师资队伍

微生物学与免疫学系

苏维恒

日期:2020-08-11 点击数: 来源:
姓名:
苏维恒

职称: 副教授
最高学位: 博士
电话: 0431-89228979
E-mail: suweiheng@jlu.edu.cn
工作地点: 生命科学楼409室


研究方向:

病毒感染疾病自古以来就是人类健康的重大威胁。即使在科技发达的今天,冠状病毒肺炎、流感、艾滋病、手足口病等,仍然让人避之不及。人类对病毒的了解和掌控仍然远未够深入,这也是病毒学者的奋斗目标。 本课题组聚焦于手足口病(肠道病毒)、流感病毒、疱疹病毒HSV-2等,开展:1,分子病毒学、免疫学研究,阐明病毒的感染和致病机制;2,抗病毒药物发现,筛选和评价具有抗病毒活性的化合物及草药提取物,为药物开发提供候选。

本人主持国家自然科学基金面上项目、国家“十二五科技重大专项子课题”等国家级、省级科研项目累计11项;在Cell、Plos Pathogens、Antiviral Research等杂志上发表SCI论文累计43篇,其中通讯作者和第一作者SCI论文18篇;申请专利6项。

教育经历: 2001年-2005年,内蒙古大学,生命科学学院,学士。专业:生物技术
2006年-2011年,东北师范大学,生命科学学院,硕博连读博士。专业:细胞生物学。导师:麻彤辉教授(国家杰出青年基金、长江学者特聘)
工作经历: 2011年-2014年,吉林大学,生命科学学院,艾滋病疫苗国家工程实验室,讲师
2011年-2015年,中科院长春应用化学研究所,电分析化学国家重点实验室,博士后。学科:分析化学。合作导师:王宏达研究员(国家杰出青年基金,中科院百人计划)
2014年-至 今,吉林大学,生命科学学院,艾滋病疫苗国家工程实验室,副教授
2018年-2019年,美国加州大学旧金山分校(University of California, San Francisco),医学院微生物与免疫系,访问学者。合作导师:Raul Andino教授(获2017年The Academy Beijerinck Virology Prize)
研究成果:

主持的科研项目


1. 国家自然科学基金委员会,面上项目,32070932,流感减毒活疫苗中缺损干扰颗粒(DIP)对减毒和免疫激活的作用和研究机制,2021/01-2024/12,58万元,在研,主持

2. 内蒙古自治区科技计划项目,2020GG0233,沙黄清疫丸药效学研究,2020/7- 2023/6,20万元,在研,主持

3. 国家自然科学基金委员会,面上项目,31770184,EV71/CVA16衣壳蛋白VP0的裂解及其对感染性和疫苗免疫原性的影响,2018/01-2021/12,55万元,结题,参加

4. 国家自然科学基金委员会,面上项目,81771304,天然小分子化合物NAB01-10阻断视神经脊髓炎NMO-IgG与AQP4结合及神经保护作用的分子机制研究,2018/01-2021/12,54万元,结题,参加

5. 横向课题,常用蒙药的抗病毒活性研究,2018/01-2019/12,30万,结题,主持

6. 国家自然科学基金委员会,青年基金项目,31301179,水通道蛋白AQP8在卵泡发育中的作用和机制研究,2014/01-2016/12,26万元,结题,主持

7. 国家“十二五”科技重大专项子课题,2012ZX10001-009-002-03,重组流感疫苗生产工艺研究,2012/12-2015/12,40万元,结题,主持

8. 吉林省科技发展计划项目,青年基金,20140520001JH,两种天然产物单体抗EV71/CVA16的作用和机制研究,2014/01-2016/12,5万元,结题,主持


发表的论文


更新也可查阅连接

https://www.ncbi.nlm.nih.gov/pubmed/?term=weiheng+su


1. Xiao Yang, Mingming Wan, Linjun Cai, Ali Hou, Bo Sun, Yan Zhou, Feng Gao, Weiheng Su* and Chunlai Jiang*. Interferon Inhibition Enhances the Pilot-Scale Production of Rabies Virus in Human Diploid MRC-5 Cells. Viruses 2022, 14, 49.   


2. Hongtao Liu, Chunlai Jiang, Yu Wu, Min Wu, Jiaxin Wu, Guanshu Zhao, Jie Sun, Xinyu Huang, Jiemin Li, Rui Sheng, Julien Barbier, Jean-Christophe Cintrat, Daniel Gillet* and Weiheng Su*. Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy. International Journal of Molecular Sciences. 2022, 23, 3940.


3. Jie Liu, Junyang Lin, Linjun Cai, Jie Sun, Xue Ding, Cenrong Wang, Yanchun Wu, Xiaoling Gao, Weiheng Su*, Chunlai Jiang*. Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice. Viruses 2022,14,1214.


4. Yinghong Xiao, Peter Lidsky, Yuta Shirogane, Ranen Aviner, Chien-Ting Wu, Weiyi Li, Weihao Zheng, Dale Talbot, Adam Catching, Gilad Doitsh, Weiheng Su, Colby Gekko, Arabinda Nayak, Joel Ernst, Leonid Brodsky, Elia Brodsky, Elsa Rousseau, Sara Capponi, Simone Bianco, Robert Nakamura, Peter Jackson, Judith Frydman, Raul Andino*. A defective viral genome strategy elicits broad protective immunity against respiratory viruses. Cell 2021. 184, 1–15.


5. Yuta Shirogane, Elsa Rousseau, Jakub Voznica, Yinghong Xiao, Weiheng Su, Adam Catching, Zachary Whitfield, Igor Rouzine, Simone Bianco*, Raul Andino*. Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome. PLoS Pathogens 2021. 17(9): e1009277.


6. Jiaming Cao, Meng Qu, Hongtao Liu, Xuan Wan, Fang Li, Ali Hou, Yan Zhou, Bo Sun, Linjun Cai, Weiheng Su*, Chunlai Jiang*. Myristoylation of EV71 VP4 is Essential for Infectivity and Interaction with Membrane Structure, Virologica Sinica, 2020, 35(5):599-613.


7. Dai W, Bi J, Li F, Wang S, Huang X, Meng X, Sun B, Wang D, Kong W, Jiang C, Su Weiheng*. Antiviral Efficacy of Flavonoids against Enterovirus 71 Infection in Vitro and in Newborn Mice. Viruses. 2019 Jul 7;11(7). pii: E625.

8. Cao J, Liu H, Qu M, Hou A, Zhou Y, Sun B, Cai L, Gao F, Su Weiheng*, Jiang C. Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly. Microb Pathog. 2019 Sep; 134:103568.

9. Dai W, Wu Y, Bi J, Wang S, Li F, Kong W, Barbier J, Cintrat JC, Gao F, Gillet D*, Su W*, Jiang C*. Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. Viruses. 2018 Mar 9; 10(3).

10. Wang D, Di X, Wang J, Li M, Zhang D, Hou Y, Hu J, Zhang G, Zhang H, Sun M, Meng X, Sun B, Jiang C, Ma T, Su Weiheng*. Increased Formation of Follicular Antrum in Aquaporin-8-Deficient Mice Is Due to Defective Proliferation and Migration, and Not Steroidogenesis of Granulosa Cells. Front Physiol. 2018 Aug 23; 9:1193.

11. Shi W, Kou Y, Jiang H, Gao F, Kong W, Su W, Xu F, Jiang C. Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. Immunol Lett. 2018 Jun; 198:26-32.

12. Zhang D, Yang L, Su W, Zhao Y, Ma X, Zhou H, Xu B, Zhang K, Ma H. Aquaporin-4 Is Downregulated in the Basolateral Membrane of Ileum Epithelial Cells during Enterotoxigenic Escherichia coli-Induced Diarrhea in Mice. Front Microbiol. 2018 Jan 9; 8:2655.

13. Dai W, Wu Y, Bi J, Wang J, Wang S, Kong W, Barbier J, Cintrat JC, Gao F, Jiang Z, Gillet D*, Su W*, Jiang C*. Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro. J Microbiol Biotechnol. 2018 Jun 28;28(6):849-859.

14. Zhao D, Sun B, Sun S, Fu B, Liu C, Liu D, Chu Y, Ma Y, Bai L, Wu Y, Zhou Y, Su W, Hou A, Cai L, Xu F, Kong W, Jiang C. Characterization of human enterovirus71 virus-like particles used for vaccine antigens. PLoS One. 2017 Jul 21;12(7):e0181182.

15. Dai W, Wu Y, Bi J, Lu X, Hou A, Zhou Y, Sun B, Kong W, Barbier J, Cintrat JC, Gao F, Gillet D*, Su W*, Jiang C*. Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug; 144:311-321.

16. Su Weiheng, Li X, Chen M, Dai W, Sun S, Wang S, Sheng X, Sun S, Gao C, Hou A, Zhou Y, Sun B, Gao F, Xiao J, Zhang Z, Jiang C. Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015. Infect Genet Evol. 2017 Jun 14; 53:212-217.

17. Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge, Fang Liang, Xin Sheng, Wenwen Dai, Meili Chen, Jiayan Wu, Jingfa Xiao*, Weiheng Su*. Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells. BMC Genomics 2017, 18(Suppl 1):933.

18. Zhang D, Zhang K, Su Weiheng, Zhao Y, Ma X, Qian G, Qu G, Pei Z, Liu S, Ma H. Aquaporin-3 is down-regulated in jejunum villi epithelial cells during enterotoxigenic Escherichia coli-induced diarrhea in mice. Microb Pathog. 2017 Jun; 107:430-435.

19. Liu W, Zhou Y, Wang Z, Zhang Z, Wang Q, Su W, Chen Y, Zhang Y, Gao F, Jiang C, Kong W. Microbiol Immunol. Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. 2017 May; 61(5):176-184.

20. Wang D, Di X, Fu L, Li Y, Han X, Wu H, Cai L, Meng X, Jiang C, Kong W, Su Weiheng*. Analysis of serum β-amyloid peptides, α2-macroglobulin, complement factor H, and clusterin levels in APP/PS1 transgenic mice during progression of Alzheimer's disease. Neuroreport. 2016 Oct 19; 27(15):1114-9.

21. Su Weiheng, Gao J, Zang Y, Wu H, Wang L, Hu H, Yu X, Kong W, Jiang C. Production, characterization and immunogenicity of P particles derived from norovirus GII.4 genotype 2004 variant. Acta Virol. 2015; 59(1):33-39.

22. Fan P, Li X, Su Weiheng, Kong W, Kong X, Wang Z, Wang Y, Jiang C, Gao F. Enhanced Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked Fluorescence Oligonucleotide Assay. PLoS One. 2015 Apr 27; 10(4):e0125701. (SCI收录,IF 3.234)

23. Zang Y, Du D, Li N, Su Weiheng, Liu X, Zhang Y, Nie J, Wang Y, Kong W, Jiang C. Eliciting neutralizing antibodies against the membrane proximal external region of HIV-1 Env by chimeric live attenuated influenza A virus vaccines. Vaccine. 2015 Jun 28. pii: S0264-410X (15) 00873-7. (SCI收录,IF 3.624)

24. Fan P, Li X, Sun S, Su Weiheng, An D, Gao F, Kong W, Jiang C. Identification of a common epitope between enterovirus 71 and human MED25 proteins which may explain virus-associated neurological disease. Viruses. 2015 Mar 27; 7(4):1558-77. (SCI收录,IF 3.535)

25. Jiang L, Fan R, Sun S, Fan P, Su W, Zhou Y, Gao F, Xu F, Kong W, Jiang C. A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice. Vaccine. 2015 Nov 27; 33(48):6596-603.

26. Zhao D, Sun B, Jiang H, Sun S, Kong FT, Ma Y, Jiang L, Bai L, Chen X, Yang P, Liu C, Xu Y, Su Weiheng, Kong W, Xu F, Jiang C. Enterovirus71 virus-like particles produced from insect cells and purified by multistep chromatography elicit strong humoral immune responses in mice. J Appl Microbiol. 2015 Oct;119(4):1196-205.

27. Lin Xu#, Weiheng Su#, J Jin, JW Chen, XJ Li, XY Zhang, MY Sun, SY Sun, PH Fan, D An, HF Zhang, XG Zhang, W Kong, TH Ma, CL Jiang. Identification of Luteolin as Enterovirus 71 and Coxsackievirus A16 Inhibitors through Reporter Viruses and Cell Viability-Based Screening. Viruses. 2014, 6:2778-2795. (SCI收录,IF 3.353)

28. JW Chen, L Xu, SY Sun, HF Zhang, TH Ma, Weiheng Su*, CL Jiang*. Identification of Cinobufagin and Resibufogenin as Inhibitors of Enterovirus 71 Infection. Chem. Res. Chin. Univ. 2014, 30(6):953-958. (SCI收录,IF 1.119)

29. Sun M, Sui Y, Li L, Su Weiheng, Hao F, Zhu Q, Di W, Gao H, Ma T. Anoctamin 1 calcium-activated chloride channel downregulates estrogen production in mouse ovarian granulosa cells. Endocrinology. 2014 Aug; 155(8):2787-96. (SCI收录,IF 4.503)

30. Xiang Y, Liu W, Chen Y, Zhang C, Su Weiheng, Zhang Y, Sun J, Gao F, Jiang C. The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain. PLoS One. 2014 Jun 4;9(6):e98058. (SCI收录,IF 3.534)

31. Zang Y, Bi J, Du D, Liu X, Zhang Y, Su Weiheng, Wu J, Shan Y, Wang S, Kong W, Qiu A, Jiang C. Development of a Norovirus P particle platform for eliciting neutralizing antibody responses to the membrane proximal external region of human immunodeficiency virus type 1 envelope. Protein Pept Lett. 2014; 21(12):1230-9.

32. Zang Y, Du D, Ge P, Xu Y, Liu X, Zhang Y, Su Weiheng, Kiseleva I, Rudenko L, Xu F, Kong W, Jiang C. Development of one-step real-time PCR assay for titrating trivalent live attenuated influenza vaccines. Hum Vaccin Immunother. 2014; 10(12):3642-8. (SCI收录,IF 2.131)

33. Sun S, Jiang L, Liang Z, Mao Q, Su Weiheng, Zhang H, Li X, Jin J, Xu L, Zhao D, Fan P, An D, Yang P, Lu J, Lv X, Sun B, Xu F, Kong W, Jiang C. Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice. Hum Vaccin Immunother. 2014; 10(10):2885-2895. (SCI收录,IF 2.131)

34. Zhang H, An D, Liu W, Mao Q, Jin J, Xu L, Sun S, Jiang L, Li X, Shao J, Ma H, Huang X, Guo S, Chen H, Cheng T, Yang L, Su Weiheng, Kong W, Liang Z, Jiang C. Analysis of cross-reactive neutralizing antibodies in human HFMD serum with an EV71 pseudovirus-based assay. PLoS One. 2014; 9(6):e100545. (SCI收录,IF 3.534)

35. 陈嘉雯,徐琳,郜尧正,苏维恒*,陈维金*,蟾酥主要活性成分对EV71-EGFP病毒感染性克隆的抑制作用,中国新药杂志,2014,(16):1963-1966.

36. Su Weiheng, Guan X, Zhang D, Sun M, Yang L, Yi F, Hao F, Feng X, Ma T. Occurrence of multi-oocyte follicles in aquaporin 8-deficient mice. Reprod Biol Endocrinol. 2013 Sep 10; 11:88. (SCI收录,IF 2.144)

37. Xu H, Su Weiheng, Cai M, Jiang J, Zeng X, Wang H. The Asymmetrical Structure of Golgi Apparatus Membranes Revealed by In situ Atomic Force Microscope. PLoS One. 2013; 8(4):e61596. (SCI收录,IF 3.73)

38. Li X, Fan P, Jin J, Su Weiheng, An D, Xu L, Sun S, Zhang Y, Meng X, Gao F, Kong W, Jiang C. Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2. Virology Journal. 2013, 10:250. (SCI收录,IF 2.092)

39. 关新刚, 苏维恒, 郝峰, 张迪, 孙新. 视神经脊髓炎患者血清中的AQP4抗体检测. 中国实验诊断学. 2013. 17(12): 2170-2172.

40. Feng Hao, Fei Yi, Di Zhang, Yan Ning, Wei-heng Su, Xue-chao Feng, Hong Yang, Tong-hui Ma. Identification of herbal compound Imperatorin with adverse effects on ANO1 and CFTR chloride channels. Chem Res Chinese U. 2011, 27(3):410-412.

41. 乔颖, 刘津, 苏维恒, 冯学超, 何成彦. 水通道蛋白AQP1、 AQP3在神经鞘瘤中的表达. 中国实验诊断学. 2011 . 4(15): 607-608.

42. Weiheng Su, Ying Qiao, Fei Yi, Xingang Guan, Di Zhang, Shuzhi Zhang, Feng Hao, Yinghong Xiao, Hongguo Zhang, Lei Guo, Longfei Yang, Xuechao Feng Tonghui Ma. Increased Female Fertility in Aquaporin 8-deficient Mice. IUBMB Life. 2010, 62(11): 852–857. (SCI收录,IF 4.251)

43. Xin-gang Guan, Wei-heng Su, Fei Yi, Di Zhang, Feng Hao, Hong-Guo Zhang, Yue-Jiao Liu, Xue-Chao Feng, Tong-Hui Ma. NPA Motif Plays A Key Role In Membrane Targeting of Aquaporin 4. IUBMB Life. 2010, 62(3): 222-226. (SCI收录,IF 4.251)

44. Shuzhi Zhang, Yan Ji, Xiao Liu, Xiaodan Lu, Weiheng Su, Di Zhang, Feng Hao, Fei Yi, Lei Guo, Xiaomeng Li, Yaowu Zheng. Podocyte-speci?c VEGF Down-regulation and Pathophysiological Development. IUBMB Life. 2010, 62(9): 677-683. (SCI收录,IF 4.251)

45. Di Zhang, Lei Guo, Na Zhu, Wei-heng Su, Xin-gang Guan, Fei Yi, Feng Hao, Ying-hong Xiao, Jia Liu, Tian-zhou Liu, Tong-hui Ma. Aquaporin-3 Deletion Reduces Glycerol and ATP Content in Mouse Sciatic Nerve. Chem Res Chinese U. 2010, 26(6): 955-957.

46. Hong-guo Zhang, Ying-hong xiao, Long-fei Yang, Wei-heng Su, Xin-gang Guan, Yu Wang, Xue-Chao Feng, Tong-Hui Ma. Altered Taurine Release in the Hypothalamus of Aquaporin-4 Knockout Mice. Chem Res Chinese U. 2010, 26(3): 406-408.

47. 苏维恒.大鼠胚胎成纤维细胞的原代培养和分裂抑制. 内蒙古民族大学学报(自然科学版). 2009. 24(5): 523-525.

专利


1. 授权发明专利名称:Retro-2cycl及相关衍生物的用途。发明人:苏维恒,姜春来,代文文,丹尼尔·吉莱,让-克里斯托夫·桑塔,于廉·巴比尔,吴瑜。专利号:ZL 201710179425.7


2. 申请发明专利名称:木犀草素的新用途。发明人:苏维恒,姜春来,麻彤辉,徐琳。申请号201410270721.4。


3. 申请发明专利名称:华蟾酥毒基和酯蟾毒配基在抑制肠道病毒71型感染中的新用途。发明人:苏维恒,姜春来,陈嘉雯。申请号201410531039.6。


4. 授权专利名称:一种用于捣碎凝胶并收集DNA溶液的装置。发明人:苏维恒. 专利号:ZL 200920093543.7.


5. 授权专利名称:连接反应保温盒。发明人:苏维恒. 专利号:ZL 200920093542.2.

会议做学术报告

1. 苏维恒;化合物ABMADABMA广谱抑制呼吸道病毒(新型冠状病毒与流感病毒)感染的作用与机制研究,第十四届全国病毒学学术研讨会暨第九届武汉现代病毒学国际研讨会,中国,武汉市,2021-09-262021-09-28.

2. 苏维恒;黄酮类化合物在体外和体内抑制肠道病毒71型感染的研究,中华医学会医学病毒学分会“第六届全国病毒感染与器官功能衰竭学术会议”暨“新突发与重症病毒感染临床护理论坛”,中国,重庆市,2019-03-292019-03-31.