, 4, 3508–3521.
(2) From Bio-interface Materials to Neural Integration: The Next-generation Brain-machine Interfaces Powered by Hydrogels, Advanced Materials, 2026, 38(31): e23422.
(3) Low‑Temperature‑Induced Recombinant Talin Assembly into Energy‑Dissipative Hydrogels for Machine Learning‑Powered Multimodal Sports Monitoring, Biosensors and Bioelectronics, 2026, 309, 118808.
(4) Sweat-resistant and highly adhesive hydrogel skin electrodes for machine learning guided sports training and exercise monitoring, Carbohydrate Polymers, 378 (2026) 124942.
(5) Cyclodesulfurization Reaction Catalyzed by Artificial Metalloenzymes Containing Cobalt Protoporphyrin IX Cofactors under Green Aqueous Solvent Conditions, Green Chemistry, 2026, 28, 2622–2628.
(6) Enabling Desaturation of Lactones by Reversible Catalytic Activity of 'Ene'-reductases, Green Chemistry, 2025, 27, 7229-7233.
(7) Electroenzymatic Cascade Synthesis of Chiral α-Substituted Aromatic Halohydrins from Styrene: A Green and Stereoselective Approach, Green Chemistry, 2025, 27, 15582–15587. (本科生一作)
(8) Enzyme-Controlled Bidirectional Enantioselectivity in Asymmetric Decarboxylative Mannich Reaction for Synthesizing β-Sulfonamide Ketones, ACS Catalysis, 2025, 15, 4784-4797.
(9) Efficient Artificial Cu(II)-Diels-Alderase Base on Streptavidin for Highly Enantio- and Regioselective Diels-Alder Reactions. ACS Catalysis, 2025, 15, 17726-17737.
(10) Electro-enzymatic cascade Stereodivergent Synthesis of β-hydroxy selenides via Engineered Ketoreductases, Organic Letters, 2025, 27, 6842-6847. （本科生一作）
(11) Directed Evolution of Escherichia coli Surface-displayed Vitreoscilla Hemoglobin as an Artificial Metalloenzyme for the Synthesis of 5-Imino-1,2,4-thiadiazoles, Chemical Science, 2024, 15, 7742 -7748.
(12) Machine-learning-aided engineering hemoglobin as carbene transferase for catalyzing enantioselective olefin cyclopropanation, JACS Au, 2024, 4, 4957−4967.
