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张勇
基本情况
姓名: 张勇
性别:
职称: 讲师
最高学历: 研究生
最高学位: 博士
电话:
Email:
详细情况
所在学科专业: 药学
所研究方向: 1.生物高分子材料及新型药物传递载体;2.疫苗佐剂;
讲授课程: 本科生实验课:药剂学Ⅰ实验;
本科生理论课:药剂学Ⅱ;生物药剂学与药代动力学;
教育经历: 2008—2009年 University of East Anglia,药学院,访问学者
2003—2009年 沈阳药科大学,药学院,药物制剂理学博士
1998—2003年 沈阳药科大学,药学院,药学(日语)理学学士
工作经历: 2012—现在 吉林大学,生命科学学院,讲师
2010—2012年 吉林大学,生命科学学院,博士后
科研项目: 承担项目
1. 吉林省产业技术创新战略联盟项目子课题:新型疫苗佐剂研究(资助编号:20140309007YY-02;执行年限:2015.1-2017.12),25万元,项目负责人。
2.十二五重大传染病科技专项子课题项目:DNA疫苗生产工艺研究(资助编号:2012ZX10001-009-06;执行年限2012.6-2015.12),40万元,项目负责人。
3. 吉林大学中央高校基本科研业务费项目:Zein/PLGA微粒载体用于化学修饰艾塞那肽跨细胞传递研究(执行年限:2013.01-2014.12),5万元,项目负责人。
4. 省自然科学基金项目:功能化壳聚糖/PLGA纳米粒用于化学修饰胸腺五肽口服传递研究(资助编号:C2011319001;执行年限:2011.1—2013.12),10万元,项目负责人。
5. 中国博士后科学基金面上项目:化学修饰免疫调节剂胸腺五肽/壳聚糖-EDTA-bestatin纳米粒口服传递研究(资助编号:20110491321;执行年限:2011.1—2012.8),3万元,项目负责人。
参与项目
1. 国家自然科学基金-英国皇家学会国际合作项目:单相溶液冻干技术制备蛋白多肽药物传递载体及载体的表征和应用(资助编号:30711130240;执行年限:2007.4—2008.12),主要完成人。
2. 国家自然科学基金面上项目: 甘露糖修饰胆盐多囊脂质体口服疫苗传递系统(资助编号:30672555;执行年限:2007.1—2009.12),主要参加人
学术论文: Selected Publications:
1. Zhang Y*, Cui LL, Li F, Shi NQ, Li CL, Yu XH, Chen Y*, Kong W. Design, fabrication and biomedical applications of zein-based nano/micro-carrier systems. Int J Pharm. 2016,513(1-2):191-210.
2. Zhang Y*, Feng J, Cui LL, Zhang YB, Li WZ, Li CL, Shi NQ, Chen Y*, Kong W. Investigation into efficiency of a novel glycol chitosan-bestatin conjugate to protect thymopoietin oligopeptides from enzymatic degradation. J Pharm. Sci.(Ronald T. Borchardt Dedicated Issue) 2016,105(2): 828-837.
3. Sun YN, Wang MS, Sun BX, Li F, Liu SB, Zhang Y*, Zhou Y, Chen Y*, Kong W.An investigation into the gastrointestinal stability of exenatide in the presence of pure enzymes, everted intestinal rings and intestinal homogenates. Biol Pharm Bull. 2016,39(1):42-48.
4. Zhang Y*, Cui LL, Chen Y, Zhang H, Zhong J, Sun YN, Shi NQ, Li CL, Kong W*. Zein-based nanofibres for drug delivery: Classes and current applications. Curr Pharm Des. 2015,21(22):3199-3207.
5. Zhang Y*, Cui LL, Che XX, Zhang H, Shi NQ, Li CL, Chen Y*, Kong W. Zein-based films and their usage for controlled delivery: Origin, classes and current landscape. J Control Release. 2015,206:206-217.
6. Shi NQ*, Qi XR*, Xiang B, Zhang Y. A survey on “Trojan Horse” peptides: Opportunities, issues and controlled entry to "Troy". J Control Release. 2014,194:53-70.
7. Wang MS, Zhang Y, Sun BX, Sun YN, Gong X, Wu YG, Zhang XZ, Kong W*, Chen Y*. Permeability of Exendin-4-Loaded Chitosan Nanoparticles across MDCK Cell Monolayers and Rat Small Intestine. Biol Pharm Bull. 2014,37(5):740-747.
8. Wang MS, Zhang Y, Feng J, Gu TJ, Dong QG, Yang X, Sun YN, Wu YG, Chen Y*, Kong W*. Preparation, characterization, and in vitro and in vivo investigation of chitosan-coated poly (d,l-lactide-co-glycolide) nanoparticles for intestinal delivery of exendin-4. Int. J. Nanomedicine. 2013,8:1141-54.
9. Dong QG, Zhang Y, Wang MS, Feng J, Zhang HH, Wu YG, Gu TJ, Yu XH, Jiang CL, Chen Y*, Li W, Kong W*. Improvement of enzymatic stability and intestinal permeability of deuterohemin-peptide conjugates by specific multi-site N-methylation. Amino Acids. 2012,43(6):2431-41.
10. Wang MS, Sun BX, Feng J, Zhang HH, Liu B, Li C, Chen Y*, Zhang Y*, Kong W. Investigation of transport mechanism of exendin-4 across MDCK cell monolayers. Biol. Pharm. Bull. 2012,35(5):745-52.
11. Zhang Y*, Deng YJ, Wang XL, Xu JH, Li ZQ*. Conformational and bioactivity analysis of insulin: freeze-drying TBA/water co-solvent system in the presence of surfactant and sugar. Int. J. Pharm. 2009,371(1-2):71-81.
12. Zhang Y, Deng YJ*, Lu M, Duncan Q.M. Craig, Li ZQ*. A spectroscopic investigation into interaction between bile salts and insulin in alkaline aqueous solution. J. Colloid Interface Sci. 2009,337(2):322-331.
13. Hao AJ, Deng YJ*, Li TF, Suo XB, Cao YH, Hao YL, Zhang Y. Degradation kinetics of fluorouracil-acetic-acid-dextran conjugate in aqueous solution. Drug Dev. Ind. Pharm. 2006,32(6):757-63.
14. Hao YL, Deng YJ*, Chen Y, Wang KZ, Hao AJ, Zhang Y. In-vitro cytotoxicity, in-vivo biodistribution and antitumor effect of PEGylated liposomal topotecan. J. Pharm. Pharmacol. 2005,57: 1279-1287.

专利
1. 张勇,陈妍,孔维。苯丁抑制素乙二醇壳聚糖及其制备方法(专利号201410260315.x)
着作教材: 1. 第十七章 脂质体在其他给药系统中的应用.《脂质体技术》(主编:邓英杰,书号:ISBN:978-7-117-08409-3/R.8410),人民卫生出版社,2007。
2. Zhang Y*, Cui LL, Chen Y and Kong W. Chapter 1: Exendin-4 and Its Derivatives for Diabetes and Obesity: Old Story and New Hope, in Ed, Atta-ur-Rahman, Frontiers in Clinical Drug Research- Diabetes and Obesity, Bentham Science Publishers, 2016, volume 3, page: 3-58. ISBN: 978-1-68108-248-6.

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