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师资队伍
蔡林君
基本情况
姓名: 蔡林君
性别:
职称: 副教授
最高学历: 研究生
最高学位: 博士
Email:
详细情况
所在学科专业: 微生物学、免疫学
所研究方向: 病原微生物与免疫;疾病生物标志物
讲授课程: 免疫学原理;分子仿生学
教育经历: 2007.09–2009.03 瑞典 乌普萨拉大学医学院 医学科学系 联合培养博士研究生
2006.09–2009.07 吉林大学 预防兽医学系 预防兽医学专业 博士研究生
2004.09–2006.07 长春理工大学 生命科学学院 应用生物化学专业 硕士研究生
1999.09–2003.07 长春师范大学 生物系 生物科学专业 本科生
工作经历: 2016.01- 至今 吉林大学 生命科学学院 艾滋病疫苗国家工程实验室
2012.05–2015.12 吉林大学 工程仿生教育部重点实验室 学术骨干 副教授
2009.10–2012.03 日本 大阪大学 WPI免疫学前沿研究中心(WPI-IFReC)博士后
科研项目: 1.国家自然科学青年基金;不同分子形式中性粒细胞明胶酶相关载脂蛋白(NGAL)早期诊断急性肾损伤的价值及机理研究(项目编号:81401717);2015.01~2017.12;经费23万元;项目负责人。
2.教育部留学回国人员科研启动基金;二氧化钛(TiO2)纳米仿生界面对高内皮细胞影响及机理研究;2015.01~2016.12;经费3万元;项目负责人。
3.吉林省科技厅产业技术创新战略联盟;临床POCT快速检验技术及系列产品研制(项目编号:20140309013YY);2014.01~2016.12;项目总经费70万元,吉林大学方子项目经费7万元;吉林大学方项目负责人。
4. 吉林省科技厅重点科研攻关项目;基于HNL/NGAL的急性肾损伤早期诊断方法及其快速诊断试剂盒的研发(项目编号:20130206011YY);2013.01~2015.12;经费12万元;项目负责人。
5. 吉林大学工程仿生教育部重点实验室开放课题;二氧化钛纳米仿生材料的制备及应用研究;2013.01-2013.12;经费4万元;项目负责人。
6. 吉林大学基本科研业务费2万元;HNL/NGAL分子形式研究;项目负责人。
7.吉林大学人才引进科研启动经费4万元;项目负责人。
8.吉林大学学术骨干引进科研配套经费25万元;项目负责人。
学术论文: 一、学术论文
(1)Zhu,J., Jiang M., Ma H., Zhang H., Cheng W., Li J., Cai L., Han X.,* and Zhao B.(2019) The Redox State Regulates Cyt c Release in Apoptosis Revealed by Surface-enhanced Raman Scattering on Nickel Substrates. Angewandte Chemie International Edition, DOI: 10.1002/anie. 201909638.(IF=12.257)

(2)Wang, J., Teng, Y., Zhao, G., Li, F., Hou, A., Sun, B., Kong, W., Gao, F., Cai, L.*, and Jiang, C.* (2019). Exosome-Mediated Delivery of Inducible miR-423-5p Enhances Resistance of MRC-5 Cells to Rabies Virus Infection. International Journal of Molecular Sciences 20, 1537.(IF=4.183)

(3)Jiang, M., Xie, H., Zhu, J., Ma, H., Zheng, N., Li, S., Xiao, J., Wang, Y., Cai, L.*, and Han, X. (2019). Molecular Form-specific Immunoassays for Neutrophil Gelatinase-associated Lipocalin by Surface-enhanced Raman Spectroscopy. Sensors and Actuators B: Chemical 297, 126742.(IF=6.393)

(4)Wang, J., Wu F., Liu C., Dai W., Teng Y., Su W., Kong W., Gao F., Cai L., Hou A. and Jiang C. (2019). Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process. Virologica Sinica 34, 59-65.

(5)Kou, Y., Wan, M., Shi, W., Liu, J., Zhao, Z., Xu, Y., Wei, W., Sun, B., Gao, F., Cai, L.*, and Jiang, C.* (2018) Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis, Journal of Microbiology and Biotechnology 28, 1022-1029.

(6)Kou, Y., Xu, Y., Zhao, Z., Liu, J., Wu, Y., You, Q., Wang, L., Gao, F., Cai, L.*, and Jiang, C.* (2017) Tissue Plasminogen Activator (tPA) Signal Sequence Enhances Immunogenicity of MVA-Based Vaccine Against Tuberculosis, Immunology Letters. 190, 51-57.

(7)Cai, L., Li, J., Wang, S. P., Zhao, M. Z., Zhao, B. G., Jiang, C*., and Kong, W. (2017) Functionalization of Magnetic Titanium Dioxide for Targeted Drug Delivery and UV-induced Release, Chemical Research in Chinese Universities, 33, 294-297.

(8)Cai, L.*, Chen, L., Zhang, L., Lu, G., He, X., Zhang, S., Sun, H., Liu, Z., and Zhao, B. (2013) Recyclable, Biocompatible, Magnetic Titanium Dioxide Nanoparticles with Immobilized Enzymes for Biocatalysis, Chempluschem 78, 1437-1439.

(9)Bai, Z. #, Cai, L.#, Umemoto, E. #, Takeda, A.#, Tohya, K., Komai, Y., Veeraveedu, P. T., Hata, E., Sugiura, Y., Kubo, A., Suematsu, M., Hayasaka, H., Okudaira, S., Aoki, J., Tanaka, T., Albers, H. M., Ovaa, H., and Miyasaka, M*. (2013) Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis, The Journal of Immunology, 190, 2036-2048.(# contributed equally)(IF=4.718,他引80次)

(10)Cai, L.*, B., Z., Umemoto, E., Hayasaka, H., Miyasaka, M. (2011) The Role of the Autotaxin/LPA Axis and Its Role in Lymphocyte Trafficking into Lymph Nodes, Japanese Journal of Lymphology 34, 4.

(11)Cai, L., Rubin, J., Han, W., Venge, P.*, and Xu, S*. (2010) The Origin of Multiple Molecular Forms in Urine of HNL/NGAL, Clinical Journal of the American Society of Nephrology, 5, 2229-2235.(IF=6.243,他引180次)

(12)Cai, L., Borowiec, J., Xu, S., Han, W., and Venge, P*. (2009) Assays of Urine Levels of HNL/NGAL in Patients Undergoing Cardiac Surgery and the Impact of Antibody Configuration on their Clinical Performances, Clinica Chimica Acta, 403, 121-125.(IF=2.9,他引60次)

(13)Wang, J., Wu, F., Liu, C., Dai W., Teng Y., Su W., Kong W., Gao F., Cai L., Hou A., and Jiang C. (2019) Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process, Virologica Sinica, 34: 59-65.

(14)Zhao, D., Sun, B., Sun, S., Fu, B., Liu, C., Liu, D., Chu, Y., Ma, Y., Bai, L., Wu, Y., Zhou, Y., Su, W., Hou, A., Cai, L., Xu, F., Kong, W., and Jiang, C.* (2017) Characterization of Human Enterovirus71 Virus-like Particles Used for Vaccine Antigens, PLoS One 12, e0181182.

(15)Wang, D., Di, X., Fu, L., Li, Y., Han, X., Wu, H., Cai, L., Meng, X., Jiang, C.*, Kong, W., and Su, W*. (2016) Analysis of Serum Beta-amyloid Peptides, Alpha2-macroglobulin, Complement factor H, and Clusterin Levels in APP/PS1 Transgenic Mice During Progression of Alzheimer's Disease, Neuroreport 27, 1114-1119.

(16)Chen, L., Cai, L., Ruan, W., and Zhao, B*. (2013) Surface-enhanced Raman Spectroscopy (SERS): Protein Application, In Encyclopedia of Analytical Chemistry, John Wiley & Sons, Ltd.

(17)Umemoto, E., Hayasaka, H., Bai, Z., Cai, L., Yonekura, S., Peng, X., Takeda, A., Tohya, K., and Miyasaka, M*. (2011) Novel Regulators of Lymphocyte Trafficking Across High Endothelial Venules, Critical Reviews in Immunology, 31, 147-169.(他引35次)

(18)Xu, S.*, Cai, L., Zhao, L., Douhan-Hakansson, L., Kristjansson, G., Pauksen, K., and Venge, P. (2010) Tissue Localization and the Establishment of a Sensitive Immunoassay of the Newly Discovered Human Phospholipase B-precursor (PLB-P), Journal of Immunological Methods, 353, 71-77.

(19)Zhao, R., Han, J., Han, W*., Lei, L., Sun, C., Feng, X., Jiang, L., Qiao, H., and Cai, L. (2009) Molecular Cloning of Two Novel Temporins From Lithobates catesbeianus and Studying of Their Antimicrobial Mechanisms, Progress in Biochemistry and Biophysics 36, 1064-1070.

(20)Han, X., Cai, L., Guo, J., Wang, C., Ruan, W., Han, W., Xu, W., Zhao, B.*, and Ozaki, Y*. (2008) Fluorescein Isothiocyanate Linked Immunoabsorbent Assay Based on Surface-enhanced Resonance Raman Scattering, Analytical Chemistry, 80, 3020-3024.(IF=6.35,他引100次)

(21)Bai, B., Cai, L., Umemoto E., Takeda, A., Ikeno T., Hata, E., Hayasaka, H., and Miyasaka, M. * (2011) A New Molecular Mechanism Responsible for Lymphocyte Trafficking-role of the Physiologically Active Lipogenic Enzyme Autotaxin and Its Product Lysophosphatidic Acid, Inflammation & Immunity (in Japanese), 19, 450-455.

二、授权专利:
1.一种可再生的磁性固定化酶载体及其制备方法.专利号:ZL201310544114.8;蔡林君;陈雷;赵冰.2016
2.一种同步联合定量检测不同分子形式人中性粒细胞脂质运载蛋白的免疫层析装.专利号:ZL201620555293.4; 蔡林君;杨津;陈雷;赵冰;姜春来;孔维.2017
3.一种基于酶联免疫吸附技术的人中性粒细胞载脂蛋白异源二聚体定量装置.专利号:ZL201620555162.6;蔡林君;杨津;陈雷;姜春来;孔维.2017
4.一种人中性粒细胞载脂蛋白同源二聚体的定量装置.专利号:ZL201620555163.0; 蔡林君;姜春来;孔维.2017

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