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师资队伍
单亚明
基本情况
姓名: 单亚明
性别:
职称: 教授
最高学历: 研究生
最高学位: 博士
电话:
Email:
详细情况
所在学科专业: 微生物学
所研究方向: 多肽疫苗设计及免疫学研究;多肽靶向药物筛选研究。
讲授课程: 生物化学(I)
微生物学实验
教育经历: 1995年-1999年 吉林大学生命科学学院 学士学位
1999年-2005年 吉林大学生命科学学院 博士学位
工作经历: 2003年-现在 吉林大学生命科学学院
2010年-2011年 University of Missouri-St. Louis
2011年-2012年 Washington University in St. Louis
科研项目: 1.国家自然科学基金,项目编号:30700998,负责人。
2.吉林省科技厅,项目编号:20130204016YY,负责人。
3.“十一五”重大专项,项目编号:2008ZX10001-012,子课题负责。
2.“十二五”重大专项,项目编号:2012ZX10001-009,子课题负责。
学术论文: 1. Zhang L, Jiang C, Zhang H, Gong X, Yang L, Miao L, Shi Y, Zhang Y, Kong W, Zhang C, Shan Y*. A novel modified peptide derived from membrane-proximal external region of human immunodeficiency virus type 1 envelope significantly enhances retrovirus infection. J Pept Sci. 2014; 20:46-54.
2. Zhang L, Miao L, Gong X, Zhang H, Yang L, Shi Y, Kong W, Jiang C, Shan Y*. Multiple antigen peptide mimetics containing gp41 membrane-proximal external region elicit broad neutralizing antibodies against human immunodeficiency virus type 1 in guinea pigs. J Pept Sci. 2013; 19:491-8.
3. Wang X, Zhang B, Xu D, Gao J, Wang L, Wang Z, Shan Y*, Yu X. Purification, crystallization and preliminary X-ray crystallographic analysis of the CIDE-N domain of Fsp27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012; 68:1529-33.
4. Shan Y, Liu J, Rath NP, Gokel GW. Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates. Nat Prod Commun. 2012; 7:333-6.
5. Liu B, Dong Q, Wang M, Shi L, Wu Y, Yu X, Shi Y, Shan Y, Jiang C, Zhang X, Gu T, Chen Y, Kong W. Preparation, characterization, and pharmacodynamics of exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres. Chem Pharm Bull (Tokyo). 2010; 58:1474-9.
6. Sun L, Zang Y, Sun M, Wang H, Zhu X, Xu S, Yang Q, Li Y, Shan Y*. Synthesis of magnetic and fluorescent multifunctional hollow silica nanocomposites for live cell imaging. J Colloid Interface Sci. 2010; 350:90-8.
7. Shan Y, Wang L, Shi Y, Zhang H, Li H, Liu H, Yang B, Li T, Fang X, Li W. NHS-mediated QDs-peptide/protein conjugation and its application for cell labeling. Talanta. 2008; 75:1008-14.
8. Zhou X, Liu B, Yu X, Zha X, Zhang X, Wang X, Jin Y, Wu Y, Chen Y, Shan Y, Chen Y, Liu J, Kong W, Shen J. Controlled release of PEI/DNA complexes from PLGA microspheres as a potent delivery system to enhance immune response to HIV vaccine DNA prime/MVA boost regime. Eur J Pharm Biopharm. 2008; 68:589-95.
9. Zhou X, Zhang X, Yu X, Zha X, Fu Q, Liu B, Wang X, Chen Y, Chen Y, Shan Y, Jin Y, Wu Y, Liu J, Kong W, Shen J. The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine. Biomaterials. 2008; 29(1):111-7.
10. Zhou X, Liu B, Yu X, Zha X, Zhang X, Wang X, Chen Y, Chen Y, Chen Y, Shan Y, Jin Y, Wu Y, Liu J, Kong W, Shen J. Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly. Biomaterials. 2007; 28(31):4684-92.
11. Zhou X, Liu B, Yu X, Zha X, Zhang X, Chen Y, Wang X, Jin Y, Wu Y, Chen Y, Shan Y, Chen Y, Liu J, Kong W, Shen J. Controlled release of PEI/DNA complexes from mannose-bearing chitosan microspheres as a potent delivery system to enhance immune response to HBV DNA vaccine. J Control Release. 2007; 121:200-7.
12. Zhou XF, Liu B, Yu XH, Zha X, Zhang XZ, Wang XY, Jin YH, Wu YG, Jiang CL, Chen Y, Chen Y, Shan YM, Liu JQ, Kong W, Shen JC. Using magnetic force to enhance immune response to DNA vaccine. Small. 2007; 3:1707-13.
13. Qiu AD, Wu EQ, Yu XH, Jiang CL, Jin YH, Wu YG, Chen Y, Chen Y, Shan YM, Zhang GN, Fan Y, Zha X, Kong W. HPV prevalence, E6 sequence variation and physical state of HPV16 isolates from patients with cervical cancer in Sichuan, China. Gynecol Oncol. 2007; 104:77-85.
着作教材: 生物化学(第三版)导读版,科学出版社,主编,2009.08

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