近年来主持省部级以上课题23项,其中国家自然科学基金项目6项,其中教育部“新世纪优秀人才”支持计划、吉林省中青年科技创新领军人才及优秀团队项目、吉林省杰出青年基金项目等人才计划项目4项,已授权发明专利6项和受理发明专利6项,以第一作者或通讯作者在Hepatology,J Hepatol,Cell Res,Chem Eng J,Biosens Bioelectron等学术刊物上发表文章50余篇,参与撰写专著1部。以第一完成人身份完成的科研成果荣获“吉林省自然科学奖”二等奖1项、吉林省自然科学学成果奖一等奖1项、吉林省自然科学学成果奖二等奖1项、吉林省科学技术进步奖三等奖1项等多项奖励。 近期主持的主要纵向科研项目: 1. 保护药物性肝损伤的靶向PHD2新型重组抗体的制备及其作用机制研究, 吉林省自然科学基金(省地联合基金—长春创新发展联合基金)项目,2025.01 - 2027.12, 主持 2. 巨噬细胞TRIM59在急性药物性肝损伤中的作用及机制研究,国家自然科学基金面上项目,2023.01-2026.12,主持 3. 保护药物性肝损伤的稀有人参皂苷群的研发,吉林省科技发展计划重点研发项目,2022.07-2025.06,主持 4. 靶向PHD2胞内抗体介导的肝损伤保护作用的分子机制,吉林省自然科学基金项目,2021.07–2024.06,主持 5. 中国科学院-威高研究发展计划攻关项目,2020.06–2023.06,主持 6. 肿瘤靶向抗CDK4胞内抗体抑制肿瘤转移的作用效能及分子调控机制,国家自然科学基金面上项目,2016.01-2019.12,主持 近期代表性文章: 1. Small extracellular vesicles detection by dielectrophoresis-based microfluidic chip filled with transparent antibody-conjugated microbeads for breast cancer diagnosis. Anal Chem, 2025, 97(10):5678-5687. doi: 10.1021/acs.analchem.4c06592. 2. Immunofluorescent analysis of exosomes using a microchip filled with transparent antibody-conjugated beads for breast cancer liquid biopsy. Anal Chim Acta, 2025, 1345:343743. doi: 10.1016/j.aca.2025.343743. 3. Small extracellular vesicles detection using dielectrophoresis-based microfluidic chip for diagnosis of breast cancer. Biosens Bioelectron, 2024, 259: 116382. doi: 10.1016/j.bios.2024.116382. 4. Controlled synthesis of metal-organic frameworks via AC electrokinetic mixing-assisted microfluidics: A case study of ZIF-8. Chem Eng J, 2024, 480: 148208. DOI: 10.1016/j.cej.2023.148208. 5. The regulation of exosome generation and function in physiological and pathological processes. Int J Mol Sci, 2024, 25(1): 225. DOI: 10.3390/ijms25010255. 6. The role of TRIM family in metabolic associated fatty liver disease. Front Endocrinol, 2023, 14: 1210330. DOI: 10.3389/fendo.2023.1210330. 7. A specific anti-cyclin D1 intrabody represses breast cancer cell proliferation by interrupting the cyclin D1–CDK4 interaction. Breast Cancer Res Treat, 2023, 198(3): 555-568. doi: 10.1007/s10549-023-06866-7. 8. Immunofluorescence analysis of breast cancer biomarkers using antibody-conjugated microbeads embedded in a microfluidic-based liquid biopsy chip. Biosens Bioelectron, 2022, 216: 114598. DOI: 10.1016/j.bios.2022.114598. 9. Clot structure-based physical-matching design of platelet cloaking nano-delivery system facilitates specific arteriovenous thrombolysis. Chem Eng J, 2022, 441: 135982. https://doi.org/10.1016/j.cej.2022.135982 10. The Role of Exosomes in Inflammatory Diseases and Tumor-Related Inflammation. Cells, 2022, 11(6):1005. doi: 10.3390/cells11061005. 11. Expression, purification and characterisation of a human anti-CDK4 single-chain variable fragment antibody. BMC Biotechnol, 2021,21(1):71. doi: 10.1186/s12896-021-00729-z. 12. Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis. Biomed Pharmacother, 2020, 123: 109783. doi: 10.1016/j.biopha.2019.109783. 13. Cancer liquid biopsy using integrated microfluidic exosome analysis platforms. Biotechnol J, 2020, 15(5):1900225.doi: 10.1002/biot.201900225. 14. Separation of macrophages using a dielectrophoresis-based microfluidic device. BioChip J , 2020, 14(2): 185–194. doi: 10.1007/s13206-020-4207-2 15. A cyclin D1-specific single-chain variable fragment antibody that inhibits HepG2 cell growth and proliferation. Biotechnol J, 2020, 15(8):1900430. doi: 10.1002/biot.201900430. 16. Explore a novel function of human condensins in cellular senescence. Cell Biosci, 2020, 10(1):147. doi: 10.1186/s13578-020-00512-1. 17. Extraction of cell-free whole blood plasma using a dielectrophoresis - based microfluidic device. Biotechnol J, 2019, 14(3): 1800181. doi: 10.1002/biot.201800181. 18. Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α. Sci Rep, 2019, 9(1): 11861. doi: 10.1038/s41598-019-47891-1. 19. TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1. Aging (Albany NY), 2019, 11(19): 8623-8641. doi: 10.18632/aging.102351 20. TRIM59: A membrane protein expressed on Bacillus Calmette-Guérin-activated macrophages that induces apoptosis of fibrosarcoma cells by direct contact. Exp Cell Res, 2019, 384(1): 111590. doi: 10.1016/j.yexcr.2019.111590. 21. Subunits of human condensins are potential therapeutic targets for cancers. Cell Div, 2018, 13: 2. doi: 10.1186/s13008-018-0035-3. 22. Effects of metal ions on the structure and activity of a human anti-cyclin D1 single-chain variable fragment AD5. Mol Med Rep, 2017, 16(2): 1314-1320.doi: 10.3892/mmr.2017.6756. 23. Prokaryotic expression, purification and characterization of human cyclooxygenase-2. Int J Mol Med, 2017, 40(1): 75-82. doi: 10.3892/ijmm.2017.3007. 24. Exosome separation using microfluidic systems: size-based, immunoaffinity-based and dynamic methodologies. Biotechnol J, 2017, 12(4): 1600699. doi: 10.1002/biot.201600699 25. Role of gp91phox in hepatic macrophage programming and alcoholic liver disease. Hepatol Commun, 2017, 1(8): 765-779. doi: 10.1002/hep4.1078. 主要科研获奖: 1. 组织损伤及修复的免疫学调控及机制研究, 吉林省科学技术奖-自然科学奖,二等奖,2018, 第一完成人. 2. 人集缩素亚基是癌症治疗的潜在靶点, 吉林省科学技术奖-自然科学奖,三等奖,2022,第二完成人. 3. 胞浆型磷脂酶A2α保护Fas诱导的但不保护LPS诱导的肝损伤, 吉林省自然科学学术成果奖,二等奖,2014, 第一完成人. 4. Cyclooxygenase-2 Prevents Fas-Induced Liver Injury Through Up-Regulation of Epidermal Growth Factor Receptor, 吉林省自然科学学术成果奖,一等奖,2011, 第一完成人. 5. 肿瘤细胞特异性的重组CDI真核表达载体的构建及其在肿瘤治疗中的应用,吉林省科技进步奖,三等奖,2008, 第一完成人. 专著: 参与编写《合成生物学与合成酶学》(“十二五”国家重点图书出版规划项目), 科学出版社, 2012年4月出版. 授权发明专利: 1. 一种人源单链抗体及其应用,中国,发明专利,ZL 201711449190.5 2. 一种内置透明电极的全透明微流控芯片及其制备方法, 中国,发明专利,ZL 201710644638.2 3. 一种实现全血血浆持续分离的微流控器件及其分离方法, 中国,发明专利,ZL 201710644637.8 4. 一种抗肿瘤人源单链抗体,中国,发明专利,ZL 201010104607.6 5. 一种肿瘤细胞特异性真核表达载体,中国,发明专利,ZL 200410011191.8 6. 一种检测大肠杆菌的微流控芯片、微流控装置及检测方法,中国,发明专利,ZL 202111059635.5 |