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蔡勇
基本情况
姓名: 蔡勇
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
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详细情况
所在学科专业: 生物化学
所研究方向: 1.人Ino80染色质重塑酶复合物的结构及其生物学功能。2.染色质修饰酶之间的相互作用及其协同关系。3.癌症发生发展的表观遗传学调控机制及其诊断的生物标记物和靶向治疗药物的筛选和研发。4.胚胎干细胞的自我更新和分化,以及体细胞重编程(iPS)时表观遗传学调控机制。
讲授课程: 1.本科唐敖庆班生化学酶学部分
2.研究生课程:表观遗传学
教育经历: 1985年毕业于原白求恩医科大学医疗系(学士);
1988-1991年在中国医科大学第一临床医院血液内科获得医学硕士学位(导师:单书春教授);
1998年获日本九州大学医学部生化学医学博士学位(导师:滨崎直孝教授);
工作经历: 1998-2000年日本东京医科齿科大学难治疾病研究所遗传生化学研究室,研究员(教授:北岛繁孝);
2001-2009年美国Stowers医学研究所,博士后到研究员,从事表观遗传学方面的研究;
2009年8月应聘为吉林大学生命科学学院教授和博士生导师,吉林大学唐敖庆特聘教授。
科研项目: 1.吉林大学唐敖庆特聘教授启动资金(2009年)。
2.中国科学学院北京生物物理所生物大分子研究室开放课题(2010年)。
3.国家自然科学基金,面上项目(2011-2014年),项目号(31071131)。
4.吉林省人才开发资金资助项目(2011年)。
5.国家自然科学基金,面上项目(2012-2016年),项目号(31171245)。
学术论文: 1. Ning Liu, Rui Zhang, Xiaoming Zhao, Jiaming Su, Xiaolei Bian, Jinsong Ni, Ying Yue, Yong Cai and Jingji Jin. A potential diagnostic marker for ovarian cancer:Involvement of the histone
acetyltransferase,human males absent on the first. Oncology Letters, 2013
2. Wu D, Zhang R, Zhao R, Chen G, Yong Cai, Jin J. A Novel Function of Novobiocin: Disrupting the Interaction of HIF 1α and p300/CBP through Direct Binding to the HIF1α C-Terminal Activation Domain. PLoS One. 2013, 6;8(5):e62014.
3. Yong Wang, Rui Zhang, Donglu Wu, Zhihua Lu, Wentao Sun, Yong Cai, Chunxi Wang, and Jingji Jin .Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma. J Exp Clin Cancer Res. 2013, 32(1): 8.
4. Chen L, Yong Cai, Jin, J.,Florens L, Swanson SK, Washburn MP, Conaway JW, and Conaway RC. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Journal of Biological Chemistry, 2011, 1;286(13):11283-9.
5. Capotosti F, Guernier S, Lammers F, Waridel P, Yong Cai, Jin, J.,Conaway JW, Conaway RC, and Herr W. O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1. Cell, 2011, 144: 376-88.
6. Yong Cai, Jin, J., Swanson SK, Cole MD, Choi SH, Florens LF, Warshburn MP, Conaway JW, and Conaway RC. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Journal of Biological Chemistry, 2010, 285: 4268-72.
7. Gottschalk AJ, Timinszky G, Kong SE, Jin J, Yong Cai, Swanson SK, Washburn MP, Ladurner AG, Conaway JW, Conaway RC. Poly (ADP-ribosyl) ation directs recruitment and activation of an ATP_dependent chromatin remodeler. Proc Natl Acad Sci., 2009, 106, 13770-4.
8. Yao, T., Song, L., Jin, J., Yong Cai, Takahashi, H., Swanson, S.K., Washburn, M.P., Florens, L., Conaway, R.C., Cohen, R.E., and Conaway, J.W. (2008) Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin remodeling complex. Molecular Cell, 31, 909-17.
9. Sardiu, M.E., Yong Cai, Jin, J., Swanson, S.K., Conaway, R.C., Conaway J.W., Florens, L., and Washburn, M.P.. (2008) Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Proceedings of the National Academy of Sciences, 105, 1454–59.
10. Yong Cai, Jin, J., Yao, T., Gottschalk, A.J., Swanson, S.K., Wu, S., Shi, Y., Washburn, M.P., Florens, L., Conaway, R.C., and Conaway, J.W. (2007) YY1 functions with INO80 to activate transcription. Nature Structural & Molecular Biology, 14, 872 – 74. (co-first author)
11. Donald D. Ruhl, Jingji Jin, Yong Cai, Selene Swanson, Laurence Florens, Michael P. Washburn, Ronald C. Conaway, Joan W. Conaway and John C. Chrivia (2006) Purification of human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Biochemistry, 45, 5671-77.
12. Yong Cai, Jingji Jin, Aaron J. Gottschalk, Tingting Yao, Joan W. Conaway and Ronald C. Conaway (2006) Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes. Methods, 40, 312-17.
13. Jin, J., Yong Cai, Li, B., Conaway, RC., Conaway, JW., Workman, JL. and Kusch, T (2005) In and out: Histone variant exchange in chromatin. Trends in Biochemical Sciences, 30, 680-87.
14. Jin, J., Yong Cai, Yao, T., Gottschalk, A., Florence, F., Swanson, SK., Gutierrez, J., Coleman, MK., Workman, JL., Mushegian, A., Washburn, MP., Conaway, RC and Conaway, JW (2005) A mammalian chromatin remodeling complex with similarities to the yeast Ino80 complex. Journal of Biological Chemistry, 280, 41207-12. (co-first author)
15. Yong Cai, Jin, J., Florens, L., Swanson, SK., Kusch, T., Li, B., Workman, JL., Washburn, MP., Conaway, RC., and Conaway, JW (2005) The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. Journal of Biological Chemistry, 280, 13665-70. (co-first author)
16. Yan, Q., Kamura, T., Yong Cai, Jin, J., Ivan, M., Mushegian, A., Conaway, R.C. and Conaway, J.W. (2004) Identification of elongin C and Skp1 sequences that determine cullin selection. Journal of Biological Chemistry, 279, 43019-26.
17. Sato, S., Tomomori-Sato, C., Parmely, T.J., Florens, L., Zybailov, B., Swanson, S.K., Banks, C.A., Jin, J., Yong Cai, Washburn, M.P., Conaway, J.W. and Conaway, R.C. (2004) A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Molecular Cell, 14, 685-91.
18. Yong Cai, Jin, J., Tomomori-Sato, C., Sato, S., Sorokin, I., Parmely, TJ., Conaway, RC. and Conaway, JW (2003) Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. Journal of Biological Chemistry, 278, 42733-6. (co-first author)
19. Zhang, C., Yong Cai, Adachi, MT., Oshiro, S., Aso, T., Kaufman, RJ., Kitajima, S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. Journal of Biological Chemistry, 276, 35867-74.
20. Yong Cai, Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., Kitajima, S (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element. Blood, 96, 2140-8.
社会兼职: 2011年,吉林省生化学会理事;
2011年,浙江省自然科学基金评审委员;
2013年,中国细胞生物学会细胞结构与功能分会委员;
治学格言: 培养兴趣,主观能动;严谨计划,提高效率;基础研究,转化应用。

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