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姜春来
基本情况
姓名: 姜春来
性别:
职务: 副院长
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
电话:
Email:
详细情况
所在学科专业: 生物学
所研究方向: 1.传染性疾病的预防(HIV疫苗;手足口病疫苗的研究;重组结核病疫苗的研究);2. HIV分子病毒学;
讲授课程: 医学免疫学,分子病毒学
教育经历: 1991~1995,四川大学,理学学士
1997~2000,长春生物制品所,医学免疫学硕士
2001~2005,吉林大学,生物化学和分子生物学博士

工作经历: 2006~2009,Duke University Human Vaccine Institute, Research Associate
学术论文: 1: Qi Y, Zhang F, Zhang L, Harrison TJ, Huang W, Zhao C, Kong W, Jiang C, Wang Y.
Hepatitis E Virus Produced from Cell Culture Has a Lipid Envelope. PLoS One. 2015
Jul 10;10(7):e0132503. doi: 10.1371/journal.pone.0132503. eCollection 2015.
PubMed PMID: 26161670; PubMed Central PMCID: PMC4498737.


2: Zang Y, Du D, Li N, Su W, Liu X, Zhang Y, Nie J, Wang Y, Kong W, Jiang C.
Eliciting neutralizing antibodies against the membrane proximal external region
of HIV-1 Env by chimeric live attenuated influenza A virus vaccines. Vaccine.
2015 Jul 31;33(32):3859-64. doi: 10.1016/j.vaccine.2015.06.072. Epub 2015 Jun 28.
PubMed PMID: 26126669.


3: Lu J, Sun T, Wang D, Dong Y, Xu M, Hou H, Kong FT, Liang C, Gu T, Chen P, Sun
S, Lv X, Jiang C, Kong W, Wu Y. Protective Immune Responses Elicited by Fusion
Protein Containing PsaA and PspA Fragments. Immunol Invest. 2015;44(5):482-96.
doi: 10.3109/08820139.2015.1037956. PubMed PMID: 26107747.


4: Sun S, Gao F, Mao Q, Shao J, Jiang L, Liu D, Wang Y, Yao X, Wu X, Sun B, Zhao
D, Ma Y, Lu J, Kong W, Jiang C, Liang Z. Immunogenicity and protective efficacy
of an EV71 virus-like particle vaccine against lethal challenge in newborn mice.
Hum Vaccin Immunother. 2015 Jun 2:0. [Epub ahead of print] PubMed PMID: 26036916.


5: Fan P, Li X, Su W, Kong W, Kong X, Wang Z, Wang Y, Jiang C, Gao F. Enhanced
Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked
Fluorescence Oligonucleotide Assay. PLoS One. 2015 Apr 27;10(4):e0125701. doi:
10.1371/journal.pone.0125701. eCollection 2015. PubMed PMID: 25915630; PubMed
Central PMCID: PMC4410951.


6: Chen Y, Li N, Zhang T, Huang X, Cai F, Vandergrift N, Xin R, Meng Z, Zhang X,
Jiang C, Xu X, Montefiori DC, Gao F, Wu H. Comprehensive Characterization of the
Transmitted/Founder env Genes From a Single MSM Cohort in China. J Acquir Immune
Defic Syndr. 2015 Aug 1;69(4):403-12. doi: 10.1097/QAI.0000000000000649. PubMed
PMID: 25886933; PubMed Central PMCID: PMC4482776.


7: Fan P, Li X, Sun S, Su W, An D, Gao F, Kong W, Jiang C. Identification of a
common epitope between enterovirus 71 and human MED25 proteins which may explain
virus-associated neurological disease. Viruses. 2015 Mar 27;7(4):1558-77. doi:
10.3390/v7041558. PubMed PMID: 25826188; PubMed Central PMCID: PMC4411665.


8: Qi Y, Fan J, Huang W, Zhao C, Wang Y, Kong FT, Kong W, Jiang C. Expression and
characterization of hepatitis E virus-like particles and non-virus-like particles
from insect cells. Biotechnol Appl Biochem. 2015 Mar 31. doi: 10.1002/bab.1379.
[Epub ahead of print] PubMed PMID: 25824972.


9: Zang Y, Du D, Ge P, Xu Y, Liu X, Zhang Y, Su W, Kiseleva I, Rudenko L, Xu F,
Kong W, Jiang C. Development of one-step real-time PCR assay for titrating
trivalent live attenuated influenza vaccines. Hum Vaccin Immunother.
2014;10(12):3642-8. doi: 10.4161/hv.34453. PubMed PMID: 25483696.


10: Sun S, Jiang L, Liang Z, Mao Q, Su W, Zhang H, Li X, Jin J, Xu L, Zhao D, Fan
P, An D, Yang P, Lu J, Lv X, Sun B, Xu F, Kong W, Jiang C. Evaluation of
monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus
A16 infection in newborn mice. Hum Vaccin Immunother. 2014;10(10):2885-95. doi:
10.4161/hv.29823. PubMed PMID: 25483672.


11: Xu L, Su W, Jin J, Chen J, Li X, Zhang X, Sun M, Sun S, Fan P, An D, Zhang H,
Zhang X, Kong W, Ma T, Jiang C. Identification of luteolin as enterovirus 71 and
coxsackievirus A16 inhibitors through reporter viruses and cell viability-based
screening. Viruses. 2014 Jul 17;6(7):2778-95. doi: 10.3390/v6072778. PubMed PMID:
25036464; PubMed Central PMCID: PMC4113793.


12: Lu J, Sun T, Hou H, Xu M, Gu T, Dong Y, Wang D, Chen P, Wu C, Liang C, Sun S,
Jiang C, Kong W, Wu Y. Detoxified pneumolysin derivative Plym2 directly protects
against pneumococcal infection via induction of inflammatory cytokines. Immunol
Invest. 2014;43(7):717-26. doi: 10.3109/08820139.2014.930478. Epub 2014 Jul 14.
PubMed PMID: 25020076.


13: Zhang H, An D, Liu W, Mao Q, Jin J, Xu L, Sun S, Jiang L, Li X, Shao J, Ma H,
Huang X, Guo S, Chen H, Cheng T, Yang L, Su W, Kong W, Liang Z, Jiang C. Analysis
of cross-reactive neutralizing antibodies in human HFMD serum with an EV71
pseudovirus-based assay. PLoS One. 2014 Jun 25;9(6):e100545. doi:
10.1371/journal.pone.0100545. eCollection 2014. PubMed PMID: 24964084; PubMed
Central PMCID: PMC4070950.


14: Zang Y, Bi J, Du D, Liu X, Zhang Y, Su W, Wu J, Shan Y, Wang S, Kong W, Qiu
A, Jiang C. Development of a Norovirus P particle platform for eliciting
neutralizing antibody responses to the membrane proximal external region of human
immunodeficiency virus type 1 envelope. Protein Pept Lett. 2014;21(12):1230-9.
PubMed PMID: 24939661.


15: Xiang Y, Liu W, Chen Y, Zhang C, Su W, Zhang Y, Sun J, Gao F, Jiang C. The
variable loop 3 in the envelope glycoprotein is critical for the atypical
coreceptor usage of an HIV-1 strain. PLoS One. 2014 Jun 4;9(6):e98058. doi:
10.1371/journal.pone.0098058. eCollection 2014. PubMed PMID: 24897520; PubMed
Central PMCID: PMC4045670.


16: Duan Y, Gu T, Zhang X, Jiang C, Yuan R, Li Z, Wang D, Chen X, Wu C, Chen Y,
Wu Y, Kong W. Negative effects of a disulfide bond mismatch in anti-rabies G
protein single-chain antibody variable fragment FV57. Mol Immunol. 2014
Jun;59(2):136-41. doi: 10.1016/j.molimm.2014.01.006. Epub 2014 Mar 2. PubMed
PMID: 24598312.


17: Zhang L, Jiang C, Zhang H, Gong X, Yang L, Miao L, Shi Y, Zhang Y, Kong W,
Zhang C, Shan Y. A novel modified peptide derived from membrane-proximal external
region of human immunodeficiency virus type 1 envelope significantly enhances
retrovirus infection. J Pept Sci. 2014 Jan;20(1):46-54. doi: 10.1002/psc.2587.
Epub 2013 Nov 19. PubMed PMID: 24254845.


18: Yuan R, Chen X, Chen Y, Gu T, Xi H, Duan Y, Sun B, Yu X, Jiang C, Liu X, Wu
C, Kong W, Wu Y. Preparation and diagnostic use of a novel recombinant
single-chain antibody against rabies virus glycoprotein. Appl Microbiol
Biotechnol. 2014 Feb;98(4):1547-55. doi: 10.1007/s00253-013-5351-6. Epub 2013 Nov
16. PubMed PMID: 24241896.


19: Zheng DD, Pan D, Zha X, Wu Y, Jiang C, Yu X. In vitro monitoring of the
formation of pentamers from the monomer of GST fused HPV 16 L1. Chem Commun
(Camb). 2013 Oct 4;49(76):8546-8. doi: 10.1039/c3cc44986f. PubMed PMID: 23945594.


20: Li X, Fan P, Jin J, Su W, An D, Xu L, Sun S, Zhang Y, Meng X, Gao F, Kong W,
Jiang C. Establishment of cell lines with increased susceptibility to EV71/CA16
by stable overexpression of SCARB2. Virol J. 2013 Aug 6;10:250. doi:
10.1186/1743-422X-10-250. PubMed PMID: 23919614; PubMed Central PMCID:
PMC3765843.

21: Zhang L, Miao L, Gong X, Zhang H, Yang L, Shi Y, Kong W, Jiang C, Shan Y.
Multiple antigen peptide mimetics containing gp41 membrane-proximal external
region elicit broad neutralizing antibodies against human immunodeficiency virus
type 1 in guinea pigs. J Pept Sci. 2013 Aug;19(8):491-8. doi: 10.1002/psc.2526.
Epub 2013 Jun 21. PubMed PMID: 23794478.


22: Sun B, Yu X, Yin Y, Liu X, Wu Y, Chen Y, Zhang X, Jiang C, Kong W.
Large-scale purification of pharmaceutical-grade plasmid DNA using tangential
flow filtration and multi-step chromatography. J Biosci Bioeng. 2013
Sep;116(3):281-6. doi: 10.1016/j.jbiosc.2013.03.015. Epub 2013 May 7. PubMed
PMID: 23660074.


23: Jin J, Ma H, Xu L, An D, Sun S, Huang X, Kong W, Jiang C. Development of a
Coxsackievirus A16 neutralization assay based on pseudoviruses for measurement of
neutralizing antibody titer in human serum. J Virol Methods. 2013
Feb;187(2):362-7. doi: 10.1016/j.jviromet.2012.11.014. Epub 2012 Nov 20. PubMed
PMID: 23178532.


24: Sun B, Yu X, Kong W, Sun S, Yang P, Zhu C, Zhang H, Wu Y, Chen Y, Shi Y,
Zhang X, Jiang C. Production of influenza H1N1 vaccine from MDCK cells using a
novel disposable packed-bed bioreactor. Appl Microbiol Biotechnol. 2013
Feb;97(3):1063-70. doi: 10.1007/s00253-012-4375-7. Epub 2012 Sep 4. PubMed PMID:
22945265.


25: You Q, Wu Y, Wu Y, Wei W, Wang C, Jiang D, Yu X, Zhang X, Wang Y, Tang Z,
Jiang C, Kong W. Immunogenicity and protective efficacy of heterologous
prime-boost regimens with mycobacterial vaccines and recombinant adenovirus- and
poxvirus-vectored vaccines against murine tuberculosis. Int J Infect Dis. 2012
Nov;16(11):e816-25. doi: 10.1016/j.ijid.2012.07.008. Epub 2012 Aug 21. PubMed
PMID: 22921259.


26: Jin J, Han M, Xu L, An D, Kong W, Jiang C. Replication kinetics of
coxsackievirus A16 in human rhabdomyosarcoma cells. Virol Sin. 2012
Aug;27(4):221-7. doi: 10.1007/s12250-012-3245-x. Epub 2012 Jul 28. PubMed PMID:
22899429.


27: Zhang H, Wang Y, Liu C, Zhang L, Xia Q, Zhang Y, Wu J, Jiang C, Chen Y, Wu Y,
Zha X, Yu X, Kong W. DNA and adenovirus tumor vaccine expressing truncated
survivin generates specific immune responses and anti-tumor effects in a murine
melanoma model. Cancer Immunol Immunother. 2012 Oct;61(10):1857-67. Epub 2012 Jun
17. PubMed PMID: 22706381.


28: You Q, Jiang C, Kong W, Wu Y. Attempted immunotherapy for Mycobacterium
tuberculosis with viral and protein vaccines based on Ag85B-ESAT6 in a mouse
model. Acta Microbiol Immunol Hung. 2012 Mar;59(1):63-75. doi:
10.1556/AMicr.59.2012.1.7. PubMed PMID: 22510288.


29: You Q, Wu Y, Jiang D, Wu Y, Wang C, Wei W, Yu X, Zhang X, Kong W, Jiang C.
Immune responses induced by heterologous boosting of recombinant bacillus
Calmette-Guerin with Ag85B-ESAT6 fusion protein in levamisole-based adjuvant.
Immunol Invest. 2012;41(4):412-28. doi: 10.3109/08820139.2012.658940. Epub 2012
Feb 23. PubMed PMID: 22360290.


30: Gnanakaran S, Bhattacharya T, Daniels M, Keele BF, Hraber PT, Lapedes AS,
Shen T, Gaschen B, Krishnamoorthy M, Li H, Decker JM, Salazar-Gonzalez JF, Wang
S, Jiang C, Gao F, Swanstrom R, Anderson JA, Ping LH, Cohen MS, Markowitz M,
Goepfert PA, Saag MS, Eron JJ, Hicks CB, Blattner WA, Tomaras GD, Asmal M, Letvin
NL, Gilbert PB, Decamp AC, Magaret CA, Schief WR, Ban YE, Zhang M, Soderberg KA,
Sodroski JG, Haynes BF, Shaw GM, Hahn BH, Korber B. Recurrent signature patterns
in HIV-1 B clade envelope glycoproteins associated with either early or chronic
infections. PLoS Pathog. 2011 Sep;7(9):e1002209. doi:
10.1371/journal.ppat.1002209. Epub 2011 Sep 29. PubMed PMID: 21980282; PubMed
Central PMCID: PMC3182927.


31: Jiang C, Parrish NF, Wilen CB, Li H, Chen Y, Pavlicek JW, Berg A, Lu X, Song
H, Tilton JC, Pfaff JM, Henning EA, Decker JM, Moody MA, Drinker MS, Schutte R,
Freel S, Tomaras GD, Nedellec R, Mosier DE, Haynes BF, Shaw GM, Hahn BH, Doms RW,
Gao F. Primary infection by a human immunodeficiency virus with atypical
coreceptor tropism. J Virol. 2011 Oct;85(20):10669-81. doi: 10.1128/JVI.05249-11.
Epub 2011 Aug 10. PubMed PMID: 21835785; PubMed Central PMCID: PMC3187499.


32: Liu B, Dong Q, Wang M, Shi L, Wu Y, Yu X, Shi Y, Shan Y, Jiang C, Zhang X, Gu
T, Chen Y, Kong W. Preparation, characterization, and pharmacodynamics of
exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres. Chem Pharm Bull
(Tokyo). 2010 Nov;58(11):1474-9. PubMed PMID: 21048339.


33: Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT, Salazar MG, Sun
C, Grayson T, Wang S, Li H, Wei X, Jiang C, Kirchherr JL, Gao F, Anderson JA,
Ping LH, Swanstrom R, Tomaras GD, Blattner WA, Goepfert PA, Kilby JM, Saag MS,
Delwart EL, Busch MP, Cohen MS, Montefiori DC, Haynes BF, Gaschen B, Athreya GS,
Lee HY, Wood N, Seoighe C, Perelson AS, Bhattacharya T, Korber BT, Hahn BH, Shaw
GM. Identification and characterization of transmitted and early founder virus
envelopes in primary HIV-1 infection. Proc Natl Acad Sci U S A. 2008 May
27;105(21):7552-7. doi: 10.1073/pnas.0802203105. Epub 2008 May 19. PubMed PMID:
18490657; PubMed Central PMCID: PMC2387184.


社会兼职: 中华医学会医学病毒学委员会青年委员会委员
吉林省微生物学会常务理事
吉林省药学会生物制品委员会副主任委员

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