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于彬
基本情况
姓名: 于彬
性别:
职称: 副教授
最高学历: 研究生
最高学位: 博士
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详细情况
所在学科专业: 微生物学
所研究方向: 1、腺病毒载体装配及免疫机制研究;2、新型靶向性溶瘤腺病毒载体设计;3、新型脑靶向病毒载体设计;4、艾滋病黏膜疫苗设计
讲授课程: 分子生物学;分子病毒学;免疫学实验
教育经历: 2006/09 - 2012/06,吉林大学,微生物学,博士
2002/09 - 2006/06,吉林大学,制药工程,学士
工作经历: 2014/10 - 至今,吉林大学,生命科学学院,副教授
2012/10 - 2016/06,中科院长春应化所,博士后
2012/07 - 2014/09,吉林大学,生命科学学院,讲师
科研项目: 1、国家自然科学基金面上项目,81673002,新型双级脑靶向溶瘤腺病毒载体设计及其治疗恶性胶质瘤的研究,2017/01-2020/12,58万元,在研,主持
2、吉林省科技发展计划自然科学基金,20160101240JC,重组8型腺相关病毒载体介导CDNF和AADC联合治疗帕金森病大鼠模型的实验研究,2016/01-2018/12,10万元,在研,主持
3、国家自然科学基金面上项目,81472816,衣壳蛋白基因修饰溶瘤腺病毒基因治疗载体的设计和治疗恶性肿瘤的研究,2015/01-2018/12,72万元,在研,参加
4、国家科技重大专项子课题,2014ZX09304314-001-02,以survivin和MUC1为靶点肿瘤治疗性基因疫苗的有效性研究,2015/01-2016/12,30万元,在研,主持
5、国家自然科学基金青年科学基金项目,31300756,腺病毒衣壳蛋白特异性中和抗体性质及血清型特异中和抗原确认的研究,2014/01-2016/12,23万元,在研,主持
6、吉林省科技发展计划青年科研基金项目,20140520007JH,新型基因工程修饰重组TRAIL蛋白联合奥沙利铂治疗原发性肝癌的研究,2014/01-2016/12,5万元,在研,主持
7、中国博士后科学基金第七批特别资助,2014年,15万元,生物工程
8、国家科技重大专项子课题,2012ZX10001-009-13,多肽-重组流感疫苗Ⅰ期临床样本检测,2013/06-2015/05,50万元,已结题,主持
9、国家自然科学基金面上项目,31071131,人Ino80染色质重塑酶的结构及其转录功能的研究,2011/01-2013/12,37万元,已结题,参加
10、国家自然科学基金面上项目,30872396,六邻体嵌合型rAd5载体逃避机体预存免疫的机制,2009/01-2011/12,35万元,已结题,参加
学术论文: 近5年通讯和第一作者文章:
1. Jingyi Yan, Lizheng Wang, Zixuan Wang, Zhen Wang, Baoming Wang, Rui Zhu, Jinpeng Bi, Jiaxin Wu, Haihong Zhang, Hui Wu, Bin Yu*, Wei Kong, Xianghui Yu*. Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity. Cell Death and Disease, 2016, Jun, 7(6):e2274.
2. Lizheng Wang, Zixuan Wang, Fangfang Zhang, Rui Zhu, Jinpeng Bi, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*. Enhancing Transgene Expression from Recombinant AAV8 Vectors in Different Tissues Using Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element. International Journal of Medical Sciences. 13(4): 286-291 (2016)
3. Jingyi Yan#, Jianing Dong#, Jiaxin Wu, Rui Zhu, Zhen Wang, Baoming Wang, Lizheng Wang, Zixuan Wang, Haihong Zhang, Hui Wu, Bin Yu*, Wei Kong & Xianghui Yu*. Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors. Scientific Reports. 6:22464 (2016)
4. Shuai Lang, Lizheng Wang, Zixuan Wang, Rui Zhu, Jingyi Yan, Baoming Wang, Jiaxin Wu, Haihong Zhang, Hui Wu, Yan Zhou, Wei Kong, Bin Yu* and Xianghui Yu*. Localization of neutralization epitopes on adenovirus fiber knob from species C. Journal of General Virology. 97: 955-962 (2016)
5. Baoming Wang, Zhen Wang, Jingyi Yan, Lizheng Wang, Zixuan Wang, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*. Expression, purification and characterization of heterotrimeric forms of sTRAIL using a polycistronic expression vector. Protein Expression and Purification. 115: 118-124 (2015)
6. Zhen Wang, Baoming Wang, Junfang Lou, Jingyi Yan, Lei Gao, Ranshen Geng, Bin Yu*. Mutation in fiber of adenovirus serotype 5 gene therapy vector decreases liver tropism. Int J Clin Exp Med. 7(12): 4942-4950 (2014)
7. Zhen Wang#, Bin Yu#, Baoming Wang, Jingyi Yan, Xiao Feng, Zixuan Wang, Lizheng Wang, Haihong Zhang, Hui Wu, Jiaxin Wu, Wei Kong, Xianghui Yu. A novel capsid-modified oncolytic recombinant adenovirus type 5 for tumor-targeting gene therapy by intravenous route. Oncotarget, 2016, Jun, doi: 10.18632/oncotarget.10075
8. Bin Yu, Jianing Dong, Chu Wang, Zhen Wang, Lei Gao, Haihong Zhang, Jiaxin Wu, Wei Kong* and Xianghui Yu*. Trimeric knob protein specifically distinguishes neutralizing antibodies to different human adenovirus species: potential application for adenovirus seroepidemiology. Journal of General Virology. 95: 1564–1573 (2014)
9. Bin Yu, Jianing Dong, Chu Wang, Yang Zhan, Haihong Zhang, Jiaxin Wu, Wei Kong*, Xianghui Yu*. Characteristics of neutralizing antibodies to adenovirus capsid proteins in human and animal sera. Virology 437: 118–123 (2013)
10. Bin Yu, Zhen Wang, Jianing Dong, Chu Wang, Lina Gu, Caijun Sun, Wei Kong*, Xianghui Yu*. A serological survey of human adenovirus serotype 2 and 5 circulating pediatric populations in Changchun, China, year of 2011. Virology Journal 9: 287 (2012)
11. Bin Yu, Yan Zhou, Hao Wu, Zhen Wang, Yang Zhan, Xiao Feng, Ranshen Geng, Yongge Wu, Wei Kong* and Xianghui Yu*. Seroprevalence of neutralizing antibodies to human adenovirus type 5 in healthy adults in China. Journal of Medical Virology 84: 1408–1414 (2012)
12. Bin Yu, Chu Wang, Jianing Dong, Min Zhang, Haihong Zhang, Jiaxin Wu, Yuqing Wu, Wei Kong* and Xianghui Yu*. Chimeric hexon HVRs protein reflects partial function of adenovirus. Biochem. Biophys. Res. Commun. 421: 170-176 (2012)
13. Bin Yu#, Yu Zhang#, Yang Zhan, Xiao Zha, Yongge Wu, Xizhen Zhang, Qingzhe Dong, Wei Kong*, Xianghui Yu*. Co-expression of herpes simplex virus thymidine kinase and Escherichia coli nitroreductase by an hTERT-driven adenovirus vector in breast cancer cells results in additive anti-tumor effects. Oncology Reports 26: 255-264 (2011)
着作教材: 《基因工程原理与技术》,高教出版社,参编

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