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张海红
基本情况
姓名: 张海红
性别:
职称: 副教授
最高学历: 研究生
最高学位: 博士
Email:
详细情况
所在学科专业: 生物化学与分子生物学
所研究方向: 肿瘤免疫治疗:主要包括对肿瘤抗原的筛选和设计、肿瘤疫苗的不同载体形式、不同免疫佐剂、不同免疫策略等方面的研究。
讲授课程: 本科生的分子生物学及免疫学
教育经历: 1999.9-2003.7 吉林师范大学生命科学学院 本科
2003.9-2006.7 吉林大学生命科学学院 硕士
2006.9-2009.7 吉林大学生命科学学院 博士
工作经历: 2009.7-2012.09 吉林大学生命科学学院艾滋病疫苗国家工程实验室 讲师
2012.10-现在 吉林大学生命科学学院艾滋病疫苗国家工程实验室 副教授
科研项目: 1.肿瘤治疗性疫苗的研究 长春百克生物科技股份公司 2012-2019 负责人
2.多肽-重组流感疫苗临床前安全性评价(2012ZX10001-009-12)十二五国家科技重大专项子课题 2013.6 -2015.5 负责人
3.HIV-1 Vpu 与宿主细胞限制因子Tetherin 的拮抗作用(812111027)国家自然基金(NIH-NSFC合作项目)2013.01-2.13.12 主要参加人
4.钙离子介导的HIV-1 Vpu拮抗Tetherin作用机制的研究(31270807)国家自然基金 2013.01-2016.12 主要参加人
5.提高艾滋病疫苗体液、细胞和粘膜免疫的新型佐剂的设计与评价
(2008ZX10001-012-07)十一五国家科技重大专项子课题 2009.01-2010.12 负责人
6.以Survivin和MUC1 VNTRs 为靶点的肿瘤基因疫苗异源prime-boost 免疫策略的研究(200903255) 2009.12-2011.12负责人
7.以Survivin和MUC1 VNTRs 为靶点的肿瘤基因疫苗免疫佐剂的效果研究 (450060323260 ) 吉林大学 2011.01-2012.12 负责人
8.六邻体嵌合型rAd5载体逃避机体预存免疫的机制(30872396)国家自然基金 2009-2011 第一参加人
学术论文: 近5年发表的论文:
1. Haihong Zhang, Yuqian Wang, Chenlu Liu, Lixing Zhang, Qiu Xia, Yong Zhang, Jiaxin Wu, Chunlai Jiang, Yan Chen, Yongge Wu, Xiao Zha, Xianghui Yu and Wei Kong. DNA and Adenovirus Tumor Vaccine Expressing Truncated Survivin Generates Specific Immune Responses and Antitumor Effects in a Murine Melanoma Model. Cancer Immunology Immunotherapy. 2012, 61:1857–1867.
2. Yu-Qian Wang1, Hai-Hong Zhang1, Chen-Lu Liu, Hui Wu, Peng Wang, Qiu Xia, Li-Xing Zhang, Bo Li, Jia-Xin Wu, Bin Yu, Tie-Jun Gu, Xiang-Hui Yu*, Wei Kong*. Enhancement of survivin-specific anti-tumor immunity by adenovirus prime protein-boost immunity strategy with DDA/MPL adjuvant in a murine melanoma model. International Immunopharmacology. (Accepted)
3. Hui Wu,† Haihong Zhang,† Peng Wang, Zhuo Mao, Li Feng, Yuqian Wang, Chenlu Liu, Qiu Xia, Bo Li, Heya Zhao, Yan Chen, Jiaxin Wu, Wei Kong,* Xianghui Yu*,Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas. Genes Chromosomes Cancer. 2013 Jul; 52(7):644-55.
4.Yu-Qian Wang&, Hai-Hong Zhang&, Chen-Lu Liu, Qiu Xia, Hui Wu, Xiang-Hui Yu*, Wei Kong*. Correlation between auto-antibodies to survivin and MUC1 VNTR in colorectal cancer. Asian Pacific Journal of Cancer Prevention. 2012, 13: 5557-62.
5. Bo Sun, XiangHui Yu, Wei Kong, Shiyang Sun, Ping Yang, Changlin Zhu, Haihong Zhang, Yongge Wu, Yan Chen, Yuhua Shi, Xizhen Zhang, Chunlai Jiang. Production of influenza H1N1 vaccine from MDCK cells using a novel disposable packed-bed bioreactor. Appl Microbiol Biotechnol. 2012 Sep 4. [Epub ahead of print]
6. Wei Wei, Zheng Hu, Hanjing Fu, Yi Tie, Haihong Zhang, Yongge Wu, Xiaofei Zheng, MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. Oncol Rep. 2012, 28(2):701-6.
7. Bin Yu, Chu Wang, Jianing Dong, Min Zhang, Haihong Zhang, Jiaxin Wua, Yuqing Wu, Wei Kong, Xianghui Yu, Chimeric hexon HVRs protein reflects partial function of adenovirus. Biochemical and Biophysical Research Communications. 2012, 421:170–176.
8. Tao Zuo, Donglai Liu, Wei Lv, Xiaodan Wang, Jiawen Wang, Mingyu Lv, Wenlin Huang, Jiaxin Wu, Haihong Zhang, Hongwei Jin, Liangren Zhang, Wei Kong, and Xianghui Yu. Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC. J Virol. 2012, 86(10):5497-507.
9. Mengshu Wang, Bingxue Sun, Jiao Feng, Haihong Zhang, Bin Liu, Chun Li, Yan Chen, Yong Zhang and Wei Kong. Investigation of Transport Mechanism of Exendin-4 across Madin Darby Canine Kidney Cell Monolayers. Biol. Pharm. Bull. 2012, 35(5) 745–752.
10. ZHANG Li-xing, DU Jian-shi, WANG Yu-qian, LIU Chen-lu, XIA Qiu, ZHANG Xi-zhen, Yu Xiang-hui, Kong Wei, CONG Xian-ling, ZHANG Hai-hong. Establishment of a Tumor-bearing Mouse Model Stably Expressing Human Tumor Antigens Survivin and MUC1 VNTR. Chemical Research In Chinese Universities, 2012, 28(2), 259-263.
11. Yang Gao, Huafei Zhang, Min Zhang, Haihong Zhang, Xianghui Yu, Wei Kong, Xiao Zha, and Yuqing Wu. N-Terminal Deletion Effects of Human Survivin on Dimerization and Binding to Smac/DIABLO in Vitro. J. Phys. Chem. B. 2010, 114, 15656–15662.
12. ZHANG Haihong, ZHANG Shuzi, YU Xianghui, KONG Wei. Construction and Expression of Human Survivin and Preparation of Its Polyclonal Antibody. Chemical Research In Chinese Universities. 2008, 24(6), 767-770.
13. ZHANG Shu-zi,ZHANG Hai-hong,ZHANG Wa,SHI He-liang,YU Xiang-hui,KONG Wei, LI Wei. Establishment of a Tumor-bearing Mouse model Stably Expressing EGFP labeled Human Muc1 VNTR. Chemical Research In Chinese Universities. 2008, 24(4), 505-510.
14. Zhang Shuzi,Zhang Haihong,Shi Heliang,Yu Xianghui,Kong Wei, Li Wei. Induction of anti-tumor immune response in mice with a DNA vaccine encoding Human Muc1 VNTR. Human Immunolog. 2008, 69, 250-258.
15. 张丽星, 张喜珍, 王玉倩, 刘晨露, 夏秋, 孔维, 于湘晖, 张海红,双顺反子表达载体DV的构建及其表达效率, 中国生物制品学杂志, 2011, 24(9): 1016-1021.
16. 张淑子,张海红,于湘晖,孔维,李惟. 人粘蛋白1串联重复区DNA疫苗诱导小鼠的免疫应答。中国生物制品学杂志,2007, 20 (10)∶ 729-732.
17. 张淑子,张娲,张海红,吴永革,于湘晖,孔维. 人粘蛋白1串联重复区基因真核表达载体的构建及其在动物细胞中的表达. 中国生物制品学杂志. 2007, 20(9):642-645.
18. 张文彬,张海红,孔维,查晓,陈廷清,邓碧芳,任原,黄建鸣. 转染融合基因的DC抗肿瘤免疫效应. 肿瘤防治研究. 2007, 34 (9): 647-50,736.

专利:
1. 以粘蛋白1和生存素为靶点的肿瘤DNA疫苗和病毒载体疫苗(公开号:CN 102086453 A),发明人:孔维 张海红 于湘晖 于永慧
2. 以粘蛋白1和生存素为靶点的肿瘤基因工程疫苗(申请号: 201110086366.1),发明人:孔维 张海红 于湘晖 于永慧 王玉倩 张丽星
治学格言: 兴趣是最好的老师

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