师资队伍

微生物学与免疫学系

吴慧

日期:2020-08-11 点击数: 来源:

姓 名:

吴慧

职 称:

副教授

最高学位:

博士

电 话:

0431-85167795

邮 件:

topwuhui@jlu.edu.cn

工作地点:

吉林大学生命科学学院413室

研究方向

慢性非传染性疾病的疫苗和分子机制研究,包括双靶向阿尔茨海默症疫苗及其作用机制研究,以及恶性肿瘤的侵袭转移机制研究

教育经历

2006/09-2011/07,中国协和医科大学,北京生命科学研究所,博士

2002/09-2006/07,北京师范大学,生命科学学院,学士

工作经历

2015/9-至今,吉林大学,生命科学学院,艾滋病疫苗国家工程实验室,副教授

2013/08-2015/8,吉林大学,生命科学学院,艾滋病疫苗国家工程实验室,讲师

2011/09-2013/07,吉林大学,生命科学学院,艾滋病疫苗国家工程实验室,博士后

研究成果

主持科研项目:

1. 国家自然科学基金面上基金项目,31971142,磷酸化tau调控神经元发生程序性坏死的作用及机制研究,2020/01-2023/12,58万元,主持

2. 吉林省科技发展计划自然科学基金项目,20190201185JC,双靶向Aβ和pTau的新型阿尔茨海默病疫苗研究,2019/01-2021/12,10万元,主持

3. 吉林省教育厅科学研究规划项目,JJKH20200949KJ, Tau诱导AD神经元发生程序性坏死的作用机理研究, 2019/01- 2021/12, 2.5万元,主持

4. 横向项目,老年痴呆疫苗的研发,2016/08-2021/12,30万元,主持

5. 吉林省教育厅 “十三五”科学技术研究规划项目,吉教科合字[2016] 437号,阿尔茨海默症早期治疗型疫苗的临床前研究,2016/1-2018/12,3万元,主持

6. 国家科技重大专项课题校内子项,2014ZX09304314-001-03,以survivin和MUC1为靶点重组腺病毒载体肿瘤治疗性疫苗的临床前安全性评价,2015/01-2016/12,30万,主持

7. 吉林大学青年师生学科交叉培育项目,JCKY-QKJC03,转移型乳腺癌患者外周血中转移肿瘤干细胞的分离纯化及特性研究,2014/04-2016/04 ,10万元,主持

8. 吉林省科技发展计划青年科学基金项目,20140520008JH,阿尔茨海默症蛋白疫苗研究,2014/01-2016/12,5万元,主持

9. 国家自然科学基金青年科学基金项目,81301803,Snail、G9a和CDYLb在肝癌EMT和侵袭转移过程中的作用及机制研究,2014/01-2016/12,23万元,主持

10. 中国博士后科学基金第54批面上资助一等资助,2013M540246,G9a和CDYLb在肝癌EMT和侵袭转移过程中的作用机制研究,2013/05-2014/10,8万元,主持

代表性期刊论文:

1.Hu Y, Nie Q, Dai M, Chen F*, Wu H*, Histone Deacetylases Inhibit the Snail2-Mediated EMT During Metastasis of Hepatocellular Carcinoma Cells, Frontiers in Cell and Developmental Biology,2020, 5;8:752

2.Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Zheng Y, Fu L, Yu B, Zhang H, Wu J, Yu X, Wu H*, Kong W*, The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease. Journal of neuroinflammation, 2020, 17(1):72

3.Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H*, Yu X*, G9aand histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Science, 2019, 110(11):3442-3452

4.Hu Y, Zheng Y, Dai M, Wu J, Yu B, Zhang H, Kong W, Wu H*, Yu X*, Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs. Cell Adhesion and Migration. 2019, 13(1):285-292

5.Yang P, Guo Y, Sun Y, Yu B, Zhang H, Wu J, Yu X, Wu H*, Kong W*, Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice. BMC Immunology 2019, 20: 9

6.Hu Y, Dai M, Zheng Y, Wu J, Yu B, Zhang H, Kong W, Wu H*, Yu X*, Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer. Clinical epigenetics, 2018, 10(1):154

7.Fu L, Guo Y, Sun Y, Dong Y, Wu J, Yu B, Zhang H, Yu X, Wu H*, Kong W*, A novel Aβ epitope vaccine based on bacterium-like particle against Alzheimer's disease. Molecular immunology, 2018, 101:259-267.

8.Fu L, Sun Y, Guo Y, Yu B, Zhang H, Wu J, Yu X, Wu H*, Kong W*, Progressive spatial memory impairment, brain amyloid deposition and changes in serum amyloid levels as a function of age in APPswe/PS1dE9 mice. Current Alzheimer Research, 2018, 15: 1-9

9.Fu L, Li Y, Hu Y, Zheng Yn, Yu B, Zhang H, Wu J, Wu H*, Yu X*, Kong W*, A norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in mouse model of Alzheimer’s disease. Scientific Reports, 2017, 2017, 7: 41041

10.Fu L , Li Y, Hu Y, Yu B, Zhang H, Wu J, Wu H*, Yu X*, Kong W*. Norovirus P particle: an excellent vaccine platform for antibody production against Alzheimer’s disease. Immunology Letters, 2015, 168(1):22-30.

11.Wang X, Wang X, Wang W, Zhang J, Wang J, Wang C, Lv M, Zuo T, Liu D, Zhang H, Wu J, Yu B, Kong W, Wu H*, Yu X*. Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro. Biochemical and biophysical research communications, 2015, 461(4):624-9

12.Liu N*, Zhang Z*, Wu H*,#, Jiang Y, Meng L, Xiong J, Zhao Z, Zhou X, Li J, Li H, Zheng Y, Chen S, Cai T, Gao S, Zhu B#. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes & development, 2015, 29(4):379-93

13.Wu H*, Zhang H*, Wang P, Mao Z, Feng L, Wang Y, Liu C, Xia Q, Li B, Zhao H, Chen Y, Wu J, Kong W*, Yu X*, Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas. Genes chromosomes & cancer, 2013, 52(7):644-655

14.Wu H, Chen X, Xiong J, Li Y, Li H, Ding X, Liu S, Chen S, Gao S, Zhu B. Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Research, 2011, 21(2): 365-7