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李又欣
基本情况
姓名: 李又欣
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
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详细情况
所在学科专业: 药学
所研究方向: 创新药物与新制剂的研究
讲授课程: 本科生:药用高分子材料
教育经历: 1978.9-1982.7 北京大学化学系攻读学士学位
1982.9-1985.7 北京大学化学系攻读硕士学位
1985.9-1988.7 北京大学化学系攻读博士学位
工作经历: 1988.7-1991.4 中国科学院化学所,助理研究员
1991.4-1994.1 德国PHILIPPS大学高分子研究所及药学技术与生物药学研究所, 研究员
1994.1-1998.3 德国Aventis/Hoechst公司任科研中心研究员
1998.3-2007.4 德国SCHWARZ PHARMA制药公司任高分子化学部主任及项目经理
2006.4-至今 吉林大学生命科学学院教授,博士生导师
学术论文: 主持开发的治疗帕金森氏症的新药Rotigotine贴剂已成功在欧美上市,作为技术骨干参与研发的治疗尿失禁的新药Fesoterodine以及治疗癫痫的新药Harcoseride都已在欧美上市,主持的“治疗糖尿病晚期并发症C-peptide注射用长效缓释微球制剂”已进入I期临床实验,在新药研发尤其是长效缓释微球制剂的开发方面积累了丰富的经验,发明多种用于长效缓释微球制剂的生物可降解材料,其中3种已成功进行工业化开发。获美国专利2项,德国专利1项,欧洲专利1项,在审专利8项。于国际权威刊物发表论文50余篇,被引800余次,其中160次以上为2篇,80次以上为4篇。参加大型国际学术会议并发表论文20余次。
主要论著:
(1)Lexi Wang, Aiping Wang, Xiaolei Zhao, Ximing Liu, Dan Wang, Fengying Sun*, Youxin Li*. Design of a long-term anti-psychotic in situ forming implant and its release control method and mechanism. International Journal of Pharmaceutics.
(2)Zhengxing Su, Yanan Shi, Lesheng Teng, Lexi Wang, Qingfan Meng, Lirong Teng, Youxin Li*. Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres for sustained release of risperidone: Zero-order release formulation. Pharmaceutical Development and Technology. Posted online on 7 Apr 2010.
(3)Fengying Sun, Zhengxing Su, Cheng Sui, Chao Zhang, Lijia Yuan, Qingfan Meng, Lirong Teng, Youxin Li*. Studies on the acute toxicity, pharmacokinetics and pharmacodynamics of paliperidone derivatives - comparison to paliperidone and risperidone in mice and rats. Basic & Clinical Pharmacology & Toxicology. 2010, 107(2): 656-662.
(4)Fengying Sun, Cheng Sui, Lesheng Teng, Ximing Liu, Lirong Teng, Qingfan Meng, Youxin Li*. Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres. International Journal of Pharmaceutics. 2010, 397(1-2): 44-49.
(5)Lesheng Teng, Chaojun Jiang, Xiangyou Lin, Yuanchen Dong, Chunmei Li, Qingfan Meng, Youxin Li*. Preparation of Tolterodine Metabolite Loaded Biodegradable PLGA Microspheres. Chemical Research in Chinese Universities. 2010, 26(1): 75-80.
(6)Fanxin Meng, Youxin Li, Weiliang Guo, Jiahui Lu, Linna Du, Lirong Teng*. Optimization of Fermentation Medium for Epothilones Production with Sequential Statistical Approach. Chemical Research in Chinese Universities. 2010, 26(1): 86-91.
(7)Zhengxing Su, Fengying Sun, Yanan Shi, Chaojun Jiang, Qingfan Meng, Lirong Teng, Youxin Li*. Effects of formulation parameters on encapsulation efficiency and release behavior of risperidone poly(D, L-lactide-co-glycolide) microsphere. Chemical & Pharmaceutical Bulletin. 2009, 57(11): 1251-1256.
(8)Chaojun Jiang, Lesheng Teng, Lirong Teng, Chunmei Li, Youxin Li*. Biodegradable PLGA microsphere for the controlled release of tolterodine derivative. Journal of Biotechnology. 2008, 136(1): S416-S417.
(9)Dafeng Chu, Jingwei Tian, Wanhui Liu, Zi Li, Youxin Li*. Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: in vitro and in vivo studies and the application in the treatment of the impaired memory of mice. Chemical & Pharmaceutical Bulletin. 2007, 55(4): 625-628.
(10)Dafeng Chu, Xueqi Fu, Wanhui Liu, Ke Liu, Youxin Li*. Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs. International Journal of Pharmaceutics. 2006, 325(1-2): 116-123.
社会兼职: 国际纯化学与应用化学联合会(IUPAC)会员、国际控制释放学会会员、美国化学学会会员兼任亚洲药业集团研发副总裁。

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