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付学奇
基本情况
姓名: 付学奇
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
电话:
Email:
详细情况
所在学科专业: 生物化学与分子生物学
所研究方向: 蛋白质酪氨酸磷酸酶和激酶的结构与功能的研究及抑制剂的筛选,揭示酪氨酸磷酸酶和激酶的异常与人类重大疾病的发生、发展之间的关系。
教育经历: 1979.09-1984.07吉林大学/化学/本科/学士
1988.09-1991.06吉林大学/生物化学/研究生/硕士
1991.09-1994.06吉林大学/化学/研究生/博士
工作经历: 1984.07/1988.08/吉林省中医中药研究院/研究实习员
1992.09/1997.08/吉林大学酶工程国家重点实验室/讲师
1994.11/1996.01/白求恩医科大学/基础医学/博士后
1996.01/1997.07/以色列希伯来大学/化学/博士后
1997.09/2001.08/吉林大学分子生物学系/副教授
2001.09/2008.12/吉林大学生命科学学院/系主任/教授
2009.01/现在/吉林大学生命科学学院/副院长/教授
2001.04/2002.03/日本关西学院大学/生命科学/访问学者
2006.09/2007.02/美国俄克拉荷马大学/生命科学/访问学者
2009.09/2009.12/美国俄克拉荷马大学/生命科学/访问学者
2010.11/2010.12/美国俄克拉荷马大学/生命科学/访问学者
科研项目: 近5年,承担10余项科研项目,承担了2项吉林大学高水平研究生课程体系建设项目。
学术论文:
1、期刊论文:
[1]. Wang Z, Xu B, Zhang L, Zhang J, Ma T, Zhang J, Fu X*, Tian W*,Folic acid-functionalized mesoporous silica nanospheres hybridized with AIE luminogens for targeted cancer cell imaging, Nanoscale, 5(5), 2065-2072,2013
[2]. Cao B, Liu X, Li J, Liu S, Qi Y, Xiong Z, Zhang A, Wiese T, Fu X, Gu J, Rennie PS, Sartor O, Lee BR, Ip C, Zhao L, Zhang H, Dong Y*, 20(S)- protopanaxadiol- aglycone downregulation of the full-length and splice variants of androgen receptor, Int J Cancer, 132(6),1277-1287,2013
[3].Li Y, Deng C, Hu X, Patel B, Fu X, Qiu Y, Brand M, Zhao K, Huang S*, Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis, Oncogene, 31 (48), 5007-5008, 2012
[4]. Guo Y, Chen Y, Xu X, Fu X*, Zhao ZJ*,SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells, J Hematol Oncol, 5:72, 2012
[5]. Zhao W, Du Y, Ho WT, Fu X, Zhao ZJ*, JAK2V617F and p53 mutations coexist in erythroleukemia and megakaryoblastic leukemic cell lines, Exp Hematol Oncol, 1(1):15,2012
[6]. Li T, Zeng L, Gao W, Cui MZ, Fu X, Xu X*, PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins,Biochim Biophys Acta,1832(3):453-474, 2013
[7]. Yu X, Ma J, Lin F, Zhao W, Fu X, Zhao ZJ*, Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans,BMC Cell Biol, 13:28, 2012
[8]. Yang T, Jian W, Luo Y, Fu X, Noguchi C, Bungert J, Huang S*, Qiu Y*, Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity,J Biol Chem, 287(48),40279-40291,2012
[9]. Han H, Lu L, Wang Q, Zhu M, Yuan C, Xing S*, Fu X ,Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B,Dalton Trans, 41(36),11116-11124,2012
[10].Chen Y, Guo Y, Han J, Ho WT, Li S, Fu X, Zhao ZJ*,Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity,J Hematol Oncol, 5:39, 2012
[11]. Zeng L, Li T, Xu DC, Liu J, Mao G, Cui MZ, Fu X, Xu X*,Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein,J Biol Chem, 287(34),29125-29133,2012
[12]. Lu L, Gao X, Zhu M*, Wang S, Wu Q, Xing S*, Fu X, Liu Z, Guo M*, Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases,Biometals,25(3),599-610,2012
[13]. Qi Y, Fu X, Xiong Z, Zhang H, Hill SM, Rowan BG, Dong Y* ,Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer, PLoS One, 7(2), 2012
[14]. Wang Q, Zhu M*, Zhu R, Lu L*, Yuan C, Xing S, Fu X*, Mei Y, Hang Q,Exploration of α-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases, Eur J Med Chem, 49,354-364,2012
[15]. Dong B, Zhang Y, Fu X, Wang G*, Absence of JAK2V617F mutation in Chinese deep vein thrombosis patients without myeloproliferative neoplasms, Thromb Res, 129(5), 664-665,2012
[16]. Yuan C, Zhu M*, Wang Q, Lu L, Xing S, Fu X*, Jiang Z, Zhang S, Li Z, Li Z, Zhu R, Ma L, Xu L,Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex, Chem Commun (Camb), 48(8), 1153-1155,2012
[17]. Wang Q, Zhu M*, Lu L*, Yuan C, Xing S, Fu X*, Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization and biological activities, Dalton Trans,40(48),12926-12934,2011
[18]. Yu X, Zhao W, Ma J, Fu X, Zhao ZJ*, Beneficial and harmful effects of alcohol exposure on Caenorhabditis elegans worms, Biochem Biophys Res Commun, 412(4),757-762,2011
[19]. Ma L, Lu L*, Zhu M*, Wang Q, Gao F, Yuan C, Wu Y, Xing S, Fu X*, Mei Y, Gao X, Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases,J Inorg Biochem,105(9),1138-1147,2011
[20]. Li Y, Lu L*, Zhu M*, Wang Q, Yuan C, Xing S, Fu X*, Mei Y, Potent inhibition of protein tyrosine phosphatases by copper complexes with multi- benzimidazole derivatives,Biometals,24(6),993-1004,2011
[21]. Li J, Cao B, Liu X, Fu X, Xiong Z, Chen L, Sartor O, Dong Y, Zhang H*, Berberine suppresses androgen receptor signaling in prostate cancer, Mol Cancer Ther, 10(8), 1346-1356,2011
[22]. Ma L, Lu L*, Zhu M*, Wang Q, Li Y, Xing S, Fu X*, Gao Z, Dong Y, Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5- dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases, Dalton Trans, 40(24),6532-6540,2011
[23]. Ma J, Li Z, Xing S, Ho WT, Fu X*, Zhao ZJ*, Tea contains potent inhibitors of tyrosine phosphatase PTP1B, Biochem Biophys Res Commun, 407(1),98-102, 2011
[24]. Zhao W, Gao R, Lee J, Xing S, Ho WT, Fu X, Li S, Zhao ZJ*,Relevance of JAK2V617F positivity to hematological diseases--survey of samples from a clinical genetics laboratory, J Hematol Oncol, 4:4,2011
[25]. Wang S, Dong H, Han J, Ho WT, Fu X, Zhao ZJ*, Identification of a variant form of tyrosine phosphatase LYP, BMC Mol Biol, 11:78,2010
[26]. Wang F, Fu X, Chen X, Chen X, Zhao Y*, Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells, PLoS One, 5(10) ,2010
[27]. Lu L*, Wang S, Zhu M*, Liu Z, Guo M, Xing S, Fu X*, Inhibition protein tyrosine phosphatases by an oxovanadium glutamate complex, Na2[VO(Glu)2(CH3OH)](Glu = glutamate), Biometals, 23(6),1139-1147,2010
[28]. Yuan C, Lu L*, Wu Y, Liu Z, Guo M*, Xing S, Fu X*, Zhu M*,Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives, J InorgBiochem, 104(9), 978-986, 2010
[29]. Jiang Y, Bernard D, Yu Y, Xie Y, Zhang T, Li Y, Burnett JP, Fu X*, Wang S*, Sun D*,Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions, J Biol Chem, 285(27),21023-21036,2010
2.会议论文:
1. Ying Li, Xin Hu, River Ybarra1, Xueqi Fu, Yi Qiu, Keji Zhao, and Suming Huang*, Serine phosphorylation on TAL1 regulates its interaction with histone Demethylase LSD1, Journal of American Society of Hematology, 2009, Dec, Vol.114, No.22(590),New Orleans, 2009
2. Xin Hu, Xingguo Li, Xueqi Fu, Suming Huang*, LSD1-mediated epigenetic modification is required for TAL1 function, Florida Genetics, 2008, Oct 29-30(41), Florida, 2008
获奖情况: 近5年,培养研究生30余名,其中2人获得吉林省优秀博士论文奖。2011年获吉林省自然科学学术成果二等奖;2011年获吉林省生物化学与分子生物学会学术创新奖;2010获年吉林省科技进步一等奖。


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