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生物工程系

李全顺

日期:2020-08-11 点击数: 来源:

姓名:李全顺

工作地点:

生命科学楼236

工作经历:

2010.012012.09 吉林大学分子酶学工程教育部重点实验室 讲师

2012.092015.09 吉林大学分子酶学工程教育部重点实验室 副教授

2015.09—至今 吉林大学分子酶学工程教育部重点实验室 教授、博士生导师

2016.032017.03 美国塔夫斯大学生物医学工程系 访问学者

2016.072019.12 吉林大学分子酶学工程教育部重点实验室 副主任

2019.12—至今 吉林大学分子酶学工程教育部重点实验室 主任

2020.12—至今 吉林大学生命科学学院  副院长


荣誉称号:

学术兼职:

中国生物化学与分子生物学会酶学分会 委员

中国生物物理学会材料生物学与智能诊疗技术分会 委员

中国生物物理学会纳米酶分会  委员

中国细胞生物学会青年专业委员会 委员

吉林省生物物理学会 常务理事

吉林省生物化学与分子生物学会 理事

吉林大学青年科技工作者协会 理事

吉林大学生命科学学院学术委员会 委员

吉林大学生命科学学院学位委员会 副主任

吉林大学理学部学位委员会 委员

Bioresources and Bioprocessing杂志  青年编委

吉林大学学报(理学版) 编委

荣誉奖励:

2014年,吉林大学教书育人先进个人称号

2015年,第十四届“挑战杯”全国大学生课外学术科技作品竞赛优秀指导教师奖

2017年,吉林大学唐敖庆青年人才奖

2017年,吉林省“挑战杯”大学生课外学术科技作品竞赛优秀指导教师奖

2019年,中国微生物学会新华扬优秀青年酶工程学家奖

2021年,入选吉林省首批长白山青年人才工程支持

2021年,入选吉林大学唐敖庆英才教授支持


研究成果:

承担项目(均为项目负责人):

[1] 基于酶和工程菌改造技术的分布式DNA活字存储阵列研究,国家重点研发计划项目,202011月——202510月。

[2] 骨植入器械表面微纳结构和高结合强度骨诱导涂层的可控构筑,国家重点研发计划项目子课题,20189月——20216月。

[3] 酶促化学偶联合成多羟基聚氨酯材料及介导颗粒酶B递送的研究,国家自然科学基金面上项目,20211月——202412月。

[4] 外泌体介导miR-23b分选拮抗Infliximab治疗类风湿性关节炎的调控机制探索,国家自然科学基金面上项目,20191月——202212月。

[5] 基于皮肤代谢和信号通路分析探究多柔比星脂质体诱发HFS不良反应的作用机制,国家自然科学基金面上项目,20171月——202012月。

[6] 具有双重精准识别功能的单抗靶向型脱氧核酶传输体系的构建与评价,国家自然科学基金面上项目,20141月——201712月。

[7] 具有双组分协同效应的重组嗜热组蛋白-PEI衍生物杂合基因传输系统的构建与评价,国家自然科学基金青年基金,20131月——201512月。

[8] 多肽靶向抗肿瘤药物高分子载体的研究与开发,国家科技部国际科技合作专项项目子课题,20121月——201412月。

[9] 新型卤代烷脱卤酶的开发与分子改造研究,教育部博士学科点专项科研基金,20121月——201412月。

[10] 工程及仿生酶催化构建生物医用高分子材料的研究。吉林省省校共建计划专项,20179月——20208月。

[11] 生物催化构建医用高分子材料的研究,吉林省发展和改革委员会产业技术研究与开发,20211月——202212月。

[12] 白僵菌纳米剂型创制及防控玉米螟研究,吉林省科技厅自然科学基金项目,20191月——202112月。

[13] 具有双重精准识别功能的单抗靶向型脱氧核酶传输体系的构建与评价,吉林省科技厅自然科学基金项目,20141月——201612月。

[14] 具有双组分协同效应的重组嗜热组蛋白-PEI杂合基因传输系统的构建与评价,吉林省科技厅青年科研基金项目,20131月——201512月。

[15] 重组嗜热组蛋白-PEN杂合基因传输体系的构建与评价,吉林省教育厅“十三五”科学技术项目,20191月——202012月。

[16] 肿瘤靶向脱氧核酶递释体系的构建,吉林省教育厅“十二五”科学技术项目,20157月——20176月。

[17] 酶促化学偶联构建聚酯-g-PEI基因传输载体的研究,吉林省高校优秀青年科研人才春苗培育计划,20134月——20154月。


发表论文(2016年至今,均为通讯作者):

1. Huihui Qu, Cong Wang, Yixuan Guo, Ziying Zhao, Long Qiao, Jiebing Yang, Haixia Wu*, Quanshun Li*, Alideertu Dong*. Electrospun N-halamine/ ZnO-based platform eradicates bacteria through multimodal antimicrobial mechanism of action. Rare Metals 2022, accepted.

2. Simeng Wei, Xinxin Shao, Yong Liu, Boyu Xiong, Pengfei Cui, Ziling Liu*, Quanshun Li*. Genome editing of PD-L1 mediated by nucleobase-modified polyamidoamine for cancer immunotherapy. J. Mater. Chem. B 2022, 10: 1291-1300.

3. Tianyou Qin*, Jiaqi Han, Lan Sheng*, Quanshun Li*, Sean Xiao-An Zhang. Optically-manipulated multiaddressable all-ESIPT fluorescence nanomicelles prepared with a single fluorophore. J. Mater. Chem. C 2022, 10: 840-845.

4. Tianyou Qin*, Jiaqi Han, Lan Sheng*, Quanshun Li*, Sean Xiao-An Zhang. Optically-manipulated multiaddressable all-ESIPT fluorescence nanomicelles prepared with a single fluorophore. J. Mater. Chem. C 2021, accepted.

5. Gu Gong, Xiuhui Tang, Jiayuan Zhang, Xiao Liang, Jiebing Yang*, Quanshun Li*. Phenylboronic acid-modified polyamidoamine-mediated the transfection of Polo-like kinase-1 siRNA to achieve an anti-tumor efficacy. Int. J. Nanomed. 2021, 16: 8037-8048.

6. Xiao Liang, Yingxuan Chen, Kai Wen, Haobo Han*, Quanshun Li*. Urate oxidase-loaded in PCN-222(Fe) with peroxidase-like activity for colorimetric detection of uric acid. J. Mater. Chem. B 2021, 9: 6811-6817.

7. Xiao Liang, Yong Liu, Kai Wen, Wei Jiang*, Quanshun Li*. Immobilized enzymes in inorganic hybrid nanoflowers for biocatalytic and biosensing applications. J. Mater. Chem. B 2021, 9: 7597-7607.

8. Yu Huang, Longxiang Wang, Yingxuan Chen, Haobo Han*, Quanshun Li*. Lipoic acid-modified oligoethyleneimine-mediated miR-34a delivery to achieve the anti-tumor efficacy. Molecules 2021, 26: 4827.

9. Xiuhui Tang, Xiao Liang, Kai Wen, Yingxuan Chen, Haobo Han*, Quanshun Li*. Dual ATP/reduction-responsive polyplex to achieve the co-delivery of doxorubicin and miR-23b for the cancer treatment. Colloids Surf. B: Biointerfaces 2021, 206: 111955.

10. Boyu Xiong, Yanxu Chen, Yong Liu, Xiaolin Hu, Haobo Han*, Quanshun Li*. Artesunate-loaded porous PLGA microsphere as a pulmonary delivery system for the treatment of non-small cell lung cancer. Colloids Surf. B: Biointerfaces 2021, 206: 111937.

11. Xiao Liang, Yudi Wang, Hui Shi, Mengmeng Dong, Haobo Han*, Quanshun Li*. Nucleolin-targeting AS1411 aptamer-modified micelle for the co-delivery of doxorubicin and miR-519c to improve the therapeutic efficacy in hepatocellular carcinoma treatment. Int. J. Nanomed. 2021, 16: 2569-2584.

12. Sihan Wang, Jiakai Xing, Boyu Xiong, Haobo Han, Min Hu*, Quanshun Li*. Fluoropolymer-mediated intracellular delivery of miR-23b for the osteocyte differentiation in osteoblasts. Macromol. Biosci. 2021, e2100024.

13. Xiaolin Hu, Mengmeng Dong, Xiao Liang, Ziling Liu*, Quanshun Li*. Reactive oxygen species-mediated inflammation and apoptosis in hand-foot syndrome induced by PEGylated liposomal doxorubicin. Int. J. Nanomed. 2021, 16: 471-480.

14. Jiakai Xing, Jiaxin Jia, Xiaofeng Cong, Ziling Liu*, Quanshun Li*. N-Isopropylacrylamide-modified polyethylenimine-mediated miR-29a delivery to inhibit the proliferation and migration of lung cancer cells. Colloids Surf. B: Biointerfaces 2021, 198: 111463.

15. Yong Liu, Xinxin Shao, Deqiang Kong, Guangquan Li*, Quanshun Li*. Immobilization of thermophilic lipase in inorganic hybrid nanoflower through biomimetic mineralization. Colloids Surf. B: Biointerfaces 2021, 197: 111450.

16. Xiao Liang, Qing Li, Zhiyuan Shi, Shaowei Bai, Quanshun Li*. Immobilization of urease in metal-organic frameworks via biomimetic mineralization and its application in urea degradation. Chinese J. Chem. Eng. 2020, 28: 2173-2180.

17. Qing Li, Yingxuan Chen, Shaowei Bai, Xinxin Shao, Lin Jiang, Quanshun Li*. Immobilized lipase in bio-based metal-organic frameworks constructed by biomimetic mineralization: a sustainable biocatalyst for biodiesel synthesis. Colloids Surf. B: Biointerfaces 2020, 188: 110812.

18. Haobo Han, Jiebing Yang, Wenqi Chen, Qing Li, Yan Yang*, Quanshun Li*. A comprehensive review on histone-mediated transfection for gene therapy. Biotechnol. Adv. 2019, 37: 132-144.

19. Zheyu Song, Xiao Liang, Yudi Wang, Haobo Han, Jiebing Yang, Xeudong Fang*, Quanshun Li*. Phenylboronic acid-functionalized polyamidoamine-mediated miR-34a delivery for the treatment of gastric cancer. Biomater. Sci. 2019, 7: 1632-1642.

20. Jiebing Yang, Jiayuan Zhang, Yong Liu, Zhiyuan Shi, Haobo Han*, Quanshun Li*. Phenylboronic acid-modified polyamidoamine-mediated delivery of short GC rich DNA for hepatocarcinoma gene therapy. Biomater. Sci. 2019, 7: 3348-3358.

21. Qinggele Borjihan, Jiebing Yang, Qing Song, Lingling Gao, Miao Xu, Tianyi Gao, Wenxin Liu, Peng Li*, Quanshun Li*, Alideertu Dong*. Povidone-iodine- functionalized fluorinated copolymers with dual-functional antibacterial and antifouling activities. Biomater. Sci. 2019, 7: 3334-3347.

22. Mengmeng Dong, Jiawen Chen, Jiayuan Zhang, Xiao Liang, Jiebing Yang, Dan Li*, Quanshun Li*. A chemoenzymatically synthesized cholesterol- g-poly(amine-co-ester)-mediated p53 gene delivery for achieving antitumor efficacy in prostate cancer. Int. J. Nanomed. 2019, 14: 1149-1161.

23. Tianyi Gao, Qinggele Borjihan, Jiebing Yang, Huihui Qu, Wenxin Liu, Quanshun Li*, Yanjie Wang*, Alideertu Dong*. Antibacterial povidone-iodine -conjugated cross-linked polystyrene resin for water bacterial decontamination. ACS Appl. Bio Mater. 2019, 2: 1310-1321.

24. Jiebing Yang, Jiayuan Zhang, Jiakai Xing, Zhiyuan Shi, Haobo Han*, Quanshun Li*. Inhibition of proliferation and migration of tumor cells through phenylboronic acid-functionalized polyamidoamine-mediated delivery of a therapeutic DNAzyme Dz13. Int. J. Nanomed. 2019, 14: 6371-6385.

25. Xiao Liang, Xiuhui Tang, Jiebing Yang, Jiayuan Zhang, Haobo Han*, Quanshun Li*. A genipin-crosslinked protein-polymer hybrid system for the intracellular delivery of ribonuclease A. Int. J. Nanomed. 2019, 14: 7389-7398.

26. Jiaxin Jia, Shudi Zhang, Kai Wen, Quanshun Li*. Nano-scaled zeolitic imidazole framework-8 as an efficient carrier for the intracellular delivery of RNase A in cancer treatment. Int. J. Nanomed. 2019, 14: 9971-9981.

27. Xiuhui Tang, Qing Li, Xiao Liang, Jiebing Yang, Ziling Liu*, Quanshun Li*. Inhibition of proliferation and migration of tumor cells through lipoic acid-modified oligoethylenimine-mediated p53 gene delivery. New J. Chem. 2019, 43: 2758-2765.

28. Yong Liu, Xinxin Shao, Zhiyuan Shi, Quanshun Li*. Inhibition of cancer cell proliferation by adenosine triphosphate-triggered codelivery system of p53 gene and doxorubicin. Cancer+ 2019, 1: 1-9.

29. Wei Jiang, Jiebing Yang, Xinghuo Wang, Haobo Han, Yan Yang, Jun Tang, Quanshun Li*. Phenol degradation catalyzed by a peroxidase mimic constructed through the grafting of heme onto metal-organic frameworks. Bioresource Technol. 2018, 247: 1246-1248.

30. Wei Jiang, Xinghuo Wang, Jiebing Yang, Haobo Han, Quanshun Li*, Jun Tang*. Lipase-inorganic hybrid nanoflower constructed through biomimetic mineralization: a new support for biodiesel synthesis. J. Colloid Interface Sci. 2018, 514: 102-107.

31. Wei Jiang, Yue Pan, Jiebing Yang, Yong Liu, Yan Yang, Jun Tang*, Quanshun Li*. A peroxidase mimic with atom transfer radical polymerization activity constructed through the grafting of heme onto metal-organic frameworks. J. Colloid Interface Sci. 2018, 521: 62-68.

32. Jiebing Yang, Yong Liu, Xiao Liang, Yan Yang*, Quanshun Li*. Enantio-, regio-, and chemoselective lipase-catalyzed polymer synthesis. Macromol. Biosci. 2018, 18: 1800131.

33. Haobo Han, Wenqi Chen, Jiebing Yang, Jiayuan Zhang, Quanshun Li*, Yan Yang*. 2-Amino-6-chloropurine-modified polyamidoamine-mediated p53 gene transfection to achieve anti-tumor efficacy. New J. Chem. 2018, 42: 13375-13381.

34. Mengmeng Dong, Jiawen Chen, Jiebing Yang, Wei Jiang, Haobo Han, Quanshun Li*, Yan Yang*. Chemoenzymatic synthesis of a cholesterol-g-poly(amine-co- ester) carrier for p53 gene delivery to inhibit the proliferation and migration of tumor cells. New J. Chem. 2018, 42: 13541-13548.

35. Wei Jiang, Xinghuo Wang, Jiawen Chen, Ying Lu, Haobo Han, Yi Ding, Quanshun Li*, Jun Tang*. Deuterohemin-peptide enzyme mimic-embedded metal-organic frameworks through biomimetic mineralization with efficient ATRP catalytic activity. ACS Appl. Mater. Interfaces 2017, 9: 16948-16957.

36. Wenqi Chen, Yong Liu, Xiao Liang, Yu Huang, Quanshun Li*. Chondroitin sulfate-functionalized polyamidoamine as a tumor-targeted carrier for miR-34a delivery. Acta Biomater. 2017, 57: 238-250.

37. Jiawen Chen, Wei Jiang, Haobo Han, Jiebing Yang, Wenqi Chen, Yudi Wang, Jun Tang*, Quanshun Li*. Chemoenzymatic synthesis of cholesterol-g-poly (amine-co-ester) amphiphilic copolymer as a carrier for miR-23b delivery. ACS Macro Lett. 2017, 6: 523-528.

38. Yudi Wang, Jiawen Chen, Xiao Liang, Haobo Han, Hao Wang, Yan Yang*, Quanshun Li*. An ATP-responsive codelivery system of doxorubicin and miR-34a to synergistically inhibit cell proliferation and migration. Mol. Pharmaceutics 2017, 14: 2323-2332.

39. Jianxu Zhang, Yudi Wang, Jiawen Chen, Xiao Liang, Haobo Han, Yan Yang, Quanshun Li*, Yanbo Wang*. Inhibition of cell proliferation through an ATP-responsive co-delivery system of doxorubicin and Bcl-2 siRNA. Int. J. Nanomed. 2017, 12: 4721-4732.

40. Haobo Han, Jiebing Yang, Yudi Wang, Wenqi Chen, Jiawen Chen, Yan Yang*, Quanshun Li*. Nucleobase-modified polyamidoamine-mediated miR-23b delivery to inhibit the proliferation and migration of lung cancer. Biomater. Sci. 2017, 5: 2268-2275.

41. Chenhui Wang, Jiebing Yang, Haobo Han, Jiawen Chen, Yudi Wang, Quanshun Li*, Yanbo Wang*. Disulfiram-loaded porous PLGA microparticle for inhibiting the proliferation and migration of non-small-cell lung cancer. Int. J. Nanomed. 2017, 12: 827-837.

42. Chenhui Wang, Haobo Han, Wei Jiang, Xiaobo Ding, Quanshun Li*, Yanbo Wang*. Immobilization of thermostable lipase QLM on core-shell structured polydopamine-coated Fe3O4 nanoparticles. Catalysts 2017, 7: 49.

43. Hongming He, Haobo Han, Hui Shi, Yuyang Tian, Fuxing Sun, Yang Song, Quanshun Li*, Guangshan Zhu*. Construction of thermophilic lipase-embedded metal-organic frameworks via biomimetic mineralization: a biocatalyst for ester hydrolysis and kinetic resolution. ACS Appl. Mater. Interfaces 2016, 8: 24517-24524.

44. Di Wu, Chenhui Wang, Jiebing Yang, Hao Wang, Haobo Han, Aijun Zhang, Yan Yang*, Quanshun Li*. Improving the intracellular drug concentration in lung cancer treatment through the codelivery of doxorubicin and miR-519c mediated by porous PLGA microparticle. Mol. Pharmaceutics 2016, 13: 3925-3933.

45. Di Wu, Jiebing Yang, Zhen Xing, Haobo Han, Tingting Wang, Aijun Zhang, Yan Yang*, Quanshun Li*. Phenylboronic acid-functionalized polyamidoamine- mediated Bcl-2 siRNA delivery for inhibiting the cell proliferation. Colloids Surf. B: Biointerfaces 2016, 146: 318-325.

46. Yan Duan, Zhen Xing, Jiebing Yang, Yudi Wang, Jiawen Chen, Yan Zhang, Wei Shi*, Quanshun Li*. Chondroitin sulfate-functionalized polyamidoamine- mediated miR-34a delivery for inhibiting the proliferation and migration of pancreatic cancer. RSC Adv. 2016, 6: 70870-70876.

47. Di Wu, Hanbo Han, Zhen Xing, Jianxu Zhang, Li Li, Wei Shi*, Quanshun Li*. Ideal and reality: barricade in the delivery of small interfering RNA for cancer therapy. Curr. Pharm. Biotechnol. 2016, 17: 237-247.

48. Hui Ren, Zhen Xing, Jiebing Yang, Wei Jiang, Gang Zhang*, Jun Tang*, Quanshun Li*. Construction of an immobilized thermophilic esterase on epoxy support for poly(ε-caprolactone) synthesis. Molecules 2016, 21: E796.

获得专利

1. 李全顺,兴振,王旭,杨洁冰,杨艳,施维。一种靶向SALL4基因的脱氧核酶分子及在乳腺癌基因治疗中的应用。专利授权号:ZL 201610383360.3.

2. 李全顺,史植元,路杨,张正坤,李启云,隋丽,杜茜,赵宇。球孢白僵菌孢子-杂化纳米花生物农药、制备方法及应用。专利授权号:ZL 202110563648.X.

3. 李全顺,邵新欣,李青,刘勇,梁骁。一种具有抗衰老作用的外泌体-超氧化物歧化酶纳米制剂及其制备方法。专利授权号:ZL 201910593342.1.

4. 李全顺,梁骁,温凯,姜伟,陈英韩浩博一种多羟基聚氨酯蛋白质转染试剂、制备方法及其应用。专利授权号:ZL 202110900359.4.