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张勇
基本情况
姓名: 张勇
性别:
职称: 副教授
最高学历: 研究生
最高学位: 博士
电话:
Email:
详细情况
所在学科专业: 药学
所研究方向: 1.生物高分子材料及新型药物传递载体;2.疫苗佐剂;
讲授课程: 本科生实验课:药剂学Ⅰ实验;
本科生理论课:药剂学Ⅱ;生物药剂学与药代动力学;
教育经历: 2008—2009年 University of East Anglia,药学院,联合培养博士
2003—2009年 沈阳药科大学,药学院,药物制剂 理学博士
1998—2003年 沈阳药科大学,药学院,药学(日语)理学学士
工作经历: 2017.09—现在 吉林大学,生命科学学院,副教授
2012.11—2017.09 吉林大学,生命科学学院,讲师
2010.08—2012.08 吉林大学,生命科学学院,博士后
科研项目: 承担项目
1. 横向课题:鲨烯纳米乳佐剂及佐剂流感疫苗的开发,100万元,项目负责人。
2. 吉林省产业技术创新战略联盟项目子课题:新型疫苗佐剂研究(资助编号:20140309007YY-02;执行年限:2015.1-2017.12),25万元,项目负责人。
3.十二五重大传染病科技专项子课题项目:DNA疫苗生产工艺研究(资助编号:2012ZX10001-009-06;执行年限2012.6-2015.12),40万元,项目负责人。
4. 吉林大学中央高校基本科研业务费项目:Zein/PLGA微粒载体用于化学修饰艾塞那肽跨细胞传递研究(执行年限:2013.01-2014.12),5万元,项目负责人。
5. 省自然科学基金项目:功能化壳聚糖/PLGA纳米粒用于化学修饰胸腺五肽口服传递研究(资助编号:C2011319001;执行年限:2011.1—2013.12),10万元,项目负责人。
6. 中国博士后科学基金面上项目:化学修饰免疫调节剂胸腺五肽/壳聚糖-EDTA-bestatin纳米粒口服传递研究(资助编号:20110491321;执行年限:2011.1—2012.8),3万元,项目负责人。
参与项目
1. 国家自然科学基金-英国皇家学会国际合作项目:单相溶液冻干技术制备蛋白多肽药物传递载体及载体的表征和应用(资助编号:30711130240;执行年限:2007.4—2008.12),主要完成人。
2. 国家自然科学基金面上项目: 甘露糖修饰胆盐多囊脂质体口服疫苗传递系统(资助编号:30672555;执行年限:2007.1—2009.12),主要参加人
学术论文: Selected Publications:
1. Shi W, Kou YM, Xiao JH, Zhang LJ, Gao F, Kong W, Su WH, Jiang CL*, Zhang Y*. Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants. Vaccine. 2018, In press.
2. Li F, Chen Y, Liu SB, Qi J, Wang WY, Wang CH, Zhong RY, Chen ZJ, Li XM, Guan YZ, Kong W, Zhang Y*. Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate. Int. J. Nanomedicine. 2017,12: 8197—8209.
3. Feng J, Chen Y, Li F, Cui LL, Shi NQ, Kong W, Zhang Y*. Synthesis, Characterization and In Vitro Evaluation of a Novel Glycol Chitosan-EDTA Conjugate to Inhibit Aminopeptidase-Mediated Degradation of Thymopoietin Oligopeptides. Molecules. 2017, 22(8): 1253.
4. Zhang Y*, Cui LL, Li F, Shi NQ, Li CL, Yu XH, Chen Y*, Kong W. Design, fabrication and biomedical applications of zein-based nano/micro-carrier systems. Int J Pharm. 2016,513(1-2):191-210.
5. Zhang Y*, Feng J, Cui LL, Zhang YB, Li WZ, Li CL, Shi NQ, Chen Y*, Kong W. Investigation into efficiency of a novel glycol chitosan-bestatin conjugate to protect thymopoietin oligopeptides from enzymatic degradation. J Pharm. Sci.(Ronald T. Borchardt Dedicated Issue) 2016,105(2): 828-837.
6. Sun YN, Wang MS, Sun BX, Li F, Liu SB, Zhang Y*, Zhou Y, Chen Y*, Kong W.An investigation into the gastrointestinal stability of exenatide in the presence of pure enzymes, everted intestinal rings and intestinal homogenates. Biol Pharm Bull. 2016,39(1):42-48.
7. Zhang Y*, Cui LL, Chen Y, Zhang H, Zhong J, Sun YN, Shi NQ, Li CL, Kong W*. Zein-based nanofibres for drug delivery: Classes and current applications. Curr Pharm Des. 2015,21(22):3199-3207.
8. Zhang Y*, Cui LL, Che XX, Zhang H, Shi NQ, Li CL, Chen Y*, Kong W. Zein-based films and their usage for controlled delivery: Origin, classes and current landscape. J Control Release. 2015,206:206-217.
9. Shi NQ*, Qi XR*, Xiang B, Zhang Y. A survey on “Trojan Horse” peptides: Opportunities, issues and controlled entry to "Troy". J Control Release. 2014,194:53-70.
10. Wang MS, Zhang Y, Sun BX, Sun YN, Gong X, Wu YG, Zhang XZ, Kong W*, Chen Y*. Permeability of Exendin-4-Loaded Chitosan Nanoparticles across MDCK Cell Monolayers and Rat Small Intestine. Biol Pharm Bull. 2014,37(5):740-747.
11. Wang MS, Zhang Y, Feng J, Gu TJ, Dong QG, Yang X, Sun YN, Wu YG, Chen Y*, Kong W*. Preparation, characterization, and in vitro and in vivo investigation of chitosan-coated poly (d,l-lactide-co-glycolide) nanoparticles for intestinal delivery of exendin-4. Int. J. Nanomedicine. 2013,8:1141-54.
12. Dong QG, Zhang Y, Wang MS, Feng J, Zhang HH, Wu YG, Gu TJ, Yu XH, Jiang CL, Chen Y*, Li W, Kong W*. Improvement of enzymatic stability and intestinal permeability of deuterohemin-peptide conjugates by specific multi-site N-methylation. Amino Acids. 2012,43(6):2431-41.
13. Wang MS, Sun BX, Feng J, Zhang HH, Liu B, Li C, Chen Y*, Zhang Y*, Kong W. Investigation of transport mechanism of exendin-4 across MDCK cell monolayers. Biol. Pharm. Bull. 2012,35(5):745-52.
14. Zhang Y*, Deng YJ, Wang XL, Xu JH, Li ZQ*. Conformational and bioactivity analysis of insulin: freeze-drying TBA/water co-solvent system in the presence of surfactant and sugar. Int. J. Pharm. 2009,371(1-2):71-81.
15. Zhang Y, Deng YJ*, Lu M, Duncan Q.M. Craig, Li ZQ*. A spectroscopic investigation into interaction between bile salts and insulin in alkaline aqueous solution. J. Colloid Interface Sci. 2009,337(2):322-331.
16. Hao AJ, Deng YJ*, Li TF, Suo XB, Cao YH, Hao YL, Zhang Y. Degradation kinetics of fluorouracil-acetic-acid-dextran conjugate in aqueous solution. Drug Dev. Ind. Pharm. 2006,32(6):757-63.
17. Hao YL, Deng YJ*, Chen Y, Wang KZ, Hao AJ, Zhang Y. In-vitro cytotoxicity, in-vivo biodistribution and antitumor effect of PEGylated liposomal topotecan. J. Pharm. Pharmacol. 2005,57: 1279-1287.

专利
1. 张勇,陈妍,孔维。苯丁抑制素乙二醇壳聚糖及其制备方法(专利号201410260315.x)
着作教材: 1. 第十七章 脂质体在其他给药系统中的应用.《脂质体技术》(主编:邓英杰,书号:ISBN:978-7-117-08409-3/R.8410),人民卫生出版社,2007。
2. Zhang Y*, Cui LL, Chen Y and Kong W. Chapter 1: Exendin-4 and Its Derivatives for Diabetes and Obesity: Old Story and New Hope, in Ed, Atta-ur-Rahman, Frontiers in Clinical Drug Research- Diabetes and Obesity, Bentham Science Publishers, 2016, volume 3, page: 3-58. ISBN: 978-1-68108-248-6.

获奖情况: 第五届吉林省大学生生命科学创新实验大赛 省级二等奖 2017.05 (董志颖 王心蕊 赵妍 王兆琦)

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