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师资队伍
顾景凯
基本情况
姓名: 顾景凯
性别:
职称: 教授
是否博导:
最高学位: 博士
Email:
详细情况
所在学科专业: 药学
所研究方向: 药代动力学研究、代谢组学研究、蛋白质组学研究等
讲授课程: 本科生:生物质谱
研究生:药物代谢
工作经历: 现任吉林大学生命科学院唐敖庆特聘教授,药物代谢研究中心主任。
2003 年12 月吉林大学,被聘为博士生导师;
2001 年9 月 吉林大学,破格晋升为教授;
2000 年1 月 吉林大学,副教授;
1997 年至2000 年 吉林大学化学系,博士后;
1994 年至1997 年 沈阳药科大学,获药物分析博士学位。
科研项目: 一、国家科技部项目
1、国家“十一五重大科技专项”:临床前药物代谢动力学技术平台(课题编号:2009ZX09304-003)2009.01-2010.12
2、国家“十一五重大科技专项”:新药防耐药突变浓度检测与组织内药物浓度测定 (课题编号:2009ZXJ09014-0097)
3、国家“十二五重大科技专项”:全程可监控数字化创新药物临床研究技术平台建设(课题编号:2012ZX09301)2012.7-2015.7
4、国家“十二五” 国家科技支撑计划课题“维吾尔、哈萨克药生物活性成分筛选和现代标准组分库建设”(课题编号:2012BAI30B02)2012.1-2014.12
5、国家“十二五重大科技专项”:抗癫痫一类新药-Q808胶囊的临床前研究(课题编号:2011ZX09102-003-03)2012.1-2014.12
6、科技部中俄国际合作专项“多肽肿瘤靶向抗肿瘤药物高分子载体的研究与开发”(2011DFR51090)

二、国家自然科学基金:
1、关于药物的葡萄糖醛酸化代谢研究(No.30070879)2001.1-2003.12
2、七叶皂苷四组分同时给药的代谢机理及相互关系研究 (No.30772613) 2008.1-2010.12
3、微管靶向型药物的亚细胞水平药代动力学研究(No.30973587) 2010.1-2012.12
4. 创新药物相关的药物代谢与动力学基础理论和新方法研究(No.39930180,重点项目,参与) 2000.1-2003.12

三、近五年承担横向课题:
(一)临床前项目
原人参二醇;氨苄西林/丙磺舒;水杨酸伪麻黄碱;华洋-001研究;TJW-01研究;FY-01研究 ;WZA-001研究 ;石杉碱甲微球研究;葫芦素研究;JSTHSYY研究;注射用赖氨酸七叶皂苷;奥曲肽微球;39肽动研究;苯胺洛芬;秋水仙碱;利培酮微球;注射用前列地尔胶束;替莫唑胺颅内缓释植入片;替莫唑胺酯栓;次血红素六;落新妇苷;注射用左旋泮托拉唑钠;注射用重组人胸腺素α1;胸腺五肽-胸腺七肽。
(二)人体药代动力学项目
埃他卡林、精氨酸七叶皂苷、重组人胸腺素α1、洛伐他汀、克拉霉素、阿奇霉素、氨咖敏甲麻胶囊、复方缬沙坦分散片、复方酚咖伪麻胶囊、甘草酸二胺、右美沙芬、依卡倍特、匹伐他汀、非洛地平、米屈肼、美托洛尔、普卢利沙星、非索非那定、伪麻黄碱、羟考酮、倍氯米松、硝酸甘油软膏、氨基葡萄糖、帕拉米韦三水合物、甲萘氢醌二磷酸酯钠、烟酸、沙利度胺、奥普力浓、雷贝拉唑、氯沙坦钾、依非巴特、兰地洛尔、注射用头孢替坦二钠、注射用左旋泮托拉唑钠、苯磺酸氨氯地平叶酸、盐酸头孢卡品酯、盐酸氨溴索、盐酸阿那格雷、伊潘立酮、注射用胡黄莲总苷等。
(三)药物人体生物等效性项目
二甲双胍、佐米曲普坦、左羟丙哌嗪、盐酸非索非那定、舍曲林、奥美拉唑、替米沙坦、吲哒帕胺、亮菌甲素、米格列醇、阿奇霉素、氨溴索、氨氯地平、格列吡嗪、曲尼司特、多潘立酮、磷霉素钙、依那普利、氟桂利嗪、阿那曲唑、格列美脲、纳美芬、阿莫西林克拉维酸钾、阿伦磷酸钠、阿夫唑嗪、雷尼替丁、西沙必利、格列美脲、罗红霉素、罗红霉素、石杉碱甲、谷氨酰胺、愈酚甲麻那敏、氢氯噻嗪、特啦唑嗪、辛伐他汀、左炔诺孕酮、塞洛多辛、瑞格列奈、洛伐他汀、氯雷他定、盐酸特比萘芬、瑞舒伐他汀钙、谷胱甘肽、阿戈美拉汀、氯沙坦钾.结合雌激素等。
学术论文: 近五年研究团队发表论文
1、Wang T, Ma W, Sun Y, Yang Y, Zhang W, Fawcett JP, Du H, Gu J. Ultra-sensitive assay for paclitaxel in intracellular compartments of A549 cells using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2013, 912:93-7.
2、Gai YY, Liu WH, Sha CJ, Wang YL, Sun YT, Li XJ, Paul Fawcett J, Gu JK. Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats J Ethnopharmacol. 2012, 143(1):249-255.
3、Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J. Paul Fawcett, Limei Zhao, Jiangkai Gu*. Determination of landiolol, an ultra-short-acting β1-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2012, 891-892, 7-11.
4、Guo, Y., Xu, X., Qi, W., Xie, C., Wang, G., Zhang, A., and Ge, Y. (2012) Synergistic antitumor interactions between gemcitabine and clofarabine, Molecular medicine reports 5, 734-738.
5、Hong Cao, Yan Yang*. Biocatalytic synthesis of poly(δ-valerolactone) using a thermophilic esterase from Archaeoglobus fulgidus as catalyst. Int. J. Mol. Sci. 2012, 13: 12232-12241.
6、Yan Yang, Quanshun Li*. Cell-debris self-immobilized thermophilic esterase: a novel biocatalyst for synthesizing aliphatic polyesters. J. Control. Release (Abstract for SIPCD) 2012, in press.
7、Yan Yang*. A novel thermohilic histone with promising gene transfection efficiency. J. Control. Release (Abstract for SIPCD) 2012, in press.
8、Yang Yu, Yan Yang*. Lipase/esterase-catalyzed synthesis of aliphatic polyesters via polycondensation: a review. Process Biochem. 2012, 47: 1027-1036.
9、Wantong Song, Mingqiang Li, Zhaohui Tang, Quanshun Li, Yan Yang, Huaiyu Liu, Taicheng Duan, Hua Hong, Xuesi Chen*. Methoxy poly(ethylene glycol)-b-poly (L-glutamic acid) loaded cisplatin and a combination with iRGD for the treatment of non-small cell lung cancers. Macromol. Biosci. 2012, in press.
10、Zhang, M., Wu, X., Cui, X., Gao, F., Zhang, C., Yang, Y., and Gu, J. (2011) Simultaneous Determination of Escin Ia and Its Isomer Isoescin Ia by LC-MS-MS: Application to a Pharmacokinetic Study of Escin Ia in Rats, Chromatographia 74, 243-250.
11、Zhang, M., Gao, F., Cui, X., Zhang, Y., Sun, Y., and Gu, J. (2011) Development and Validation of an Improved Method for the Quantitation of Sertraline in Human Plasma using LC-MS-MS and Its Application to Bioequivalence Studies, Journal of Chromatographic Science 49, 89-93.
12、Zhang, D., Wang, Z., Zhao, X., Lu, W., Gu, J., and Cui, Y. (2011) Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Single Doses of Bivalirudin in Healthy Chinese Subjects, Biological & Pharmaceutical Bulletin 34, 1841-1848.
13、Zhang, C., Cui, X., Yang, Y., Gao, F., Sun, Y., Gu, J., Fawcett, J. P., Yang, W., and Wang, W. (2011) Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats, Xenobiotica 41, 340-348.
14、Yang, Y., Tsifansky, M. D., Shin, S., Lin, Q., and Yeo, Y. (2011) Mannitol-Guided Delivery of Ciprofloxacin in Artificial Cystic Fibrosis Mucus Model, Biotechnology and Bioengineering 108, 1441-1449.
15、Yan Yang, Quanshun Li*. Lipase/esterase-catalyzed ring-opening polymerization: a green polymer synthesis technique. Process Biochem. 2011, 46: 1900-1908.
16、Yan Yang, Quanshun Li*. Lipase-catalyzed synthesis of poly(ε-caprolactone) and its solid-state properties characterization. Biocatal. Biotransform. 2011, 16: 1201-1207.
17、Basma Ibrahim, Michael Tsifansky, Yan Yang, Yoon Yeo*. Challenges and advances in development of inhalable drug formulations for cystic fibrosis lung disease. Expert Opin. Drug Del. 2011, 8: 451-466.
18、Muharnmad, F., Guo, M., Qi, W., Sun, F., Wang, A., Guo, Y., and Zhu, G. (2011) pH-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles via Intracelluar Dissolution of ZnO Nanolids, Journal of the American Chemical Society 133, 8778-8781.
19、Muhammad, F., Guo, M., Guo, Y., Qi, W., Qu, F., Sun, F., Zhao, H., and Zhu, G. (2011) Acid degradable ZnO quantum dots as a platform for targeted delivery of an anticancer drug, Journal of Materials Chemistry 21, 13406-13412.
20、Meng, H., Ren, J., Lv, Y., Lin, W., and Guo, Y. (2011) Association study of CYP3A5 genetic polymorphism with serum concentrations of carbamazepine in Chinese epilepsy patients, Neurology Asia 16, 39-45.
21、Meng, H., Guo, G., Ren, J., Zhou, H., Ge, Y., and Guo, Y. (2011) Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy, Epilepsy & Behavior 21, 27-30.
22、Iliuk, A. B., Hu, L., and Tao, W. A. (2011) Aptamer in Bioanalytical Applications, Analytical Chemistry 83, 4440-4452.
23、Ibrahim, B. M., Tsifansky, M. D., Yang, Y., and Yeo, Y. (2011) Challenges and advances in the development of inhalable drug formulations for cystic fibrosis lung disease, Expert Opinion on Drug Delivery 8, 451-466.
24、Hu, L., and Tao, W. A. (2011) Chemical enrichment of tyrosine phosphopeptides, Se pu = Chinese journal of chromatography / Zhongguo hua xue hui 29, 869-875.
25、Hu, L., Iliuk, A., Galan, J., Hans, M., and Tao, W. A. (2011) Identification of Drug Targets In Vitro and in Living Cells by Soluble-Nanopolymer-Based Proteomics, Angewandte Chemie-International Edition 50, 4133-4136.
26、Cui, X., Zhang, M., Guan, X., Yin, L., Sun, Y., Fawcett, J. P., and Gu, J. (2011) LC-MS-MS Determination of Troxerutin in Plasma and Its Application to a Pharmacokinetic Study, Chromatographia 73, 165-169.
27、Zhang, C., Wang, L., Yang, Y., Sun, Y., Zhang, J., Li, G., and Gu, J. (2010) Validated LC-MS/MS method for the determination of sarpogrelate in human plasma: Application to a pharmacokinetic and bioequivalence study in Chinese volunteers, Journal of Pharmaceutical and Biomedical Analysis 53, 546-551.
28、Zhang, C., and Gu, J. (2010) Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats, Drug Metabolism Reviews 43, 73-74.
29、Yang, Y., Tsifansky, M. D., Wu, C.-J., Yang, H. I., Schmidt, G., and Yeo, Y. (2010) Inhalable Antibiotic Delivery Using a Dry Powder Co-delivering Recombinant Deoxyribonuclease and Ciprofloxacin for Treatment of Cystic Fibrosis, Pharmaceutical Research 27, 151-160.
30、Wu, X., Liu, L., Zhang, M., Wu, D., Wang, Y., Sun, Y., Fawcett, J. P., Gu, J., and Zhang, J. (2010) Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study after oral administration, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 878, 861-867.
31、Liu, L., Wu, X., Wu, D., Wang, Y., Li, P., Sun, Y., Yang, Y., Gu, J., and Cui, Y. (2010) A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin Ib in human plasma: application to a pharmacokinetic study after intravenous administration, Biomedical Chromatography 24, 1309-1315.
32、Li, H., Zhang, C., Wang, J., Jiang, Y., Fawcett, J. P., and Gu, J. (2010) Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 51, 716-722.
33、Hu, L., Ye, M., and Zou, H. (2010) Peptidome analysis of mouse liver tissue by size exclusion chromatography prefractionation, Methods in molecular biology (Clifton, N.J.) 615, 207-216.
34、Gao, F., Zhang, M., Cui, X., Wang, Z., Sun, Y., and Gu, J. (2010) Simultaneous quantitation of hydrochlorothiazide and metoprolol in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 52, 149-154.
35、Zhao, X., Liu, Y., Xu, J., Zhang, D., Zhou, Y., Gu, J., and Cui, Y. (2009) Determination of silodosin in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877, 3724-3728.
36、Zhang, D., Wang, Y., Han, J., Yu, W., Deng, L., Fawcett, J. P., Liu, Z., and Gu, J. (2009) Rapid and sensitive LC-MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877, 581-585.
37、Zhang, C., Wang, L., Yang, W., Wang, X., Fawcett, J. P., Sun, Y., and Gu, J. (2009) Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat, Journal of Pharmaceutical and Biomedical Analysis 50, 41-45.
38、Yu, W., Wang, Y., Zhang, Y., Lan, J., Liu, Z., Gu, J., Fawcett, J. P., and Zhang, D. (2009) Quantitation of bergenin in human plasma by liquid chromatography/tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 877, 33-36.
39、Yang, Y., Bajaj, N., Xu, P., Ohn, K., Tsifansky, M. D., and Yeo, Y. (2009) Development of highly porous large PLGA microparticles for pulmonary drug delivery, Biomaterials 30, 1947-1953.
40、Wang, Y., Kong, L., Lei, X., Hu, L., Zou, H., Welbeck, E., Bligh, S. W. A., and Wang, Z. (2009) Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction, Journal of Chromatography A 1216, 2185-2191.
41、Tian, R., Ren, L., Ma, H., Li, X., Hu, L., Ye, M., Wu, R. a., Tian, Z., Liu, Z., and Zou, H. (2009) Selective enrichment of endogenous peptides by chemically modified porous nanoparticles for peptidome analysis, Journal of Chromatography A 1216, 1270-1278.
42、Sun, Y., Liu, M., Zhang, J., Jiang, Y., Yu, W., Fawcett, J. P., and Gu, J. (2009) Rapid and sensitive assay for trantinterol, a novel beta(2)-adrenoceptor agonist, in human plasma using liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 49, 1056-1059.
43、Si, D., Wang, Y., Zhou, Y.-H., Guo, Y., Wang, J., Zhou, H., Li, Z.-S., and Fawcett, J. P. (2009) Mechanism of CYP2C9 Inhibition by Flavones and Flavonols, Drug Metabolism and Disposition 37, 629-634.
44、Hu, L., Zhou, H., Li, Y., Sun, S., Guo, L., Ye, M., Tian, X., Gu, J., Yang, S., and Zou, H. (2009) Profiling of Endogenous Serum Phosphorylated Peptides by Titanium (IV) Immobilized Mesoporous Silica Particles Enrichment and MALDI-TOFMS Detection, Analytical Chemistry 81, 94-104.
45、Hu, L., Ye, M., and Zou, H. (2009) Recent advances in mass spectrometry-based peptidome analysis, Expert Review of Proteomics 6, 433-447.
46、Hu, L., Boos, K.-S., Ye, M., Wu, R. a., and Zou, H. (2009) Selective on-line serum peptide extraction and multidimensional separation by coupling a restricted-access material-based capillary trap column with nanoliquid chromatography-tandem mass spectrometry, Journal of Chromatography A 1216, 5377-5384.
47、Han, J., Jiang, S., Cui, X., Sun, Y., Li, G., Zhang, J., Fawcett, J. P., and Gu, J. (2009) Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 50, 171-174.
48、Chen, J., Gu, J., Zhao, R., Dai, R., and Wang, J. (2009) Simultaneous Nonchiral Determination of Artemisinin and Arteannuin B in Artemisia annua Using Circular Dichroism Detection, Chromatographia 69, 361-363.
49、Zhao, L., Li, H., Jiang, Y., Piao, R., Li, P., and Gu, J. (2008) Determination of ranolazine in human plasma by liquid chromatographic-tandem mass spectrometric assay, Journal of Chromatographic Science 46, 697-700.
50、Zhang, D., Du, X., Liu, M., Li, H., Jiang, Y., Zhao, L., and Gu, J. (2008) Determination of ecabet in human plasma by high-performance liquid chromatography-tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 863, 223-228.
51、Yang, Y., Li, H., Gao, K., Liu, M., Sun, Y., Yan, T., Fawcett, J. P., Cui, Y., and Gu, J. (2008) Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 862, 119-124.
52、Yan, T., Li, H., Deng, L., Guo, Y., Yu, W., Fawcett, J. P., Zhang, D., Cui, Y., and Gua, J. (2008) Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma, Journal of Pharmaceutical and Biomedical Analysis 48, 1225-1229.
53、Wu, R. a., Hu, L., Wang, F., Ye, M., and Zou, H. (2008) Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation, Journal of Chromatography A 1184, 369-392.
54、Wang, J., Jiang, Y., Wang, Y., Tang, Y., Teng, G., Fawcett, J. P., Kong, J., and Gu, J. (2008) A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies, Journal of Pharmaceutical and Biomedical Analysis 47, 985-989.
55、Wang, F., Ye, M., Dong, J., Tian, R., Hu, L., Han, G., Jiang, X., Wu, R. a., and Zou, H. (2008) Improvement of performance in label-free quantitative proteome analysis with monolithic electrospray ionization emitter, Journal of Separation Science 31, 2589-2597.
56、Gu, J., Liu, M., and Fawcett, J. P. (2008) PHARMACOKINETICS AND METABOLISM OF SOME POTENTIAL PRODRUGS OF O-DESMETHYLVENLAFAXINE, Drug Metabolism Reviews 40, 157-158.
57、Zhang, Y., Si, D., Chen, X., Lin, N., Guo, Y., Zhou, H., and Zhong, D. (2007) Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects, British Journal of Clinical Pharmacology 64, 67-74.
58、Zhang, X., Zhang, D., Xu, J., Gu, J., and Zhao, Y. (2007) Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 858, 65-70.
59、Wang, Y., Wang, Y., Li, P., Tang, Y., Fawcett, J. P., and Gu, J. (2007) Quantitation of Armillarisin A in human plasma by liquid chromatography-electrospray tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 43, 1860-1863.
60、Wang, Y., Kong, L., Hu, L., Lei, X., Yang, L., Chou, G., Zou, H., Wang, C., Bligh, S. W. A., and Wang, Z. (2007) Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 860, 185-194.
61、Wang, J., Jiang, Y., Wang, Y., Zhao, X., Cui, Y., and Gu, J. (2007) Liquid chromatography tandem mass spectrometry assay to determine the pharmacokinetics of aildenafil in human plasma, Journal of Pharmaceutical and Biomedical Analysis 44, 231-235.
62、Wang, J., Jiang, Y., Wang, Y., Li, H., Fawcett, J. P., and Gu, J. (2007) Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high-performance liquid chromatography/tandem mass spectrometry, Rapid Communications in Mass Spectrometry 21, 1755-1758.
63、Tian, R., Zhang, H., Ye, M., Jiang, X., Hu, L., Li, X., Bao, X., and Zou, H. (2007) Selective extraction of peptides from human plasma by highly ordered mesoporous silica particles for peptidome analysis, Angewandte Chemie-International Edition 46, 962-965.
64、Tian, R., Ye, M., Hu, L., Li, X., and Zou, H. (2007) Selective extraction of peptides in acidic human plasma by porous silica nanoparticles for peptidome analysis with 2-D LC-MS/MS, Journal of Separation Science 30, 2204-2209.
65、Teng, G., Wang, Y., Tang, Y., Wang, R., Fang, Y., Fawcett, J. P., and Gu, J. (2007) Quantitation of iptakalim in human plasma by high-performance liquid chromatography-tandem mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 859, 256-260.
66、Su, X., Kong, L., Lei, X., Hu, L., Ye, M., and Zou, H. (2007) Biological fingerprinting analysis of traditional Chinese medicines with targeting ADME/Tox property for screening of bioactive compounds by chromatographic and MS methods, Mini-Reviews in Medicinal Chemistry 7, 87-98.
67、Su, X., Hu, L., Kong, L., Lei, X., and Zou, H. (2007) Affinity chromatography with immobilized DNA stationary phase for biological fingerprinting analysis of traditional Chinese medicines, Journal of Chromatography A 1154, 132-137.
68、Liu, M., Zhang, D., Sun, Y., Wang, Y., Liu, Z., and Gu, J. (2007) Liquid chromatographic-electrospray tandem mass spectrometric determination of bisoprolol in human plasma, Biomedical Chromatography 21, 508-513.
69、Li, X., Wang, Y., Wang, J., Fawcett, J. P., Zhao, L., and Gu, J. (2007) Determination of miglitol chromatography/tandem in human plasma by liquid mass spectrometry, Rapid Communications in Mass Spectrometry 21, 247-251.
70、Li, H., Wang, Y., Jiang, Y., Tang, Y., Wang, J., Zhao, L., and Gu, J. (2007) A liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of valsartan and hydrochlorothiazide in human plasma, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 852, 436-442.
71、Jiang, Y., Wang, J., Wang, Y., Li, H., Fawcett, J. P., and Gu, J. (2007) Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of colchicine in human plasma, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 850, 564-568.
72、Jiang, Y., Wang, J., Wang, Y., Du, X., Zhang, Y., Fawcett, J. P., and Gu, J. (2007) Determination of long-acting release octreotide, an octapeptide analogue of in human plasma by liquid somatostation, chromatography/tandem mass spectrometry, Rapid Communications in Mass Spectrometry 21, 3982-3986.
73、Jiang, Y., Wang, J., Li, H., Wang, Y., and Gu, J. (2007) Determination of clarithromycin in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 43, 1460-1464.
74、Hu, L., Ye, M., Jiang, X., Feng, S., and Zou, H. (2007) Advances in hyphenated analytical techniques for shotgun proteome and peptidome analysis - A review, Analytica Chimica Acta 598, 193-204.
75、Hu, L., Li, X., Jiang, X., Zhou, H., Jiang, X., Kong, L., Ye, M., and Zou, H. (2007) Comprehensive peptidome analysis of mouse livers by size exclusion chromatography prefractionation and NanoLC-MS/MS identification, Journal of Proteome Research 6, 801-808.
着作教材: 1、《缓控释制剂药物动力学》,科学出版社,2009年,合作主编
2、《临床药物动力学》,科学出版社,2010年,编委
获奖情况: 王睿,柴栋,王瑾,顾景凯,蔡芸,梁蓓蓓,白楠,朱曼,裴斐;军队特需新药临床研究关键技术平台构建与应用;2011 年,中国人民解放军科学技术进步奖二等奖(证书号:2011-2-46-4)
社会兼职: 兼任分子酶学工程教育部重点实验室、理论化学国家重点实验室、艾滋病疫苗国家工程实验室教授,山东绿叶“长效缓控释和靶向技术国家重点实验室”学术委员会委员,美国化学会会员,国家药品审评中心评审专家。中国药理学会药物代谢专业委员、中国药理学会临床药理专业委员、中国药学会药物分析专业委员、中国药学会应用药理学会专业委员、吉林省药学会药物化学专业委员会副主任、《药学学报》、《药学学报英文版》、《中国药理学通报》编委。

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