XIANG Hongyu
post: 2013-06-21 14:25  view:1460


 XIANG Hongyu, Ph.D.

Associate Professors,  School of Life Science, Jilin University

email: hyxiang@jlu.edu.cn



Life Science Building, Jilin University, Qianjin Street No.2699,Changchun,P. R. China,

Postal code:130012

Research Interests

 1. Protein engineering and biomedicine
 ► Prevention, diagnosis and therapy of atherosclerosis targeting lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)
 ►Molecular design and screening of new nucleic acid aptamer for anti-plant viral activities

2. Resource microbiology and molecular microbial ecology
 ►Fermentation system of Massa Medicata Fermentata, a traditional Chinese medicine, and its applications
 ►Fermentation system of Douchi, a traditional Chinese food, and the development of performance enhancement of soybean product
 ►The key bioremediation technology of Yitong River in Changchun, China
 ► Causes and regulations of Succession cropping obstacle of Panax Ginseng C. A. Mey

3. Applied Microbiology and Biotechnology
 ► The in-depth development of microbial enzymes and their application to new fields
 ►Construction and application of modern complex microbial fermentation system


Representative papers

1. Xu Y, Xie YB, Zhang XR, Chen C, Xiang H*, Xie Q*. Monitoring of the bacterial and fungal biodiversity and dynamics during Massa Medicata Fermentata fermentation. Appl Microbiol Biotechnol (accepted)

2. Mu T, Liang W, Ju Y, Wang Z, Wang Z, Roycik M, Sang QX, Yu D, Xiang H*, Fang X*. Efficient soluble expression of secreted Matrix Metalloproteinase 26 in Brevibacillus choshinensis. Protein Expr Purif  (accepted)

3. Liu Y, Li QS, Zhu HL, Meng ZL, Xiang H*, Xie Q. Purification and characterization of two thermostable glucoamylases produced by Aspergillus niger B-30. Chem. Res. Chinese Universities (accepted)

4. Nishikiori M, Sugiyama S, Xiang H, Niiyama M, Ishibashi K, Inoue T, Ishikawa M, Matsumura H, Katoh E. Crystal structure of the superfamily 1 helicase from Tomato mosaic virus. J Virol. 2012 Jul; 86(14):7565-76.

5. Xiang H, Ishibashi K, Nishikiori M, Jaudal MC, Ishikawa M, Katoh E. Expression, purification, and functional characterization of a stable helicase domain from a tomato mosaic virus replication protein. Protein Expr Purif. 2012 Jan; 81(1):89-95.

6. Xiang H, Niiyama M, Sugiyama S, Adachi H, Takano K, Murakami S, Inoue T, Mori Y, Ishikawa M, Matsumura H, Katoh E. Crystallization and preliminary X-ray crystallographic analysis of a helicase-like domain from a tomato mosaic virus replication protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1; 67(Pt 12):1649-52.

7. Okamura H, Nishikiori M, Xiang H, Ishikawa M, Katoh E. Interconversion of two GDP-bound conformations and their selection in an Arf-family small G protein.Structure. 2011 Jul 13; 19(7):988-98.

8. Xiang H, Takeuchi H, Tsunoda Y, Nakajima M, Murata K, Ueguchi-Tanaka M, Kidokoro S, Kezuka Y, Nonaka T, Matsuoka M, Katoh E. Thermodynamic characterization of OsGID1-gibberellin binding using calorimetry and docking simulations. J Mol Recognit. 2011 Mar-Apr; 24(2):275-82.

9. Shiba K, Niidome T, Katoh E, Xiang H, Han L, Mori T, Katayama Y. Polydispersity as a parameter for indicating the thermal stability of proteins by dynamic light scattering. Anal Sci. 2010; 26(6):659-63.

10. Hirano K, Nakajima M, Asano K, Nishiyama T, Sakakibara H, Kojima M, Katoh E, Xiang H, Tanahashi T, Hasebe M, Banks JA, Ashikari M, Kitano H, Ueguchi-Tanaka M, Matsuoka M. The GID1-mediated gibberellin perception mechanism is conserved in the Lycophyte Selaginella moellendorffii but not in the Bryophyte Physcomitrella patens. Plant Cell. 2007 Oct; 19(10):3058-79.

11. Ueguchi-Tanaka M, Nakajima M, Katoh E, Ohmiya H, Asano K, Saji S, Xiang H, Ashikari M, Kitano H, Yamaguchi I, Matsuoka M. Molecular interactions of a soluble gibberellin receptor, GID1, with a rice DELLA protein, SLR1, and gibberellin. Plant Cell. 2007 Jul; 19(7):2140-55.

12. Xiang H, Masuo S, Hoshino T, Takaya N. Novel family of cholesterol esterases produced by actinomycetes bacteria. Biochim Biophys Acta. 2007 Jan; 1774(1):112-20.

13. Xiang H, Takaya N, Hoshino T. Novel cholesterol esterase secreted by Streptomyces persists during aqueous long-term storage. J Biosci Bioeng. 2006 Jan; 101(1):19-25.



College of Life Sciences, Jilin University,Changchun,China,130012

Tel:+86-431-81969061  Email: smxyld@jlu.edu.cn