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微生物学与免疫学系

姜春来

日期:2020-08-11 点击数: 来源:


姜春来


姓名: 姜春来
职称: 教授
最高学位: 博士
电话:
Email:
工作地点: 生命科学楼 405


研究方向: 1、病原微生物致病分子机制研究 2、新型疫苗研究与开发
教育经历: 1991~1995,四川大学,理学学士
1997~2000,长春生物制品所,医学免疫学硕士
2001~2005,吉林大学,生物化学和分子生物学博士

工作经历: 1、2006~2009,美国杜克大学,博士后
2、2001至今,吉林大学,生命科学学院、艾滋病疫苗国家工程实验室,讲师、教授
研究成果:

1: Wan M, Yang X, Sun J, Ding X, Chen Z, Su W, Cai L, Hou A, Sun B, Gao F, Jiang C, Zhou Y. An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model. Viruses. 2023 Jan 13;15(1):219. doi: 10.3390/v15010219. PMID: 36680259; PM CID: PMC9861952.


2: Wan M, Yang X, Chen Z, Su W, Cai L, Hou A, Sun B, Zhang Y, Kong W, Jiang C, Zhou Y. Comparison of effects of multiple adjuvants and immunization routes on the immunogenicity and protection of HSV-2 gD subunit vaccine. Immunol Lett. 2023 Aug;260:11-21. doi: 10.1016/j.imlet.2023.06.004. Epub 2023 Jun 7. PMID: 37290556.


3: Liu H, Jiang C, Wu Y, Wu M, Wu J, Zhao G, Sun J, Huang X, Li J, Sheng R, Barbier J, Cintrat JC, Gillet D, Su W. Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy. Int J Mol Sci. 2022 Apr 1;23(7):3940. doi: 10.3390/ijms23073940. PMID: 35409297; PMCID: PMC8999625.


4: Liu J, Lin J, Cai L, Sun J, Ding X, Wang C, Wu Y, Gao X, Su W, Jiang C. Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice. Viruses. 2022 Jun 2;14(6):1214. doi: 10.3390/v14061214. PMID: 35746685; PMCID: PMC9230688.


5: Bian L, Zheng Y, Guo X, Li D, Zhou J, Jing L, Chen Y, Lu J, Zhang K, Jiang C, Zhang Y, Kong W. Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice. Front Immunol. 2022 Jul 22;13:938598. doi: 10.3389/fimmu.2022.938598. PMID: 35935960; PMCID: PMC9354885.


6: Wu M, Zhou E, Sheng R, Fu X, Li J, Jiang C, Su W. Defective Interfering Particles of Influenza Virus and Their Characteristics, Impacts, and Use in Vaccines and Antiviral Strategies: A Systematic Review. Viruses. 2022 Dec 12;14(12):2773. doi: 10.3390/v14122773. PMID: 36560777; PMCID: PMC9781619.


7: Zhao S, Zheng B, Wang L, Cui W, Jiang C, Li Z, Gao W, Zhang W. Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners. Chin Med J (Engl). 2022 Nov 20;135(22):2706-2717. doi: 10.1097/CM9.0000000000002478. PMID: 36574218; PMCID: PMC9945250.


8: Gao W, Li G, Zhao S, Wang H, Huan C, Zheng B, Jiang C, Zhang W. Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression. J Virol. 2021 Jun 10;95(13):e0046021. doi: 10.1128/JVI.00460-21. Epub 2021 Jun 10. PMID: 33827943; PMCID: PMC8316079.


9: He L, Sun B, Guo Y, Yan K, Liu D, Zang Y, Jiang C, Zhang Y, Kong W. Immune response of C57BL/6J mice to herpes zoster subunit vaccines formulated with nanoemulsion-based and liposome-based adjuvants. Int Immunopharmacol. 2021 Dec;101(Pt B):108216. doi: 10.1016/j.intimp.2021.108216. Epub 2021 Oct 8. Erratum in: Int Immunopharmacol. 2023 Jun;119:110260. PMID: 34634689.


10: Yang X, Wan M, Cai L, Hou A, Sun B, Zhou Y, Gao F, Su W, Jiang C. Interferon Inhibition Enhances the Pilot-Scale Production of Rabies Virus in Human Diploid MRC-5 Cells. Viruses. 2021 Dec 29;14(1):49. doi: 10.3390/v14010049. PMID: 35062253; PMCID: PMC8779192.


11: Cao J, Qu M, Liu H, Wan X, Li F, Hou A, Zhou Y, Sun B, Cai L, Su W, Jiang C. Myristoylation of EV71 VP4 is Essential for Infectivity and Interaction with Membrane Structure. Virol Sin. 2020 Oct;35(5):599-613. doi: 10.1007/s12250-020-00226-1. Epub 2020 May 12. PMID: 32399947; PMCID: PMC7736455.


12: Zheng Y, Bian L, Zhao H, Liu Y, Lu J, Liu D, Zhang K, Song Y, Luo Y, Jiang C, Chen Y, Zhang Y, Kong W. Respiratory Syncytial Virus F Subunit Vaccine With AS02 Adjuvant Elicits Balanced, Robust Humoral and Cellular Immunity in BALB/c Mice. Front Immunol. 2020 Sep 11;11:526965. doi: 10.3389/fimmu.2020.526965. PMID: 33013922; PMCID: PMC7516270.


13: Yang P, Chen Z, Zhang J, Li W, Zhu C, Qiu P, Quan Y, Cui X, Yuan L, Jiang C. Evaluation of Varicella-zoster virus-specific cell-mediated immunity by interferon-γ Enzyme-Linked Immunosorbent Assay in adults ≥50 years of age administered a herpes zoster vaccine. J Med Virol. 2019 May;91(5):829-835. doi: 10.1002/jmv.25391. Epub 2019 Jan 12. PMID: 30613990.


14: Wang J, Wu F, Liu C, Dai W, Teng Y, Su W, Kong W, Gao F, Cai L, Hou A, Jiang C. Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process. Virol Sin. 2019 Feb;34(1):59-65. doi: 10.1007/s12250-019-00087-3. Epub 2019 Feb 6. PMID: 30725320; PMCID: PMC6420551.


15:  Wang J, Teng Y, Zhao G, Li F, Hou A, Sun B, Kong W, Gao F, Cai L, Jiang C. Exosome-Mediated Delivery of Inducible miR-423-5p Enhances Resistance of MRC-5 Cells to Rabies Virus Infection. Int J Mol Sci. 2019 Mar 27;20(7):1537. doi: 10.3390/ijms20071537. PMID: 30934732; PMCID: PMC6479321.


16: Dai W, Bi J, Li F, Wang S, Huang X, Meng X, Sun B, Wang D, Kong W, Jiang C, Su W. Antiviral Efficacy of Flavonoids against Enterovirus 71 Infection in Vitro and in Newborn Mice. Viruses. 2019 Jul 7;11(7):625. doi: 10.3390/v11070625. PMID: 31284698; PMCID: PMC6669683.


17: Cao J, Liu H, Qu M, Hou A, Zhou Y, Sun B, Cai L, Gao F, Su W, Jiang C. Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly. Microb Pathog. 2019 Sep;134:103568. doi: 10.1016/j.micpath.2019.103568. Epub 2019 Jun 11. PMID: 31195113.


18: Wang C, Gao N, Song Y, Duan S, Wang W, Cong Z, Qin C, Jiang C, Yu X, Gao F. Reduction of peak viremia by an integration-defective SIV proviral DNA vaccine in rhesus macaques. Microbiol Immunol. 2020 Jan;64(1):52-62. doi: 10.1111/1348-0421.12744. Epub 2019 Oct 14. PMID: 31544982.


19: Shi W, Kou Y, Xiao J, Zhang L, Gao F, Kong W, Su W, Jiang C, Zhang Y. Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants. Vaccine. 2018 Aug 9;36(33):5020-5029. doi: 10.1016/j.vaccine.2018.07.006. Epub 2018 Jul 7. PMID: 30037417.


20: Kou Y, Wan M, Shi W, Liu J, Zhao Z, Xu Y, Wei W, Sun B, Gao F, Cai L, Jiang C. Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. J Microbiol Biotechnol. 2018 Jun 28;28(6):1022-1029.
doi: 10.4014/jmb.1712.12064. PMID: 29847865.

21: Song H, Giorgi EE, Ganusov VV, Cai F, Athreya G, Yoon H, Carja O, Hora B, Hraber P, Romero-Severson E, Jiang C, Li X, Wang S, Li H, Salazar-Gonzalez JF, Salazar MG, Goonetilleke N, Keele BF, Montefiori DC, Cohen MS, Shaw GM, Hahn BH, McMichael AJ, Haynes BF, Korber B, Bhattacharya T, Gao F. Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection. Nat Commun. 2018 May 15;9(1):1928.
doi: 10.1038/s41467-018-04217-5. PubMed PMID: 29765018; PubMed Central PMCID: PMC5954121.

22: Shi W, Kou Y, Jiang H, Gao F, Kong W, Su W, Xu F, Jiang C. Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. Immunol Lett. 2018 Jun;198:26-32.
doi: 10.1016/j.imlet.2018.03.012. Epub 2018 Mar 27. PubMed PMID: 29601940.

23: Dai W, Wu Y, Bi J, Wang S, Li F, Kong W, Barbier J, Cintrat JC, Gao F, Gillet D, Su W, Jiang C. Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. Viruses. 2018 Mar 9;10(3).
pii: E119. doi: 10.3390/v10030119. PubMed PMID: 29522484; PubMed Central PMCID: PMC5869512.

24: Wang D, Lu J, Yu J, Hou H, Leenhouts K, Van Roosmalen ML, Gu T, Jiang C, Kong W, Wu Y. A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like ParticlesProvides Broad Protection Against Pneumococcal Pneumonia in Mice. Immunol Invest. 2018 May;47(4):403-415.
doi: 10.1080/08820139.2018.1439505. Epub 2018 Mar 2. PubMed PMID: 29498560.

25: Du X, Zhang X, Jiang C, Zhang W, Yang L. The Trace Detection of Nitrite Ions Using Neutral Red Functionalized SH-β-Cyclodextrin @Au Nanoparticles. Sensors (Basel). 2018 Feb 25;18(3).
pii: E681. doi: 10.3390/s18030681. PubMed PMID: 29495331; PubMed Central PMCID: PMC5877208.

26: Zhao D, Sun B, Sun S, Fu B, Liu C, Liu D, Chu Y, Ma Y, Bai L, Wu Y, Zhou Y, Su W, Hou A, Cai L, Xu F, Kong W, Jiang C. Characterization of human enterovirus71 virus-like particles used for vaccine antigens. PLoS One. 2017 Jul 21;12(7):e0181182.
doi: 10.1371/journal.pone.0181182. eCollection 2017. PubMed PMID: 28732070; PubMed Central PMCID: PMC5521781.

27: Kou Y, Xu Y, Zhao Z, Liu J, Wu Y, You Q, Wang L, Gao F, Cai L, Jiang C. Tissue plasminogen activator (tPA) signal sequenceenhancesimmunogenicity of MVA-based vaccine against tuberculosis. Immunol Lett. 2017 Oct;190:51-57. doi: 10.1016/j.imlet.2017.07.007. Epub 2017 Jul 17. PubMed PMID: 28728855.

28: Dai W, Wu Y, Bi J, Lu X, Hou A, Zhou Y, Sun B, Kong W, Barbier J, Cintrat JC, Gao F, Gillet D, Su W, Jiang C. Antiviral effects of Retro-2(
cycl) and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug;144:311-321. doi: 10.1016/j.antiviral.2017.07.001. Epub 2017 Jul 5. PubMed PMID: 28688753.

29: Zhou Y, Wang Z, Xu Y, Zhang Z, Hua R, Liu W, Jiang C, Chen Y, Yang W, Kong W. Optimized DNA Vaccine Enhanced by Adjuvant IL28B Induces Protective Immune Responses Against Herpes Simplex Virus Type 2 in Mice. Viral Immunol. 2017 Oct;30(8):601-614. doi: 10.1089/vim.2017.0033. Epub 2017 Jun 26. PubMed PMID: 28650722.

30: Su W, Li X, Chen M, Dai W, Sun S, Wang S, Sheng X, Sun S, Gao C, Hou A, Zhou Y, Sun B, Gao F, Xiao J, Zhang Z, Jiang C. Synonymous codon usage analysis of hand,footand mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015. Infect Genet Evol. 2017 Sep;53:212-217. doi: 10.1016/j.meegid.2017.06.004. Epub 2017 Jun 15. PubMed PMID: 28602802.

31: Wang C, Jiang C, Gao N, Zhang K, Liu D, Wang W, Cong Z, Qin C, Ganusov VV, Ferrari G, LaBranche C, Montefiori DC, Kong W, Yu X, Gao F. Immunologic and Virologic Mechanisms for Partial Protection from Intravenous Challenge by an Integration-Defective SIV Vaccine. Viruses. 2017 Jun 2;9(6). pii: E135. doi: 10.3390/v9060135. PubMed PMID: 28574482; PubMed Central PMCID: PMC5490812.

32: Lu J, Hou H, Wang D, Leenhouts K, Roosmalen MLV, Sun T, Gu T, Song Y, Jiang C, Kong W, Wu Y. Systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant Plym2. Immunol Lett. 2017 Jul;187:41-46. doi: 10.1016/j.imlet.2017.05.003. Epub 2017 May 6. PubMed PMID: 28487097.

33: Xi H, Zhang K, Yin Y, Gu T, Sun Q, Li Z, Cheng Y, Jiang C, Kong W, Wu Y. Engineering of a novel zipFv using leucine zipper motif against rabies virus glycoprotein G with improved protection potency in vivo. Immunol Lett. 2017 Jun;186:9-14. doi: 10.1016/j.imlet.2017.04.001. Epub 2017 Apr 4. PubMed PMID: 28389318.

34: Liu W, Zhou Y, Wang Z, Zhang Z, Wang Q, Su W, Chen Y, Zhang Y, Gao F, Jiang C, Kong W. Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. Microbiol Immunol. 2017 May;61(5):176-184.doi: 10.1111/1348-0421.12482. PubMed PMID: 28378925.

35: Jin J, Li R, Jiang C, Zhang R, Ge X, Liang F, Sheng X, Dai W, Chen M, Wu J, Xiao J, Su W. Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells. BMC Genomics. 2017 Jan 25;18(Suppl 1):933. doi: 10.1186/s12864-016-3253-6. PubMed PMID: 28198671; PubMed Central PMCID: PMC5310284.

36: Xi H, Zhang K, Yin Y, Gu T, Sun Q, Shi L, Zhang R, Jiang C, Kong W, Wu Y. Fusion Peptide Improves Stability and Bioactivity of Single Chain Antibody against Rabies Virus. J Microbiol Biotechnol. 2017 Apr 28;27(4):718-724. doi: 10.4014/jmb.1611.11062. PubMed PMID: 28068664.

37: Shen Z, Bowen RA, Ge P, Yu J, Shen Y, Kong W, Jiang C, Wu J, Zhu C, Xu Y, Wei W, Rudenko L, Kiseleva I, Xu F. Evaluation of a candidate live attenuated influenza vaccine prepared in Changchun BCHT (China) for safety and efficacy in ferrets. Vaccine. 2016 Nov 21;34(48):5953-5958. doi: 10.1016/j.vaccine.2016.09.059. Epub 2016 Oct 26. PubMed PMID: 27997342.

38: Wang D, Di X, Fu L, Li Y, Han X, Wu H, Cai L, Meng X, Jiang C, Kong W, Su W. Analysis of serum β-amyloid peptides, α2-macroglobulin, complement factor H, and clusterin levels in APP/PS1 transgenic miceduringprogression of Alzheimer's disease. Neuroreport. 2016 Oct 19;27(15):1114-9. doi: 10.1097/WNR.0000000000000661. PubMed PMID: 27541273.

39: Xi H, Yuan R, Chen X, Gu T, Cheng Y, Li Z, Jiang C, Kong W, Wu Y. Purification and on-column refolding of a single-chain antibody fragment against rabies virus glycoprotein expressed in Escherichia coli. Protein Expr Purif. 2016 Oct;126:26-32.doi: 10.1016/j.pep.2016.05.004. Epub 2016 May 5. PubMed PMID: 27157441.

40: Li X, Fan P, Jiang C, Ma T, Yu X, Kong W, Gao F. High-Frequency Illegitimate Strand Transfers of Nascent DNA Fragments During Reverse Transcription Result in Defective Retrovirus Genomes. J Acquir Immune Defic Syndr. 2016 Aug 1;72(4):353-62. doi: 10.1097/QAI.0000000000000952. PubMed PMID: 26885810.

41: Gong X, Yin H, Shi Y, Guan S, He X, Yang L, Yu Y, Kuai Z, Jiang C, Kong W, Wang S, Shan Y. Conserved stem fragment from H3 influenza hemagglutinin elicits cross-clade neutralizing antibodies through stalk-targeted blocking of conformational change during membrane fusion. Immunol Lett. 2016 Apr;172:11-20. 
doi: 10.1016/j.imlet.2016.02.006. Epub 2016 Feb 10. PubMed PMID: 26875772.

42: Jiang L, Fan R, Sun S, Fan P, Su W, Zhou Y, Gao F, Xu F, Kong W, Jiang C. A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice. Vaccine. 2015 Nov 27;33(48):6596-603. doi: 10.1016/j.vaccine.2015.10.104. Epub 2015 Oct 31. PubMed PMID: 26529072.

43: Cheng Y, Li Z, Xi H, Gu T, Yuan R, Chen X, Jiang C, Kong W, Wu Y. A VL-linker-VH Orientation Dependent Single Chain Variable Antibody Fragment Against Rabies Virus G Protein with Enhanced Neutralizing Potency in vivo. Protein Pept Lett. 2016;23(1):24-32. PubMed PMID: 26497316.

44: Sun B, Zhao D, Zhang X, Gu T, Yu X, Sun S, Zhao X, Wei L, Liu D, Yan H, Meng X, Kong W, Xu F, Yang P, Jiang C. Development
a scalable production process for truncated human papillomavirus type-6 L1 protein using WAVE Bioreactor and hollow fiber membrane. Appl Microbiol Biotechnol. 2016 Feb;100(3):1231-40. doi: 10.1007/s00253-015-6974-6. Epub 2015 Oct 8. PubMed PMID: 26446387.

45: Li Z, Cheng Y, Xi H, Gu T, Yuan R, Chen X, Jiang C, Kong W, Wu Y. A novel variable antibody fragment dimerized by leucine zippers with enhanced neutralizing potency against rabies virus G protein compared to its corresponding single-chain variable antibody fragment. Mol Immunol. 2015 Dec;68(2 Pt A):168-75. doi: 10.1016/j.molimm.2015.06.027. Epub 2015 Aug 29. PubMed PMID: 26325475.

46: Qi Y, Zhang F, Zhang L, Harrison TJ, Huang W, Zhao C, Kong W, Jiang C, Wang Y. Hepatitis E Virus Produced from Cell Culture Has a Lipid Envelope. PLoS One. 2015 Jul 10;10(7):e0132503.
doi: 10.1371/journal.pone.0132503. eCollection 2015. PubMed PMID: 26161670; PubMed Central PMCID: PMC4498737.

47: Zang Y, Du D, Li N, Su W, Liu X, Zhang Y, Nie J, Wang Y, Kong W, Jiang C. Eliciting neutralizing antibodies againstthemembrane proximal external region of HIV-1 Env by chimeric live attenuated influenza A virus vaccines. Vaccine. 2015 Jul 31;33(32):3859-64. doi: 10.1016/j.vaccine.2015.06.072. Epub 2015 Jun 28. PubMed PMID: 26126669.

48: Lu J, Sun T, Wang D, Dong Y, Xu M, Hou H, Kong FT, Liang C, Gu T, Chen P, Sun S, Lv X, Jiang C, Kong W, Wu Y. Protective Immune Responses Elicited by Fusion Protein Containing PsaA and PspA Fragments. Immunol Invest. 2015;44(5):482-96. 
doi: 10.3109/08820139.2015.1037956. PubMed PMID: 26107747.

49: Sun S, Gao F, Mao Q, Shao J, Jiang L, Liu D, Wang Y, Yao X, Wu X, Sun B, Zhao D, Ma Y, Lu J, Kong W, Jiang C, Liang Z. Immunogenicity and protective efficacy of an EV71 virus-like particle vaccine against lethal challenge in newborn mice. Hum Vaccin Immunother. 2015;11(10):2406-13.
doi: 10.1080/21645515.2015.1053675. PubMed PMID: 26036916; PubMed Central PMCID: PMC4635907.

50: Fan P, Li X, Su W, Kong W, Kong X, Wang Z, Wang Y, Jiang C, Gao F. Enhanced Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked Fluorescence Oligonucleotide Assay. PLoS One. 2015 Apr 27;10(4):e0125701. doi: 10.1371/journal.pone.0125701. eCollection 2015. PubMed PMID: 25915630; PubMed Central PMCID: PMC4410951.


近五年发表SCI收入论文50多篇,获授权发明专利7项。主持“十二五”国家科技重大专项子课题1项,国家自然科学面上基金1项,吉林省科技厅重大科技攻关招标项目、重点项目及产业化项目各1项,长春市产学研协同创新示范点建设专项1项,累计到款科研经费超过500万。获得省部级科研学术奖励3项。