研究成果 |
主持科研项目： 1、横向项目，新型双靶向阿尔茨海默症疫苗的开发，2021/08-2022/12，120万 2、国家自然科学基金面上基金项目，31971142，磷酸化tau调控神经元发生程序性坏死的作用及机制研究，2020/01-2023/12，58万 3、吉林省科技发展计划自然科学基金项目，20190201185JC，双靶向Aβ和pTau的新型阿尔茨海默病疫苗研究，2019/01-2021/12，10万 4、吉林省教育厅科学研究规划项目，JJKH20200949KJ, Tau诱导AD神经元发生程序性坏死的作用机理研究, 2019/01- 2021/12, 2.5万 5、横向项目，老年痴呆疫苗的研发，2016/08-2021/12，30万 6、吉林省教育厅 “十三五”科学技术研究规划项目，吉教科合字[2016] 437号，阿尔茨海默症早期治疗型疫苗的临床前研究，2016/1-2018/12，3万 7、国家科技重大专项课题校内子项，2014ZX09304314-001-03，以survivin和MUC1为靶点重组腺病毒载体肿瘤治疗性疫苗的临床前安全性评价，2015/01-2016/12，30万 8、吉林大学青年师生学科交叉培育项目，JCKY-QKJC03，转移型乳腺癌患者外周血中转移肿瘤干细胞的分离纯化及特性研究，2014/04-2016/04 ，10万 9、吉林省科技发展计划青年科学基金项目，20140520008JH，阿尔茨海默症蛋白疫苗研究，2014/01-2016/12，5万 10、国家自然科学基金青年科学基金项目，81301803，Snail、G9a和CDYLb在肝癌EMT和侵袭转移过程中的作用及机制研究，2014/01-2016/12，23万 11、中国博士后科学基金第54批面上资助一等资助，2013M540246，G9a和CDYLb在肝癌EMT和侵袭转移过程中的作用机制研究，2013/05-2014/10，8万 代表性期刊论文： 1、Sun Y*, Guo Y*, Feng X, Fu L, Zheng Y, Dong Y, Zhang Y, Yu X, Kong W, Wu H#, Norovirus P particle-based tau vaccine-generated phosphorylated tau antibodies markedly ameliorate tau pathology and improve behavioral deficits in mouse model of Alzheimer’s disease. Signal Transduction and Targeted Therapy, 2021, 6(1):61. 2、Dai M, Feng X, Mo Z, Sun Y, Fu L, Zhang Y, Wu J, Yu B, Zhang H, Yu X, Wu H#,Kong W#, Stimulation Effects and Mechanisms of Different Adjuvants on a Norovirus P Particle-Based Active Amyloid-β Vaccine. Journal of Alzheimers Disease, 2020,77(4):1717-1732 3、Hu Y, Nie Q, Dai M, Chen F#, Wu H#, Histone Deacetylases Inhibit the Snail2-Mediated EMT During Metastasis of Hepatocellular Carcinoma Cells. Frontiers in Cell and Developmental Biology,2020,8:752 4、Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Zheng Y, Fu L, Yu B, Zhang H, Wu J, Yu X, Wu H#, Kong W#, The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease. Journal of neuroinflammation, 2020, 17(1):72 5、Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H#, Yu X#, G9aand histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Science, 2019, 110(11):3442-3452 6、Hu Y, Zheng Y, Dai M, Wu J, Yu B, Zhang H, Kong W, Wu H#, Yu X#, Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs. Cell Adhesion and Migration. 2019, 13(1):285-292 7、Yang P, Guo Y, Sun Y, Yu B, Zhang H, Wu J, Yu X, Wu H#, Kong W#, Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice. BMC Immunology, 2019, 20: 9 8、Hu Y, Dai M, Zheng Y, Wu J, Yu B, Zhang H, Kong W, Wu H#, Yu X#, Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer. Clinical epigenetics, 2018, 10(1):154 9、Fu L, Guo Y, Sun Y, Dong Y, Wu J, Yu B, Zhang H, Yu X, Wu H#, Kong W#, A novel Aβ epitope vaccine based on bacterium-like particle against Alzheimer's disease. Molecular immunology, 2018, 101:259-267. 10、Fu L, Sun Y, Guo Y, Yu B, Zhang H, Wu J, Yu X, Wu H#, Kong W#, Progressive spatial memory impairment, brain amyloid deposition and changes in serum amyloid levels as a function of age in APPswe/PS1dE9 mice. Current Alzheimer Research, 2018, 15: 1-9 11、Fu L, Li Y, Hu Y, Zheng Yn, Yu B, Zhang H, Wu J, Wu H#, Yu X#, Kong W#, A norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in mouse model of Alzheimer’s disease. Scientific Reports, 2017, 2017, 7: 41041 12、Fu L , Li Y, Hu Y, Yu B, Zhang H, Wu J, Wu H#, Yu X#, Kong W#. Norovirus P particle: an excellent vaccine platform for antibody production against Alzheimer’s disease. Immunology Letters, 2015, 168(1):22-30. 13、Wang X, Wang X, Wang W, Zhang J, Wang J, Wang C, Lv M, Zuo T, Liu D, Zhang H, Wu J, Yu B, Kong W, Wu H#, Yu X#. Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro. Biochemical and biophysical research communications, 2015, 461(4):624-9 14、Liu N*, Zhang Z*, Wu H*,#, Jiang Y, Meng L, Xiong J, Zhao Z, Zhou X, Li J, Li H, Zheng Y, Chen S, Cai T, Gao S, Zhu B#. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes & development, 2015, 29(4):379-93 15、Wu H*, Zhang H*, Wang P, Mao Z, Feng L, Wang Y, Liu C, Xia Q, Li B, Zhao H, Chen Y, Wu J, Kong W#, Yu X#, Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas. Genes chromosomes & cancer, 2013, 52(7):644-655 16、Wu H, Chen X, Xiong J, Li Y, Li H, Ding X, Liu S, Chen S, Gao S, Zhu B#. Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Research, 2011, 21(2): 365-7 |
