XIE Qiuhong


XIE Qiuhong PH.D.

Professor,Shool of Life Sciences, Jilin University

Email: qhxie@jlu.edu.cn



Life Science Building, Jilin University, Qianjin Street No.2699,Changchun,P. R. China,

Postal Code: 130012

Research Interests

 1. Protein engineering and biomedicine
    ♦  Prevention, diagnosis and therapy of atherosclerosis targeting lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)
   ♦   Molecular design and screening of new nucleic acid aptamer for anti-plant viral activities

2. Resource microbiology and molecular microbial ecology
   ♦  Fermentation system of Massa Medicata Fermentata, a traditional Chinese medicine, and its applications
   ♦  Fermentation system of Douchi, a traditional Chinese food, and the development of performance enhancement of soybean product
   ♦  The key bioremediation technology of Yitong River in Changchun, China
   ♦  Causes and regulations of Succession cropping obstacle of Panax Ginseng C. A. Mey
3. Applied Microbiology and Biotechnology
   ♦  The in-depth development of microbial enzymes and their application to new fields
   ♦  Construction and application of modern complex microbial fermentation system

Representative papers

1. Xu Y, Xie YB, Zhang XR, Chen C, Xiang H*, Xie Q*. Monitoring of the bacterial and fungal biodiversity and dynamics during Massa Medicata Fermentata fermentation. Appl Microbiol Biotechnol (accepted)

2. Liu Y, Li QS, Zhu HL, Meng ZL, Xiang H, Xie Q. Purification and characterization of two thermostable glucoamylases produced by Aspergillus niger B-30. Chem. Res. Chinese Universities (accepted)

3. Kumano-Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S. Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. Biochem Biophys Res Commun. 2013 May 10; 434(3):594-9.

4. Kumano-Kuramochi M, Shimozu Y, Wakita C, Ohnishi-Kameyama M, Shibata T, Matsunaga S, Takano-Ishikawa Y, Watanabe J, Goto M, Xie Q, Komba S, Uchida K, Machida S. Identification of 4-hydroxy- 2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. Biochem J. 2012 Feb 15; 442(1):171-80.

5. Kumano-Kuramochi M, Ohnishi-Kameyama M, Xie Q, Niimi S, Kubota F, Komba S, Machida S. Minimum stable structure of the receptor for advanced glycation end product possesses multi ligand binding ability. Biochem Biophys Res Commun. 2009 Aug 14; 386(1):130-4.

6. Matsunaga S, Xie Q, Kumano-Kuramochi M, Komba S, Machida S. Silicone-urethane adhesive for improved coverslip mounting and leak-free preparation of living cell observation chambers. Biotechniques. 2009 Mar; 46(3):225-7.

7. Kumano-Kuramochi M, Xie Q, Sakakibara Y, Niimi S, Sekizawa K, Komba S, Machida S. Expression and characterization of recombinant C-terminal biotinylated extracellular domain of human receptor for advanced glycation end products (hsRAGE) in Escherichia coli. J Biochem. 2008 Feb; 143(2):229-36.

8. Matsunaga S, Xie Q, Kumano M, Niimi S, Sekizawa K, Sakakibara Y, Komba S, Machida S. Lectin-like oxidized low-density lipoprotein receptor (LOX-1) functions as an oligomer and oligomerization is dependent on receptor density. Exp Cell Res. 2007 Apr 1; 313(6):1203-14. Epub 2007 Jan 17. Erratum in: Exp Cell Res. 2007 Jul 15; 313(12):2752.

9. Takahashi H, Arai M, Takenawa T, Sota H, Xie QH, Iwakura M. Stabilization of hyperactive dihydrofolate reductase by cyanocysteine- mediated backbone cyclization. J Biol Chem. 2007 Mar 30; 282(13):9420-9.

10. Xie Q, Matsunaga S, Wen Z, Niimi S, Kumano M, Sakakibara Y, Machida S. In vitro system for high-throughput screening of random peptide libraries for antimicrobial peptides that recognize bacterial membranes. J Pept Sci. 2006 Oct; 12(10):643-52.

11. Ohki I, Ishigaki T, Oyama T, Matsunaga S, Xie Q, Ohnishi-Kameyama M, Murata T, Tsuchiya D, Machida S, Morikawa K, Tate S. Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure. 2005 Jun; 13(6):905-17.

12. Xie Q, Matsunaga S, Niimi S, Ogawa S, Tokuyasu K, Sakakibara Y, Machida S. Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells. DNA Cell Biol. 2004 Feb; 23(2):111-7.

13. Xie Q, Matsunaga S, Shi X, Ogawa S, Niimi S, Wen Z, Tokuyasu K, Machida S. Refolding and characterization of the functional ligand-binding domain of human lectin-like oxidized LDL receptor. Protein Expr Purif. 2003 Nov; 32(1):68-74.

14. Rice Full-Length cDNA Consortium. Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice. Science. 2003 Jul 18; 301(5631):376-9. Erratum in: Science. 2003 Sep; 301(5641):1849.


College of Life Sciences, Jilin University,Changchun,China,130012

Tel:+86-431-81969061  Email: smxyld@jlu.edu.cn