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师资队伍
滕乐生
基本情况
姓名: 滕乐生
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
电话:
Email:
详细情况
所研究方向: 药物传递系统
教育经历: 2009.9- 2012.6, 吉林大学生命科学学院 博士学位
2010.9 - 2012.5, Ohio State University College of Pharmacy 联合培养
2007.9 - 2009.9, 吉林大学生命科学学院 硕博连读
2007.1 - 2007.7, 沈阳药科大学 联合培养
2003.9 - 2007.7, 吉林大学生命科学学院 本科学位
工作经历: 2012.6-2013.9吉林大学生命科学学院 讲师
2013.10-2015.09吉林大学生命科学学院 副教授
2015.10-至今吉林大学生命科学学院 教授
科研项目: 1. 国家自然科学基金青年项目,基于微流控芯片技术制备多功能靶向siRNA脂质纳米粒及其合成机制的研究(81502999),2016/01-2018/12,21万元,主持人;
2.吉林省“双十工程”重大科技成果转化项目,20140301003YY,小牛脾提取物注射液技术提升与成果产业化,2014/01-2016/12,100万元,主持人;
3.企业合作项目,林蛙多肽喷雾剂和凝胶剂的研发(3R112J871413),2012/08-2014/12,100万元,主持人;
4.吉林省科技厅,用于治疗精神疾病的新颖化合物及其制备方法,(3D513R301413),2013/01-2015/12,50万元,主持人;
5.企业合作,新型靶向非病毒阳离子基因载体的研究与开发(3R113AF61413),2013/09-2015/08,20万元,主持人;
6.吉林省发展与改革委员会项目,2013779,多西他赛白蛋白纳米粒的研发,2012/01-2014/12,10万元,主持人;
7.吉林省科技厅,新型靶向非病毒阳离子基因载体的研究与开发(3D513R301413),2013/01-2015/12,3万元,主持人;
学术论文: FULL-LENGTH ORIGINAL RESEARCH ARTICLES
1. Jing Xie, Zhaogang Yang, Chenguang Zhou, Jing Zhu, Lee J. Robert, Lesheng Teng. Nanotechnology for the delivery of phytochemicals in cancer therapy. Biotechnology advances. 2016,34(3)343-353. PMID:27071534
2. Jing Xie, Xiaomin Zhang, Meiyu Teng, Bo Yu, Shuang Yang, Robert J. Lee, Lesheng Teng. Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy. International Journal of Nanomedicine. 2016,11,1677-1686
3. Wang, Di, Zhang Yongfeng, Lu Jiahui, Wang Yang, Wang Junyue, Meng, Qingfan, Lee, Robert J, Wang, Di, Teng, Lesheng. Cordycepin, a Natural Antineoplastic Agent, Induces Apoptosis of Breast Cancer Cells via Caspase-dependent Pathways. Natural product communications. 2016,11(1):63-68. PMID:26996021
4. Liu Yan, Lu Chengyu, Meng Qingfan, Lu Jiahui, Fu Yao, Liu Botong, Zhou Yongcan, Guo Weiliang, Teng Lesheng.Near infrared spectroscopy coupled with radial basis function neural network for at-line monitoring of Lactococcus lactis subsp. fermentation. Saudi journal of biological sciences. 2016 Jan;23(1):S106-12. PMID:26858554
5. Du, Linna, Liu, Chungang, Teng, Meiyu, Meng, Qingfan,Lu Jiahui, (Zhou, Yulin, Liu Yan, Cheng Yingkun, Wang, Di, Teng, Lesheng. Anti-diabetic activities of Paecilomyces tenuipes N45 extract in alloxan-induced diabetic mice. Molecular medicine reports. 2016, 13(2):1701-1708. PMID:26718133
6. Wang, Juan, Song, Jingjing, Wang, Di, Zhang, Na, Lu, Jiahui, Meng, Qingfan, Zhou, Yulin, Wang, Ning, Liu, Yang, Wang, Di, Teng, Lesheng. The anti-membranous glomerulonephritic activity of purified polysaccharides from Irpex lacteus Fr. International journal of biological macromolecules. 2016,84:87-93. PMID:26656595
7. Song Jia, Xing, Gaoyang, Cao Jiaming, Teng Lirong, Li Chenliang, Meng, Qingfan, Lu Jiahui, Zhou Yulin, Liu Yang, Wang Di, Teng Lesheng. Investigation of the antidepressant effects of exopolysaccharides obtained from Marasmiusandrosaceus fermentation in a mouse model. Molecular medicine reports. 2016,13(1):939-946. PMID: 26648283
8. Bin Zheng, Shuang Yang, Chunyu Fan, Ye Bi, Lin Du, Lingzhi Zhao, Robert J.Lee, Lesheng Teng, Lirong Teng, Jing Xie. Oleic acid derivative of polyethyleniminefunctionalized proliposomes for enhancing oral bioavailability of extract of Ginkgo biloba Drug Delivery. 2015 Dec 3:1-10. PMID: 26635185
9. Yu Kongtong, Zhao, Jinlong, Zhang, Zunkai, Gao Yin), Zhou Yulin, Teng Lesheng, Li Youxin. Enhanced delivery of Paclitaxel using electrostatically conjugated Herceptin-bearing PEI/PLGA nanoparticles against HER-positive breast cancer cells. International journal of pharmaceutics. 2015, 497(1-2):78-87. PMID: 26617314
10. Li Yuhuan, Li Yujing, Lee Robert J., Wang Xi, Du Lin, Zhao Lingzhi, Liu, Yan, Teng Lesheng. Antitumor activity of a novel survivin siRNA. Pakistan Journal of Pharmaceutical Sciences.2015,28(5):1887-1890. PMID: 26525031
11. Li Yuhuan, Liu Da, Zhou Yulin, Li Yujing, Xie Jing, Lee Robert J. Cai Yong, Teng Lesheng. Silencing of Survivin Expression Leads to Reduced Proliferation and Cell Cycle Arrest in Cancer Cells. Journal of cancer . 2015, 6(11):1187-1194. PMID:26516368
12. Zheng Bin, Yang Shuang, Wang Mengqiao, Yang Xuewei, Teng Lirong, Xie Jing, Teng Lesheng, Lee Robert J. Non-covalent Nanocomplexes of Folic Acid and Reducible Polyethylenimine for Survivin siRNA Delivery. Anticancer research .2015,35(10):5433-5441.PMID:2640870
13. Li Yuhuan, Li Yujing, Wang Xinmei, Lee Robert J., Teng Lesheng. Fatty acid modified octa-arginine for delivery of siRNA. International journal of pharmaceutics. 2015 495(1):527-535. PMID: 26386137
14. Song, Jingjing Wang Yingwu, Teng, Meiyu, Cai, Guangsheng, Xu, Hongkai, Guo, Hanxiao, Liu, Yang, Wang, Di, Teng, Lesheng. Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-based complementary and alternative medicine : eCAM. 2015, 2015:174616. PMID:26351509
15. Yang, Xuewei, Yang, Shuang, Chai, Hongyu, Yang, Zhaogang, Lee, Robert J., Liao, Weiwei, Teng, Lesheng. A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells UsingTransferrin-Conjugated Liposomes. Plos one. 2015, 10(8),e0136649.PMID:26309138
16. Wang, Chenhui, Yu, Changhui, Liu, Jiaxin,Sun, Fengying, Teng, Lesheng, Li, Youxin.Stabilization of Human Immunoglobulin G Encapsulated within Biodegradable Poly (Cyclohexane-1, 4-diyl Acetone Dimethylene Ketal) (PCADK)/ Poly (Lactic-co-Glycolic Acid) (PLGA) Blend Microspheres. Protein and peptide letters. 2015,22(11):963-971. PMID:26268563
17. Shuang Yang, Xuewei Yang, Yan Liu, Bin Zheng, Lingjun Meng, Robert J. Lee, Jing Xie, Lesheng Teng. Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisenseoligonucleotide delivery, Colloids and Surfaces B: Biointerfaces. 2015,135 (2015): 274-282. PMID: 26263216
18. Dai Wenwen, Wang Chenhui, Yu Changhui, Yao Ju) Sun Fengying, Teng Lesheng, Li, Youxin. Preparation of a mixed-matrix hydrogel of vorinostat for topical administration on the rats asexperimental model. European journal of pharmaceutical sciences.2015, 78:255-263. PMID:26248300
19. Du Linna, Liu Yan, Liu Chungang, Meng Qingfan, Song Jingjing, WangDi, Lu Jiahui, Teng Lirong, Zhou Yulin, Teng Lesheng. Acute and Subchronic Toxicity Studies on Safety Assessment of Paecilomyces tenuipes N45Extracts. Combinatorial chemistry & high throughput screening. 2015,18(8):809-818. PMID:26234509
20. Zheng Bin, Teng Lirong, Xing Gaoyang, BiYe, Yang Shuang,Hao Fei,Yan Guodong, Wang Xinmei, Lee Robert J.,Teng Lesheng, Xie Jing. Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: Formulationoptimization, characterization, oral bioavailability and tissue distribution in rats. European journal of pharmaceutical sciences.2015, 77:254-264. PMID:26116277
21. Shuang Yang, Zhihua Guo, Xuewei Yang, Jing Xie, Robert J. Lee, Dan Jiang, Lesheng Teng. Enhanced survivin siRNA delivery using cationic liposome incorporating fatty acid-modified polyethylenimine. Chem. Res. Chin. Univ.,2015, 31(3): 401-405.
22. Shuang Yang, Lee J. Robert, Xuewei Yang, Bin Zheng, Jing Xie, Lingjun Meng, Yan Liu,Lesheng Teng.A novel reduction-sensitive modified polyethylenimine oligonucleotide vector. International Journal of Pharmaceutics..2015, 484(1-2):44-50. PMID: 25698089
23. Yanbin Sun, Bo Yu, Guoying Wang, Yongsheng Wu, Xiaomin Zhang, Tianyou Wang, Suoqing Tang, Yuan Yuan, Lesheng Teng, and Shun Xu. Enhanced antitumor efficacy of vitamin E TPGS-emulsified PLGA nanoparticles for delivery of paclitaxel. Colloids Surf B Biointerfaces .2014,123(1):716-723.PMID: 25456995
24. Chenguang Zhou, Zhaogang Yang, Lesheng Teng. Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives. Curr Pharm Biotechnol. 2014;15(9):829-38.PMID: 25335533
25. Yang, Zhaogang; Yu, Bo; Zhu, Jing; Huang, Xiaomeng; Xie, Jing; Xu, Songlin; Yang, Xiaojuan; Wang, Xinmei; Yung, Bryant C; Lee, L James, Robert J. Lee Lesheng Teng. A microfluidic method to synthesize transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia. Nanoscale. 2014, 6(16):9742-51.PMID: 25003978
26. Jia Song, Jing Xie, Chenliang Li, Jia-hui Lu, Qing-fan Meng, Zhaogang Yang, Robert J. Lee, Di Wang, Le-sheng Teng. Near infrared spectroscopic (NIRS) analysis of drug-loading rate and particle size of risperidone microspheres by improved chemometric model. International Journal of Pharmaceutics.2014, 472 :296–303. PMID: 24954726
27. Bo Yu. Xinmei Wang. Chenguang Zhou. Lesheng Teng. Wei Ren. Zhaogang Yang. Chih-Hsin Shih. Tianyou Wang. Robert J. Lee. Suoqin Tang. L. James Lee. Insight into Mechanisms of Cellular Uptake of Lipid Nanoparticles and Intracellular Release of Small RNAs. Pharmaceutical Research. 2014, 1366-7.PMID: 24740244
28. Teng, Lesheng; Kou, Chunjia; Lu, Chengyu; Xu, Jiaming; Xie, Jing; Lu, Jiahui; Liu, Yan; Wang, Zhenzuo; Wang, Di. Involvement of the ERK pathway in the protective effects of glycyrrhizic acid against the MPP+-induced apoptosis of dopaminergic neuronal cells. International journal of molecular medicine.2014, 34(8):742-8.PMID: 24993693.
29. Ximing Liu, Lu Fu, Wenwen Dai, Wei Liu,Jinlong Zhao, Yi Wu, Lengsheng Teng, Fengying Sun, Youxin Li. Design of transparent film-forming hydrogels of tolterodine and their effects on stratum corneum. International Journal of Pharmaceutics. 2014, 471:322-331. PMID: 24882035
30. Dan Wang, Jinlong Zhao, Ximing Liu, Fengying Sun, Yulin Zhou, Lesheng Teng, Youxin Li. Parenteral thermo-sensitive organogel for schizophrenia therapy,in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences.2014, 60:40–48.PMID: 24815944
31. Lesheng Teng, Qingfan Meng, Jiahui Lu, Jing Xie, Zhenzuo Wang, Yan Liu, Di Wang. Liquiritin modulates ERK and AKT/GSK 3β dependent pathways to protect against glutamate induced cell damage in differentiated PC12 cells. Molecular medicine reports. 2014, 10:818-824.PMID: 24888902
32. Wang, Di; Lu, Jiahui; Liu, Yan; Meng, Qingfan; Xie, Jing; Wang, Zhenzuo; Teng, Lesheng. Liquiritigenin induces tumor cell death through mitogen-activated protein kinase- (MPAKs-) mediated pathway in hepatocellular carcinoma cells. BioMed research international. 2014, 2014:965316.PMID: 24738081
33. Jing Xie, Xin Li, Chaojun Jiang, Robert J Lee,Yulin Zhou, Lesheng Teng. Novel PLGA microspheres for sustained delivery of antisense oligonucleotide . Chemical Research in Chinese Universites.2013, 29 (5):1003-1005.
34. Orapan Paecharoenchai, , Lesheng Teng, Bryant C Yung, Lirong Teng, Praneet Opanasopit, Robert J Lee. Nonionic surfactant vesicles for delivery of RNAi therapeutics. Nanomedicine.2013, 8(11):1865-1873. PMID: 24156490
35. .Huan Yu, Lirong Teng, Qingfan Meng, Yuhuan Li, Xiaocheng Sun, Jiahui Lu, Robert J Lee, Lesheng Teng. Development of liposomal Ginsenoside Rg3: Formulation optimization and evaluation of its anticancer effects. International Journal of Pharmaceutics.2013, 450 (1-2): 250-258. PMID: 23628402
36. Lesheng Teng, Chaojun Jiang, Fengying Sun, Chunmei Li, Lirong Teng, Qingfan Meng, Robert J Lee, Youxin Li. Long-acting formulation of a new muscarinic receptor antagonist for the treatment of overactive bladder. Journal of Microencapsulation.2013, 30 (2): 116-123. PMID: 22861176
37. Longzhu Piao, Hong Li, Lesheng Teng, Bryant C Yung, Yasuro Sugimoto, Robert W Brueggemeier, Robert J Lee. Human serum albumin-coated lipid nanoparticles for delivery of siRNA to breast cancer. Nanomedicine: nanotechnology, biology, and medicine.2013, 9 (1): 122-129. PMID: 22542825
38. Jing Xie, Lesheng Teng, Zhaogang Yang, Chenguang Zhou, Liu Yang, Bryant C Yung, Robert J Lee. A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery. BioMed research international. 2013, 2013:710502. PMID: 23862153
39. Lesheng Teng, Jing Xie, Lirong Teng, Robert J Lee. Enhanced siRNA delivery using oleic acid derivative of polyethylenimine. Anticancer Research.2012, 32 (4): 1267-1271. PMID: 22493358
40. Lesheng Teng, Jing Xie, Lirong Teng, Robert J Lee. Clinical translation of folate receptor-targeted therapeutics. Expert Opinion on Drug Delivery.2012, 9 (8): 901-908. PMID: 22663189
41. Bo Yu, Shu-Hao Hsu, Chenguang Zhou, Xinmei Wang, Megan C Terp, Yun Wu, Lesheng Teng, Yicheng Mao, Feng Wang, Weiming Xue, Samson T Jacob, Kalpana Ghoshal, Robert J Lee, Ly J Lee. Lipid nanoparticles for hepatic delivery of small interfering RNA. Biomaterials.2012, 33(25): 5924-5934. PMID: 22652024
42. Ying Liu, Songlin Xu, Lesheng Teng, Bryant Yung, Jing Zhu, Hong Ding, Robert J Lee. Synthesis and evaluation of a novel lipophilic folate receptor targeting ligand. Anticancer Research.2011, 31 (5): 1521-1525. PMID: 21617205
43. Zhengxing Su, Yanan Shi, Lesheng Teng, Xiang Li, Lexi Wang, Qingfan Meng, Lirong Teng and Youxin Li. Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) microspheres for sustained release of risperidone: zero-order release formulation. Pharmaceutical Development and Technology.2011, 16 (4): 377-384. PMID: 20370594
44. Lesheng Teng, Chaojun Jiang, Xiangyou Lin, Yuanchen Dong, Chunmei Li, Qingfan Meng, and Youxin Li. Preparation of tolterodine metabolite loaded biodegradable PLGA microsphere. Chemical Research in Chinese Universites.2010, 26 (1): 75-80.
45. Fengying Sun, Cheng Sui, Lesheng Teng, Ximing Liu, Lirong Teng, Qingfan Meng, Youxin Li. Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres. International Journal of Pharmaceutics.2010, 397 (1): 44-49. PMID: 20600717
46. Lesheng Teng, Di Wang, Jia Song, Yibo Zhang, Weiliang Guo, Lirong Teng. Application of near infrared spectroscopy in rapid and simultaneous determination of essential components in five varieties of anti-tuberculosis tablets. Spectroscopy and Spectral Analysis. 2008, 28 (8): 1814-1817.
47. Qingfan Meng, Lesheng Teng, Chaojun Jiang, Jinshuang An, Lei Li, Jiahui Lu and Lirong Teng. First-order derivative spectrophotometry for thedetermination of vitamin C in medicament. Chemical Research in Chinese Universites.2008, 24 (1): 29-31.
48. Guosheng Teng, Lesheng Teng, Yi Wu, Yunbiao Tang, Lanying Liu and Jingkai Gu. A rapid and sensitive LC-MS/MS method for the quantification of fexofenadine in human plasma: Application to a bioequivalence study in Chinese volunteers. Chemical Research in Chinese Universites.2007, 23 (5): 514-517.
Recent Abstracts

1. Shuang Yang , Xuewei Yang , Jing Xie , Robert J. Lee, Lesheng Teng.Enhanced survivin siRNA delivery using cationic liposomes containing linoleic acid-modified polyethylenimine. Nanomedicine: Nanotechnology, Biology and Medicine.12(2):503
2. Shuang Yang , Xuewei Yang , Jing Xie , Robert J. Lee, Lesheng Teng.Efficient antisense oligonucleotide delivery via non-covalent complexes of folic acid and modi?ed polyethylenimine. Journal of Controlled Release.182(1)163. 3nd Symposium on Innovative Polymers for Controlled Delivery.
3. Lesheng Teng, Oligonucleotide Delivery System. 2014;15(9):779.PMID: 25403515
4. Zheng, Bin, Yang, Shuang, Teng, Lesheng, Lee, Robert J., Xie, Jing. Enhanced oral bioavailability of the ginkgo biloba leaf extract (egb761) in proliposomes containing a bile salt. Journal of investigative medicine.2014, 62(8):S91-S92. 2nd International Conference on Biomedicine and Pharmaceutics (ICBP).
5. Xie, Jing; Teng, Lesheng; Lu Jiahui; Lee, Robert J. Novel microspheres for controlled release ofoligonucleotides. Journal of investigative medicine.62(1):252-252. Western Regional Meeting of the American-Federation-for-Medical-Research, JAN 2014 , Carmel, CA.
6. Lesheng Teng, Huan Yu, Yingkun Cheng, Wei Meng, Jiahui Lu. Enhanced bioavailability of nifedipine by self-microemulsifying drug delivery system. Journal of Investigative Medicine. Journal of Investigative Medicine. 61(4)S14-14. International Conference on Biomedicine and Pharmacology (ICBP).Apr, 2013, Beijing, China.
7. Teng, Lesheng; Xie, Jing; Lee, Robert J. A novel reducible cationic siRNA delivery agent for liver cancer with an ehanced intracellular release mechanism. Hepatology,58(S1):405A-405A. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases. NOV 01-05, 2013 Washington, DC
8. Yujing Li, Jiahui Lu, Huiqin Liu, Na Qu, Xiaojun Peng, Lesheng Teng. Liposome formulations with strengthened stability in storage and enhanced antimicrobial activity. Journal of Investigative Medicine. 61(4) S15-16. International Conference on Biomedicine and Pharmacology (ICBP).Apr, 2013, Beijing, China.
9. Jing Xie, Robert J Lee, Lesheng Teng. A novel controlled release PLGA microspheres for the antisense oligonucleotide. 40th CRS Annual Meeting & Exposition. 2013.38(1):263.
10. Lesheng. Teng, Chaojun. Jiang, Xiaozheng. Shi, Renyu. Zhang, Youxin. Li. Preparation of Biodegradable poly D, L-lactide-co-glycolide (PLGA) microspheres for tolterodine derivative. 38th CRS Annual Meeting & Exposition. 2011.38(1):618.
11. Chaojun Jiang, Lesheng Teng, Lirong Teng, Chunmei Li, Youxin Li. A novel controlled release PLGA microspheres for the antisense oligonucleotide. Biodegradable PLGA Microsphere for the controlled release of tolterodine derivative. Journal of Biotechnology. 2008, 36 (1): S416-S417.

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