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赵志壮
基本情况
姓名: 赵志壮
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
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详细情况
所在学科专业: 生物化学与分子生物学
所研究方向: Tyrosine Kinases and Phosphatases in Cell Signaling and in Diseases
教育经历: 1979-1984 吉林大学生命科学学院 本科
1985-1990 俄勒冈州立大学 博士
学术论文: 部分论文
1、Runxiang Zhao, Shu Xing, Zhe Li, Xueqi Fu, Qingshan Li, Sanford B. Krantz, Z. Joe Zhao. Identification of an Acquired JAK2 Mutation in Polycythemia Vera. J. Biol. Chem. 280, 22788-22792 (2005).

2、Xuesong Xu, Qi Zhang, Jian Luo, Shu Xing, Qingshan Li, Sanford B. Krantz, Xueqi Fu, Zhizhuang Joe Zhao. JAK2V617F: Prevalence in a Large Chinese Hospital Population. Blood. 109, 339-342. (2007)

3、Zhe Li, Mingjiang Xu, Shu Xing, Wanting Tina Ho, Takefumi Ishii, Qingshan Li, Xueqi Fu, Zhizhuang Joe Zhao. Erlotinib Effectively Inhibits JAK2V617F Activity and Polycythemia Vera Cell Growth. J Biol Chem. 282(6):3428-32. (2007).

4、Junfeng Ma, Fenghua Zeng, Wanting Ho, Lirong Teng, Qingshan Li, Xueqi Fu, Zhizhuang Joe Zhao. Characterization and Functional Studies of a FYVE Domain-Containing Phosphatase in C. elegans. J. Cellular. Biochem. 2008;104:1843-52. PMID: 18393358.

5、Shu Xing, Wanting Tina Ho, Wanming Zhao, Junfeng Ma, Shaofeng Wang, Xuesong Xu, Qingshan Li, Xueqi Fu, Mingjiang Xu, Zhizhuang Joe Zhao. Transgenic Expression of JAK2V617F Causes Myeloproliferative Disorders in Mice. Blood. 2008;111 5109-5117. PMID: 18334677.

6、Wanming Zhao, Rufei Gao, Jiyun Lee, Shu Xing, Wanting T Ho, Xueqi Fu, Shibo L, Zhizhuang Joe Zhao. Relevance of JAK2V617F positivity to hematological diseases - survey of samples from a clinical genetics laboratory. J. Hematol. Oncol. 2011 Jan 14;4(1):4. PMCID: PMC3032761

7、Junfeng Ma, Zhe Li, Shu Xing, Wanting T Ho, Xueqi Fu, Zhizhuang Joe Zhao. Tea contains potent inhibitors of tyrosine phosphatase PTP1B. Biochem. Biophys. Res. Commun. 2011 Apr 1;407(1):98-102. Epub 2011 Feb 28.

8、Xiaokun Yu; Wanming Zhao; Junfeng Ma; Xueqi Fu; Zhizhuang Joe Zhao. Beneficial and Harmful Effects of Alcohol Exposure on Caenorhabditis elegans Worms. Biochem. Biophys. Res. Commun. 2011 Sep 9;412(4):757-62. Epub 2011 Aug 17. PMID: 21871869

9、Anna H. Zhao, Rufei Gao, and Zhizhuang Joe Zhao. Development of a highly sensitive method for detection of JAK2V617F. J Hematol Oncol. 2011 Oct 10;4:40. PMID: 21985400

10、Gao R, Zhao AH, Du Y, Ho WT, Fu X, Zhao ZJ. PCR artifacts can explain the reported biallelic JAK2 mutations. Blood Cancer J. 2012 Feb;2(2):e56. PMID:22829246.

11、Zhao W, Du Y, Ho WT, Fu X, Zhao ZJ. JAK2V617F and p53 mutations coexist in erythroleukemia and megakaryoblastic leukemic cell lines. Exp Hematol Oncol. 2012 Jun 21;1(1):15. PMID:23210734. PMCID:PMC3514099

12、Yu X, Ma J, Lin F, Zhao W, Fu X, Zhao ZJ. Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans. BMC Cell Biol. 2012 Oct 31;13:28. PMID:23114011.

13、Guo Y, Chen Y, Xu X, Fu X, Zhao ZJ. SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. J Hematol Oncol. 2012 Dec 6;5(1):72. PMID:23216927

14、Hassed SJ, Wiley GB, Wang S, Lee JY, Li S, Xu W, Zhao ZJ, Mulvihill JJ, Robertson J, Warner J, Gaffney PM. RBPJ mutations identified in two families affected by Adams-Oliver syndrome. Am J Hum Genet. 2012 Aug 10;91(2):391-5. PMID:22883147

15、Andrew Chow, Matthew Huggins, Jalal Ahmed, Daigo Hashimoto, Daniel Lucas, Yuya Kunisaki, Sandra Pinho, Marylene Leboeuf, Clara Noizat, Nico van Rooijen, Masato Tanaka, Zhizhuang Joe Zhao, Aviv Bergman, Miriam Merad & Paul S Frenette. CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nature Medicine. 2013 Apr;19(4):429-36. PMID:23502962

16、Jian Zhong Tang, Catherine Carmichael, Wei Shi, Donald Metcalf, Ashley P. Ng, Craig D. Hyland, Nancy A. Jenkins, Neal G. Copeland, Viive M. Howell, Zhizhuang Joe Zhao, Gordon K. Smyth, Benjamin T. Kile, Warren S. Alexander. Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6091-6. PMCID:PMC3625293
获奖情况: 2004年被评为“长江学者特聘教授”。2010年获年吉林省科技进步一等奖。

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