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杨艳
基本情况
姓名: 杨艳
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
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详细情况
所在学科专业: 药学
所研究方向: 药代动力学、新型药物制剂
讲授课程: 本科生理论课:生物药剂学与药物动力学
本科生实验课:药物分析
研究生课:体内药物分析
教育经历: 1999.9 – 2003.07,本科,吉林大学化学学院
2003.9 – 2006.07,硕士,沈阳药科大学药学院
2006.9 – 2007.09,博士,吉林大学生命科学学院
2007.9 - 2009.12,吉林大学Purdue University联合培养博士
工作经历: 2009.12 – 2010.09,访问学者,Purdue University
2009.12 – 2011.09,讲师,吉林大学生命科学学院
2010.11 - 2012.11,博士后 中国科学院长春应用化学研究所生态环境高分子材料重点实验室
2011.09 - 2014.09,副教授 吉林大学生命科学学院
2014.09 - 现 在,教授 吉林大学生命科学学院
科研项目: 承担的纵向项目:
1. 国家自然科学基金青年基金“具有pH敏感型隐形外壳的共转运抗肿瘤药物与siRNA的超分子组装体的制备与评价”(81102383)负责人。
2. 国家自然科学基金面上项目“基于类风湿性关节炎信号网络的“功能鸡尾酒”型靶向小核酸递释系统的构建与评价”(81473142)负责人。
3. 中国博士后科学基金“HLA-G单克隆抗体靶向型PEI衍生物的制备及介导siRNA转染的研究” (20110491328)负责人。
4. 吉林省青年科研基金“具有pH和还原力双重响应的肿瘤靶向型药物的制备”(201101040)负责人。
5. 中国博士后基金特别资助“智能化抗肿瘤药物与siRNA共传输系统的构建与评价”(2012T50311)负责人。
6. 国家自然科学基金“黄癸固体分散体新型传递体对2型糖尿病治疗作用与机制研究”(81170745)第二负责人。
7. 国家自然科学基金项目(微管靶向型药物的亚细胞水平药代动力学研究 项目编号30973587)申请的主要参与者。
8. 国家自然科学基金项目(七叶皂苷四组分同时给药的代谢机理及相互关系研究 项目编号30772613)申请的主要参与者。
9. 十一五重大科技专项“临床前药物代谢动力学技术平台”(2009ZX09304-003)申请的主要参与者。
10.科技部中俄国际合作专项“多肽肿瘤靶向抗肿瘤药物高分子载体的研究与开发”(2011DFR51090)申请的主要参与者。
学术论文: 发表文章:
1. Hong Cao, Yan Yang*. Biocatalytic synthesis of poly(δ-valerolactone) using a thermophilic esterase from Archaeoglobus fulgidus as catalyst. Int. J. Mol. Sci. 2012, 13: 12232-12241.
2. Yan Yang, Quanshun Li*. Cell-debris self-immobilized thermophilic esterase: a novel biocatalyst for synthesizing aliphatic polyesters. J Control Release (Abstract for SIPCD),2013-Nov-28,172(10), e111.
3. Yan Yang*. A novel thermohilic histone with promising gene transfection efficiency. J Control Release (Abstract for SIPCD), 2013-Nov-28,172(10),e146.
4. Yang Yu, Yan Yang*. Lipase/esterase-catalyzed synthesis of aliphatic polyesters via polycondensation: a review. Process Biochem. 2012, 47: 1027-1036.
5. Yan Yang, Quanshun Li*. Lipase/esterase-catalyzed ring-opening polymerization: a green polymer synthesis technique. Process Biochem. 2011, 46: 1900-1908.
6. Yan Yang, Quanshun Li*. Lipase-catalyzed synthesis of poly(ε-caprolactone) and its solid-state properties characterization. Biocatal. Biotransform. 2011, 16: 1201-1207.
7. Yang Y, Yeo Y*. Mannitol-Guided delivery of ciprofloxacin in artificial cystic fibrosis mucus model. Biotechnol. Bioeng. 2011, 108: 1441-1449.
8. Zhang, ML, Yang, Y*. Simultaneous Determination of Escin Ia and Its Isomer Isoescin Ia by LC-MS-MS: Application to a Pharmacokinetic Study of Escin Ia in Rats. Chromatographia, 2011, 74: 243-250.
9. Yang, Y., Yeo, Y*. Inhalable antibiotic delivery using a dry powder co-delivering recombinant deoxyribonuclease and ciprofloxacin for treatment of cystic fibrosis. Pharm. Res, 2010, 27: 151-160.
10. Yang, Y., Yeo, Y*. Development of highly porous large PLGA microparticles for pulmonary drug delivery. Biomaterials, 2009, 30: 1947-1953.
11. Yan Yang, Jingkai Gu*. Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry. J. Chromatogr. B 2008, 862: 119-124.
12. Wang T, Ma W, Sun Y, Yang Y, Zhang W, Fawcett JP, Du H, Gu J. Ultra-sensitive assay for paclitaxel in intracellular compartments of A549 cells using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2013, 912:93-7.
13. Basma Ibrahim, Michael Tsifansky, Yan Yang, Yoon Yeo*. Challenges and advances in development of inhalable drug formulations for cystic fibrosis lung disease. Expert Opin. Drug Del. 2011, 8: 451-466.
14. Zhang C, Cui X, Yang Y, Gao F, Sun Y, Gu Jingkai*, Fawcett JP, Yang W, Wang W, Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats. Xenobiotica. 2011, 41: 340-348.
15. Zhang, C., Wang, L., Yang, Y., Sun, Y., Zhang, J., Li, G., and Gu, J*. Validated LC-MS/MS method for the determination of sarpogrelate in human plasma: Application to a pharmacokinetic and bioequivalence study in Chinese volunteers. J Pharm Biomed Anal, 2010, 53(3): 546-551.
16. Liu L, Wu X, Wu D, Wang Y, Li P, Sun Y, Yang Y, Gu Jingkai*, Cui Y, A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin Ib in human plasma: application to a pharmacokinetic study after intravenous administration. Biomed Chromatogr. 2010, 24: 1309-1315.
17. Wantong Song, Mingqiang Li, Zhaohui Tang, Quanshun Li, Yan Yang, Huaiyu Liu, Taicheng Duan, Hua Hong, Xuesi Chen*. Methoxy poly(ethylene glycol)-b-poly (L-glutamic acid) loaded cisplatin and a combination with iRGD for the treatment of non-small cell lung cancers. Macromol. Biosci. 2012-NOV,12(11),1514-1523.
18. Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J. Paul Fawcett, Limei Zhao, Jiangkai Gu*. Determination of landiolol, an ultra-short-acting β1-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2012, 891-892, 7-11.
19. Li, MQ ;Song, WT ;Tang, ZH ; Lv, SX; Lin, L; Sun, H ; Li, QS; Yang, Y; Hong, H; Chen, XS Nanoscaled Poly(L-glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer ACS APPLIED MATERIALS & INTERFACES Volume: 5 Issue: 5 Pages: 1781-1792 Published: MAR 13 2013
20.Lei Yin, Meiyun Shi, Yantong Sun, Xiaocheng Sun, Huan Meng, J. Paul Fawcett,Yan Yang??, Jingkai Gua,? A liquid chromatography–tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study;Journal of Chromatography B, 931 (2013) 12–16
21. 杨艳,李冰,孙英华,方金玲,何仲贵*. 注射用兰索拉唑与常用输液的配伍稳定性. 中国新药杂志,2007, 16(10): 794-796.
22. 杨艳,谢俊霞,李冰,孙英华,方金玲,刘艳,何仲贵*. HPLC测定注射用兰索拉唑中兰索拉唑的含量和有关物质. 中国药学杂志,2006, 41(7): 538-540.
23. 李全顺, 杨艳, 高贵, 于洋, 施维*. 脂肪酶催化选择性开环聚合反应研究进展. 生物加工过程 2011, 9: 71-78.
24. 刘明远,杨艳,高瞰,孙严彤,杜晓琳,闫婷婷,顾静凯*. O-去甲基文拉法辛对大鼠肝微粒体细胞色素P450酶含量及CYP2D6、CYP3A4活性的影响. 中国老年学杂志,2007, 27(7): 632-633.
25. 方金玲, 孙国祥, 李冰, 杨艳, 何仲贵*. HPLC测定马来酸法舒地尔注射液中马来酸法舒地尔含量和有关物质. 中国药学杂志,2006, 41(18): 1417-1419.
会议论文:
1. Yeo, Y., Yang, Y., Bajaj, N., Xu, P.: Development of Highly Porous PLGA Microparticles for Sustained Local Drug Delivery to the Lung. Proceedings of the 35th Annual Meeting of the Controlled Release Society, 35: #933, 2008.
2. Yang, Y., Tsifansky, M.D., and Yeo, Y.: Inhalable Microparticles for Co-Delivery of rhDNase and Ciprofloxacin to Cystic Fibrosis Airway. An abstract and poster presented at the 2009 AAPS National Biotechnology Conference, Seattle, WA, AAPS Journal. 2009; Vol. 11. No. S1
着作教材: 1. 《Biomedical Nanosensors》, Publication date: 15 Jun 2011, Publisher: Pan Stanford Publishing 编写其中一章
2. 参与编译《药物生物利用度》(化学工业出版社, 2007)

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