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微生物学与免疫学系

于湘晖

日期:2020-08-11 点击数: 来源:


于湘晖


姓名: 于湘晖
职称: 教授
最高学位: 博士
电话:
Email:
工作地点: 生命科学楼401


研究方向: 1. 艾滋病病毒(HIV)感染机制研究:Serinc等宿主蛋白抗HIV-1分子机制研究;以病毒与宿主蛋白相互作用为靶点的多肽类抑制剂和药物前体化合物设计与筛选;利用基于CRISPR-Cas9方法进行全基因组筛选影响HIV-1复制传播的宿主限制因子 2. 新型艾滋病疫苗设计与临床研究:基于BLP等新型佐剂的HIV-1蛋白疫苗设计与评价;可诱导广谱中和抗体的新型HIV-1疫苗设计
教育经历: 1999/09-2003/12,吉林大学,生物化学与分子生物学,博士
1994/09-1997/07,吉林大学,生物化学与分子生物学,硕士
1990/09-1994/07,吉林大学,生物化学与分子生物学,学士
工作经历: 2008/06 - 至今,吉林大学,艾滋病疫苗国家工程实验室,教授
2003/12 - 至今,吉林大学,生命科学学院,教授
2001/03 - 2003/12,美国约翰霍普金斯大学,公共卫生学院,访问学者
荣誉称号: 吉林省“长白山学者”、教育部“新世纪人才”、吉林大学“唐敖庆”特聘教授、吉林省拔尖创新人才、第四届中国青年女科学家奖提名奖、
研究成果: 主持科研项目:
1.“十三五”国家科技重大专项课题,2018ZX09301053-004 , 新型靶向溶瘤腺病毒治疗复发转移性乳腺癌临床前研究,2018/06-2020/12,300万元,运行,主持
2. 国家自然科学基金面上项目,81472816,衣壳蛋白基因修饰溶瘤腺病毒基因治疗载体的设计和治疗恶性肿瘤的研究,2015/01-2018/12,72万元,运行,主持
3.国家自然科学基金面上项目,31270807,钙离子介导的HIV-1 Vpu拮抗Tetherin作用机制的研究,2013/01-2016/12,80万元,结题,主持
4.“十二五”国家科技重大专项子课题,2013ZX10004608-003,艾滋病新型靶标病毒构建及比较医学研究关键技术创建,2013/01-2015/12,73.62万元,结题,主持
5.“十二五”国家科技重大专项子课题,2012ZX10001-009-07,DNA疫苗质量标准和临床样品生产2012/01-2015/12,200万元,结题,主持
6. 国家自然科学基金面上项目,30872396,六邻体嵌合型rAd5载体逃避机体预存免疫的机制,2009/01-2011/12,30万元,结题,主持
代表性期刊论文:
1.Nan Gao#, Wei Wang#, Chu Wang#, Tiejun Gu, Rui Guo, Bin Yu, Wei Kong, Chuan Qin, Elena E Giorgi, Zhiwei Chen, Samantha Townsley, Shiu-Lok Hu, Xianghui Yu*, Feng Gao*. Development of broad neutralization activity in simian/human immunodeficiency virus-infected rhesus macaques after long-term infection, AIDS, 2018; 32(5): 555-563.
2.Di Liu, Lin Liu, Lizheng Wang, Sizhu Duan, Yanan Song, Meng Qu, Nan Gao, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*, Therapeutic effects of mesenchymal stem cells combined with short hairpin RNA on liver injury induced by hepatitis B virus infection, Mol Med Rep. 2018; 17(1): 1731-1741
3.Weiran Wang, Meng Qu, Jiawen Wang, Xin Zhang, Haihong Zhang, Jiaxin Wu, Bin Yu, Hui Wu, Wei Kong*, Xianghui Yu*, Autoubiquitination of feline E3 ubiquitin ligase BCA2. Gene, 2018, 638:1-6
4.Lizheng Wang, Zixuan Wang, Rui Zhu, Jinpeng Bi, Xinyao Feng, Wenmo Liu, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*, Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression, PLoS One, 2017, 12(6):e0179476
5.Chu Wang, Chunlai Jiang, Nan Gao, Kaikai Zhang, Donglai Liu, Wei Wang, Zhe Cong, Chuan Qin, Vitaly V. Ganusov, Guido Ferrari, Celia LaBranche, David C. Montefiori, Wei Kong, Xianghui Yu *, Feng Gao*, Immunologic and Virologic Mechanisms for Partial Protection from Intravenous Challenge by an Integration-Defective SIV Vaccine, Viruses. 2017, 9(6): 135
6.4.Lu Fu, Yingnan Li, Yue Hu, Yayuan Zheng, Bin Yu, Haihong Zhang, Jiaxin Wu, Hui Wu*, Xianghui Yu*, Wei Kong*, A norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in mouse model of Alzheimer’s disease. Scientific Reports, 2017, 7: 41041
7.Shuai Lang, Lizheng Wang, Zixuan Wang, Rui Zhu, Jingyi Yan, Baoming Wang, Jiaxin Wu, Haihong Zhang, Hui Wu, Yan Zhou, Wei Kong, Bin Yu*, Xianghui Yu*, Localization of neutralization epitopes on adenovirus fiber knob from species C, Journal of General Virology, 2016, 97(4):955-62
8.Jingyi Yan,Lizheng Wang,Zixuan Wang,Zhen Wang,Baoming Wang,Rui Zhu,Jinpeng Bi,Jiaxin Wu,Haihong Zhang,Hui Wu,Bin Yu*,Wei Kong,Xianghui Yu*,Engineered adenovirus fibershaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumoractivity, Cell Death and Disease, 2016, 7(6) : e2274
9.Haihong Zhang, Chenlu Liu, Fangfang Zhang, Fei Geng, Qiu Xia, Zhenzhen Lu, Ping Xu, Yu Xie, Hui Wu, Bing Yu, Jiaxin Wu, Xianghui Yu*, Wei Kong*. MUC1 and survivin combination tumor gene vaccine generates specific immune responses and anti-tumor effects in a murine melanoma model. Vaccine, 2016, 34(24): 2648-2655
10.Zhen Wang, Bin Yu, Baoming Wang, Jingyi Yan, Xiao Feng, Zixuan Wang, Lizheng Wang, Haihong Zhang, Hui Wu, Jiaxin Wu, Wei Kong*, Xianghui Yu*, A novel capsid-modifiedoncolytic recombinant adenovirus type 5 for tumor-targeting gene therapy byintravenous route, Oncotarget, 2016, 7(30) : 47287-47301
11.Jingyi Yan, Jianing Dong, Jiaxin Wu, Rui Zhu, Zhen Wang, Baoming Wang, Lizheng Wang, Zixuan Wang, Haihong Zhang, Hui Wu, Bin Yu*, Wei Kong, Xianghui Yu*, Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors, Scientific Reports, 2016, 6:22464-22464
12.Weiran Wang, Jiawen Wang, Meng Qu, Xiaojun Li, Jingyao Zhang, Haihong Zhang,Jiaxin Wu, Bin Yu, Hui Wu, Wei Kong*, Xianghui Yu*, Viral Restriction Activity of Feline BST2 Is Independent of Its N-Glycosylation and Induction of NF-kappa B Activation, PLoS One, 2015, 10(9):e0138190
13.Xiaodan Wang, Xiaoying Wang, Weiran Wang, Jingyao Zhang, Jiawen Wang, Chu Wang, Mingyu Lv, Tao Zuo, Donglai Liu, Haihong Zhang, Jiaxin Wu, Bin Yu, Wei Kong, Hui Wu*, Xianghui Yu*, Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro, Biochem Biochemical and Biophysical Research Communications, 2015, 461(4):624-9
14.Jingyao Zhang, Jiaxin Wu, Weiran Wang, Hui Wu, Bin Yu, Jiawen Wang, Mingyu Lv, Xiaodan Wang, Haihong Zhang, Wei Kong*, Xianghui Yu*, Role of cullin-elonginB-elonginC E3 complex in bovine immunodeficiency virus and maedi-visna virus Vif-mediated degradation of host A3Z2-Z3 proteins,Retrovirology, 2014, 11(1): 77
15.Xiaodan Wang, Xiaoying Wang, Haihong Zhang, Mingyu Lv, Tao Zuo, Hui Wu, Jiawen Wang, Donglai Liu, Chu Wang, Jingyao Zhang, Xu Li, Jiaxin Wu, Bin Yu, Wei Kong*, Xianghui Yu*, Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-beta binding to Vif. Retrovirology, 2013, 10: 94-94
16.Tao Zuo, Donglai Liu, Wei Lv, Xiaodan Wang, Jiawen Wang, Mingyu Lv, Wenlin Huang, Jiaxin Wu, Haihong Zhang, Hongwei Jin, Liangren Zhang, Wei Kong*, Xianghui Yu*, Small-molecule inhibition of human immunodeficiency virus type 1 replication by targeting the interaction between Vif and ElonginC, J Virol, 2012, 86(10): 5497-5507
17.Jiawen Wang, Wenyan Zhang, Mingyu Lv, Tao Zuo, Wei Kong* and Xianghui Yu*. Identification of a Cullin5-ElonginB-ElonginC E3 Complex in Degradation of Feline Immunodeficiency Virus Vif-Mediated Feline APOBEC3 Proteins. J Virol. 2011, 85(23):12482-91.
18.Xianghui Yu, Yunkai Yu, Bindong Liu, Kun Luo, Wei Kong, Panyong Mao, Xiao-Fang Yu*, Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex, Science, 2003, 302(5647): 1056-1060
获得学术奖励:
1.于湘晖(4/5),艾滋病病毒与宿主天然防御因子相互作用新机制的研究,国家自然科学奖,二等奖,2017(于晓方,张文艳,杜娟,于湘晖,赵可)
2.于湘晖(1/10),艾滋病病毒辅助蛋白与宿主限制因子相互作用研究,吉林省自然科学学术成果奖评审委员会,吉林省自然科学学术成果奖,一等奖,2014(于湘晖,孔维,吴嘉昕,张海红,吴慧,于彬,王晓丹,左陶,吕铭宇,王佳雯)
3.于湘晖(2/10),HIV感染机制和人体对HIV免疫保护机制的研究,吉林省科技厅,吉林省科学技术奖,一等奖,2013(孔维,于湘晖,姜春来,吴永革,陈妍,单亚明,张喜珍,张海红,于彬,吴嘉昕)
4.于湘晖(2/10),腺病毒载体的预存免疫及解决策略的相关研究,吉林省自然科学学术成果奖评审委员会,吉林省自然科学学术成果奖,二等奖,2013(孔维,于湘晖,吴永革,姜春来,于彬,张喜珍,张海红,吴嘉昕,陈妍)
5.孔维(2/5),宫颈癌HPV感染、病毒基因突变以及DNA疫苗的非病毒载体构建,中国抗癌协会,中国抗癌协会科技奖,三等奖,2009(查晓,孔维,于湘晖,张国楠,乌恩齐
授权发明专利:
1.孔维、张海红、于湘晖、于永慧,以粘蛋白1和生存素为靶点的肿瘤DNA疫苗和病毒载体疫苗,2015.01.07,中国,ZL200910252427.x
2.孔维、张一折、姜春来、吴永革、于湘晖,冻干剂型艾滋病重组痘病毒安卡拉株载体疫苗及其制备方法,2007.06.20,中国,ZL200510016800.3