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姜春来
基本情况
姓名: 姜春来
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
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Email:
详细情况
所在学科专业: 生物学
所研究方向: 1.传染性疾病的预防(HIV疫苗;手足口病疫苗的研究;重组结核病疫苗的研究);2. HIV分子病毒学;
讲授课程: 医学免疫学,分子病毒学
教育经历: 1991~1995,四川大学,理学学士
1997~2000,长春生物制品所,医学免疫学硕士
2001~2005,吉林大学,生物化学和分子生物学博士

工作经历: 2006~2009,Duke University Human Vaccine Institute, Research Associate
学术论文: 1: Shi W, Kou Y, Xiao J, Zhang L, Gao F, Kong W, Su W, Jiang C, Zhang Y.
Comparison of immunogenicity, efficacy and transcriptome changes of inactivated
rabies virus vaccine with different adjuvants. Vaccine. 2018 Aug
9;36(33):5020-5029. doi: 10.1016/j.vaccine.2018.07.006. Epub 2018 Jul 7. PubMed
PMID: 30037417.


2: Kou Y, Wan M, Shi W, Liu J, Zhao Z, Xu Y, Wei W, Sun B, Gao F, Cai L, Jiang C.
Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of
Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an
Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. J Microbiol
Biotechnol. 2018 Jun 28;28(6):1022-1029. doi: 10.4014/jmb.1712.12064. PubMed
PMID: 29847865.


3: Song H, Giorgi EE, Ganusov VV, Cai F, Athreya G, Yoon H, Carja O, Hora B,
Hraber P, Romero-Severson E, Jiang C, Li X, Wang S, Li H, Salazar-Gonzalez JF,
Salazar MG, Goonetilleke N, Keele BF, Montefiori DC, Cohen MS, Shaw GM, Hahn BH,
McMichael AJ, Haynes BF, Korber B, Bhattacharya T, Gao F. Tracking HIV-1
recombination to resolve its contribution to HIV-1 evolution in natural
infection. Nat Commun. 2018 May 15;9(1):1928. doi: 10.1038/s41467-018-04217-5.
PubMed PMID: 29765018; PubMed Central PMCID: PMC5954121.


4: Shi W, Kou Y, Jiang H, Gao F, Kong W, Su W, Xu F, Jiang C. Novel intranasal
pertussis vaccine based on bacterium-like particles as a mucosal adjuvant.
Immunol Lett. 2018 Jun;198:26-32. doi: 10.1016/j.imlet.2018.03.012. Epub 2018 Mar
27. PubMed PMID: 29601940.


5: Dai W, Wu Y, Bi J, Wang S, Li F, Kong W, Barbier J, Cintrat JC, Gao F, Gillet
D, Su W, Jiang C. Antiviral Effects of ABMA against Herpes Simplex Virus Type 2
In Vitro and In Vivo. Viruses. 2018 Mar 9;10(3). pii: E119. doi:
10.3390/v10030119. PubMed PMID: 29522484; PubMed Central PMCID: PMC5869512.


6: Wang D, Lu J, Yu J, Hou H, Leenhouts K, Van Roosmalen ML, Gu T, Jiang C, Kong
W, Wu Y. A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like
Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice.
Immunol Invest. 2018 May;47(4):403-415. doi: 10.1080/08820139.2018.1439505. Epub
2018 Mar 2. PubMed PMID: 29498560.


7: Du X, Zhang X, Jiang C, Zhang W, Yang L. The Trace Detection of Nitrite Ions
Using Neutral Red Functionalized SH-β-Cyclodextrin @Au Nanoparticles. Sensors
(Basel). 2018 Feb 25;18(3). pii: E681. doi: 10.3390/s18030681. PubMed PMID:
29495331; PubMed Central PMCID: PMC5877208.


8: Zhao D, Sun B, Sun S, Fu B, Liu C, Liu D, Chu Y, Ma Y, Bai L, Wu Y, Zhou Y, Su
W, Hou A, Cai L, Xu F, Kong W, Jiang C. Characterization of human enterovirus71
virus-like particles used for vaccine antigens. PLoS One. 2017 Jul
21;12(7):e0181182. doi: 10.1371/journal.pone.0181182. eCollection 2017. PubMed
PMID: 28732070; PubMed Central PMCID: PMC5521781.


9: Kou Y, Xu Y, Zhao Z, Liu J, Wu Y, You Q, Wang L, Gao F, Cai L, Jiang C. Tissue
plasminogen activator (tPA) signal sequence enhances immunogenicity of MVA-based
vaccine against tuberculosis. Immunol Lett. 2017 Oct;190:51-57. doi:
10.1016/j.imlet.2017.07.007. Epub 2017 Jul 17. PubMed PMID: 28728855.


10: Dai W, Wu Y, Bi J, Lu X, Hou A, Zhou Y, Sun B, Kong W, Barbier J, Cintrat JC,
Gao F, Gillet D, Su W, Jiang C. Antiviral effects of Retro-2(cycl) and Retro-2.1
against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug;144:311-321.
doi: 10.1016/j.antiviral.2017.07.001. Epub 2017 Jul 5. PubMed PMID: 28688753.


11: Zhou Y, Wang Z, Xu Y, Zhang Z, Hua R, Liu W, Jiang C, Chen Y, Yang W, Kong W.
Optimized DNA Vaccine Enhanced by Adjuvant IL28B Induces Protective Immune
Responses Against Herpes Simplex Virus Type 2 in Mice. Viral Immunol. 2017
Oct;30(8):601-614. doi: 10.1089/vim.2017.0033. Epub 2017 Jun 26. PubMed PMID:
28650722.


12: Su W, Li X, Chen M, Dai W, Sun S, Wang S, Sheng X, Sun S, Gao C, Hou A, Zhou
Y, Sun B, Gao F, Xiao J, Zhang Z, Jiang C. Synonymous codon usage analysis of
hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6,
A10, A16, and enterovirus 71 from 2008 to 2015. Infect Genet Evol. 2017
Sep;53:212-217. doi: 10.1016/j.meegid.2017.06.004. Epub 2017 Jun 15. PubMed PMID:
28602802.


13: Wang C, Jiang C, Gao N, Zhang K, Liu D, Wang W, Cong Z, Qin C, Ganusov VV,
Ferrari G, LaBranche C, Montefiori DC, Kong W, Yu X, Gao F. Immunologic and
Virologic Mechanisms for Partial Protection from Intravenous Challenge by an
Integration-Defective SIV Vaccine. Viruses. 2017 Jun 2;9(6). pii: E135. doi:
10.3390/v9060135. PubMed PMID: 28574482; PubMed Central PMCID: PMC5490812.


14: Lu J, Hou H, Wang D, Leenhouts K, Roosmalen MLV, Sun T, Gu T, Song Y, Jiang
C, Kong W, Wu Y. Systemic and mucosal immune responses elicited by intranasal
immunization with a pneumococcal bacterium-like particle-based vaccine displaying
pneumolysin mutant Plym2. Immunol Lett. 2017 Jul;187:41-46. doi:
10.1016/j.imlet.2017.05.003. Epub 2017 May 6. PubMed PMID: 28487097.


15: Xi H, Zhang K, Yin Y, Gu T, Sun Q, Li Z, Cheng Y, Jiang C, Kong W, Wu Y.
Engineering of a novel zipFv using leucine zipper motif against rabies virus
glycoprotein G with improved protection potency in vivo. Immunol Lett. 2017
Jun;186:9-14. doi: 10.1016/j.imlet.2017.04.001. Epub 2017 Apr 4. PubMed PMID:
28389318.


16: Liu W, Zhou Y, Wang Z, Zhang Z, Wang Q, Su W, Chen Y, Zhang Y, Gao F, Jiang
C, Kong W. Evaluation of recombinant adenovirus vaccines based on glycoprotein D
and truncated UL25 against herpes simplex virus type 2 in mice. Microbiol
Immunol. 2017 May;61(5):176-184. doi: 10.1111/1348-0421.12482. PubMed PMID:
28378925.


17: Jin J, Li R, Jiang C, Zhang R, Ge X, Liang F, Sheng X, Dai W, Chen M, Wu J,
Xiao J, Su W. Transcriptome analysis reveals dynamic changes in coxsackievirus
A16 infected HEK 293T cells. BMC Genomics. 2017 Jan 25;18(Suppl 1):933. doi:
10.1186/s12864-016-3253-6. PubMed PMID: 28198671; PubMed Central PMCID:
PMC5310284.


18: Xi H, Zhang K, Yin Y, Gu T, Sun Q, Shi L, Zhang R, Jiang C, Kong W, Wu Y.
Fusion Peptide Improves Stability and Bioactivity of Single Chain Antibody
against Rabies Virus. J Microbiol Biotechnol. 2017 Apr 28;27(4):718-724. doi:
10.4014/jmb.1611.11062. PubMed PMID: 28068664.


19: Shen Z, Bowen RA, Ge P, Yu J, Shen Y, Kong W, Jiang C, Wu J, Zhu C, Xu Y, Wei
W, Rudenko L, Kiseleva I, Xu F. Evaluation of a candidate live attenuated
influenza vaccine prepared in Changchun BCHT (China) for safety and efficacy in
ferrets. Vaccine. 2016 Nov 21;34(48):5953-5958. doi:
10.1016/j.vaccine.2016.09.059. Epub 2016 Oct 26. PubMed PMID: 27997342.


20: Wang D, Di X, Fu L, Li Y, Han X, Wu H, Cai L, Meng X, Jiang C, Kong W, Su W.
Analysis of serum β-amyloid peptides, α2-macroglobulin, complement factor H, and
clusterin levels in APP/PS1 transgenic mice during progression of Alzheimer's
disease. Neuroreport. 2016 Oct 19;27(15):1114-9. doi:
10.1097/WNR.0000000000000661. PubMed PMID: 27541273.


21: Xi H, Yuan R, Chen X, Gu T, Cheng Y, Li Z, Jiang C, Kong W, Wu Y.
Purification and on-column refolding of a single-chain antibody fragment against
rabies virus glycoprotein expressed in Escherichia coli. Protein Expr Purif. 2016
Oct;126:26-32. doi: 10.1016/j.pep.2016.05.004. Epub 2016 May 5. PubMed PMID:
27157441.


22: Li X, Fan P, Jiang C, Ma T, Yu X, Kong W, Gao F. High-Frequency Illegitimate
Strand Transfers of Nascent DNA Fragments During Reverse Transcription Result in
Defective Retrovirus Genomes. J Acquir Immune Defic Syndr. 2016 Aug
1;72(4):353-62. doi: 10.1097/QAI.0000000000000952. PubMed PMID: 26885810.


23: Gong X, Yin H, Shi Y, Guan S, He X, Yang L, Yu Y, Kuai Z, Jiang C, Kong W,
Wang S, Shan Y. Conserved stem fragment from H3 influenza hemagglutinin elicits
cross-clade neutralizing antibodies through stalk-targeted blocking of
conformational change during membrane fusion. Immunol Lett. 2016 Apr;172:11-20.
doi: 10.1016/j.imlet.2016.02.006. Epub 2016 Feb 10. PubMed PMID: 26875772.


24: Jiang L, Fan R, Sun S, Fan P, Su W, Zhou Y, Gao F, Xu F, Kong W, Jiang C. A
new EV71 VP3 epitope in norovirus P particle vector displays neutralizing
activity and protection in vivo in mice. Vaccine. 2015 Nov 27;33(48):6596-603.
doi: 10.1016/j.vaccine.2015.10.104. Epub 2015 Oct 31. PubMed PMID: 26529072.


25: Cheng Y, Li Z, Xi H, Gu T, Yuan R, Chen X, Jiang C, Kong W, Wu Y. A
VL-linker-VH Orientation Dependent Single Chain Variable Antibody Fragment
Against Rabies Virus G Protein with Enhanced Neutralizing Potency in vivo.
Protein Pept Lett. 2016;23(1):24-32. PubMed PMID: 26497316.


26: Sun B, Zhao D, Zhang X, Gu T, Yu X, Sun S, Zhao X, Wei L, Liu D, Yan H, Meng
X, Kong W, Xu F, Yang P, Jiang C. Development a scalable production process for
truncated human papillomavirus type-6 L1 protein using WAVE Bioreactor and hollow
fiber membrane. Appl Microbiol Biotechnol. 2016 Feb;100(3):1231-40. doi:
10.1007/s00253-015-6974-6. Epub 2015 Oct 8. PubMed PMID: 26446387.


27: Li Z, Cheng Y, Xi H, Gu T, Yuan R, Chen X, Jiang C, Kong W, Wu Y. A novel
variable antibody fragment dimerized by leucine zippers with enhanced
neutralizing potency against rabies virus G protein compared to its corresponding
single-chain variable antibody fragment. Mol Immunol. 2015 Dec;68(2 Pt A):168-75.
doi: 10.1016/j.molimm.2015.06.027. Epub 2015 Aug 29. PubMed PMID: 26325475.


28: Qi Y, Zhang F, Zhang L, Harrison TJ, Huang W, Zhao C, Kong W, Jiang C, Wang
Y. Hepatitis E Virus Produced from Cell Culture Has a Lipid Envelope. PLoS One.
2015 Jul 10;10(7):e0132503. doi: 10.1371/journal.pone.0132503. eCollection 2015.
PubMed PMID: 26161670; PubMed Central PMCID: PMC4498737.


29: Zang Y, Du D, Li N, Su W, Liu X, Zhang Y, Nie J, Wang Y, Kong W, Jiang C.
Eliciting neutralizing antibodies against the membrane proximal external region
of HIV-1 Env by chimeric live attenuated influenza A virus vaccines. Vaccine.
2015 Jul 31;33(32):3859-64. doi: 10.1016/j.vaccine.2015.06.072. Epub 2015 Jun 28.
PubMed PMID: 26126669.


30: Lu J, Sun T, Wang D, Dong Y, Xu M, Hou H, Kong FT, Liang C, Gu T, Chen P, Sun
S, Lv X, Jiang C, Kong W, Wu Y. Protective Immune Responses Elicited by Fusion
Protein Containing PsaA and PspA Fragments. Immunol Invest. 2015;44(5):482-96.
doi: 10.3109/08820139.2015.1037956. PubMed PMID: 26107747.


31: Sun S, Gao F, Mao Q, Shao J, Jiang L, Liu D, Wang Y, Yao X, Wu X, Sun B, Zhao
D, Ma Y, Lu J, Kong W, Jiang C, Liang Z. Immunogenicity and protective efficacy
of an EV71 virus-like particle vaccine against lethal challenge in newborn mice.
Hum Vaccin Immunother. 2015;11(10):2406-13. doi: 10.1080/21645515.2015.1053675.
PubMed PMID: 26036916; PubMed Central PMCID: PMC4635907.


32: Fan P, Li X, Su W, Kong W, Kong X, Wang Z, Wang Y, Jiang C, Gao F. Enhanced
Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked
Fluorescence Oligonucleotide Assay. PLoS One. 2015 Apr 27;10(4):e0125701. doi:
10.1371/journal.pone.0125701. eCollection 2015. PubMed PMID: 25915630; PubMed
Central PMCID: PMC4410951.


33: Chen Y, Li N, Zhang T, Huang X, Cai F, Vandergrift N, Xin R, Meng Z, Zhang X,
Jiang C, Xu X, Montefiori DC, Gao F, Wu H. Comprehensive Characterization of the
Transmitted/Founder env Genes From a Single MSM Cohort in China. J Acquir Immune
Defic Syndr. 2015 Aug 1;69(4):403-12. doi: 10.1097/QAI.0000000000000649. PubMed
PMID: 25886933; PubMed Central PMCID: PMC4482776.


34: Fan P, Li X, Sun S, Su W, An D, Gao F, Kong W, Jiang C. Identification of a
common epitope between enterovirus 71 and human MED25 proteins which may explain
virus-associated neurological disease. Viruses. 2015 Mar 27;7(4):1558-77. doi:
10.3390/v7041558. PubMed PMID: 25826188; PubMed Central PMCID: PMC4411665.


35: Qi Y, Fan J, Huang W, Zhao C, Wang Y, Kong FT, Kong W, Jiang C. Expression
and characterization of hepatitis E virus-like particles and non-virus-like
particles from insect cells. Biotechnol Appl Biochem. 2016 May;63(3):362-70. doi:
10.1002/bab.1379. Epub 2015 Jul 6. Review. PubMed PMID: 25824972.


36: Zang Y, Du D, Ge P, Xu Y, Liu X, Zhang Y, Su W, Kiseleva I, Rudenko L, Xu F,
Kong W, Jiang C. Development of one-step real-time PCR assay for titrating
trivalent live attenuated influenza vaccines. Hum Vaccin Immunother.
2014;10(12):3642-8. doi: 10.4161/hv.34453. PubMed PMID: 25483696; PubMed Central
PMCID: PMC4514063.


37: Sun S, Jiang L, Liang Z, Mao Q, Su W, Zhang H, Li X, Jin J, Xu L, Zhao D, Fan
P, An D, Yang P, Lu J, Lv X, Sun B, Xu F, Kong W, Jiang C. Evaluation of
monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus
A16 infection in newborn mice. Hum Vaccin Immunother. 2014;10(10):2885-95. doi:
10.4161/hv.29823. PubMed PMID: 25483672; PubMed Central PMCID: PMC5443096.


38: Xu L, Su W, Jin J, Chen J, Li X, Zhang X, Sun M, Sun S, Fan P, An D, Zhang H,
Zhang X, Kong W, Ma T, Jiang C. Identification of luteolin as enterovirus 71 and
coxsackievirus A16 inhibitors through reporter viruses and cell viability-based
screening. Viruses. 2014 Jul 17;6(7):2778-95. doi: 10.3390/v6072778. PubMed PMID:
25036464; PubMed Central PMCID: PMC4113793.


39: Lu J, Sun T, Hou H, Xu M, Gu T, Dong Y, Wang D, Chen P, Wu C, Liang C, Sun S,
Jiang C, Kong W, Wu Y. Detoxified pneumolysin derivative Plym2 directly protects
against pneumococcal infection via induction of inflammatory cytokines. Immunol
Invest. 2014;43(7):717-26. doi: 10.3109/08820139.2014.930478. Epub 2014 Jul 14.
PubMed PMID: 25020076.


40: Zhang H, An D, Liu W, Mao Q, Jin J, Xu L, Sun S, Jiang L, Li X, Shao J, Ma H,
Huang X, Guo S, Chen H, Cheng T, Yang L, Su W, Kong W, Liang Z, Jiang C. Analysis
of cross-reactive neutralizing antibodies in human HFMD serum with an EV71
pseudovirus-based assay. PLoS One. 2014 Jun 25;9(6):e100545. doi:
10.1371/journal.pone.0100545. eCollection 2014. PubMed PMID: 24964084; PubMed
Central PMCID: PMC4070950.


41: Zang Y, Bi J, Du D, Liu X, Zhang Y, Su W, Wu J, Shan Y, Wang S, Kong W, Qiu
A, Jiang C. Development of a Norovirus P particle platform for eliciting
neutralizing antibody responses to the membrane proximal external region of human
immunodeficiency virus type 1 envelope. Protein Pept Lett. 2014;21(12):1230-9.
PubMed PMID: 24939661.


42: Xiang Y, Liu W, Chen Y, Zhang C, Su W, Zhang Y, Sun J, Gao F, Jiang C. The
variable loop 3 in the envelope glycoprotein is critical for the atypical
coreceptor usage of an HIV-1 strain. PLoS One. 2014 Jun 4;9(6):e98058. doi:
10.1371/journal.pone.0098058. eCollection 2014. PubMed PMID: 24897520; PubMed
Central PMCID: PMC4045670.


43: Duan Y, Gu T, Zhang X, Jiang C, Yuan R, Li Z, Wang D, Chen X, Wu C, Chen Y,
Wu Y, Kong W. Negative effects of a disulfide bond mismatch in anti-rabies G
protein single-chain antibody variable fragment FV57. Mol Immunol. 2014
Jun;59(2):136-41. doi: 10.1016/j.molimm.2014.01.006. Epub 2014 Mar 2. PubMed
PMID: 24598312.


44: Zhang L, Jiang C, Zhang H, Gong X, Yang L, Miao L, Shi Y, Zhang Y, Kong W,
Zhang C, Shan Y. A novel modified peptide derived from membrane-proximal external
region of human immunodeficiency virus type 1 envelope significantly enhances
retrovirus infection. J Pept Sci. 2014 Jan;20(1):46-54. doi: 10.1002/psc.2587.
Epub 2013 Nov 19. PubMed PMID: 24254845.


45: Yuan R, Chen X, Chen Y, Gu T, Xi H, Duan Y, Sun B, Yu X, Jiang C, Liu X, Wu
C, Kong W, Wu Y. Preparation and diagnostic use of a novel recombinant
single-chain antibody against rabies virus glycoprotein. Appl Microbiol
Biotechnol. 2014 Feb;98(4):1547-55. doi: 10.1007/s00253-013-5351-6. Epub 2013 Nov
16. PubMed PMID: 24241896.


46: Zheng DD, Pan D, Zha X, Wu Y, Jiang C, Yu X. In vitro monitoring of the
formation of pentamers from the monomer of GST fused HPV 16 L1. Chem Commun
(Camb). 2013 Oct 4;49(76):8546-8. doi: 10.1039/c3cc44986f. PubMed PMID: 23945594.


47: Li X, Fan P, Jin J, Su W, An D, Xu L, Sun S, Zhang Y, Meng X, Gao F, Kong W,
Jiang C. Establishment of cell lines with increased susceptibility to EV71/CA16
by stable overexpression of SCARB2. Virol J. 2013 Aug 6;10:250. doi:
10.1186/1743-422X-10-250. PubMed PMID: 23919614; PubMed Central PMCID:
PMC3765843.


48: Zhang L, Miao L, Gong X, Zhang H, Yang L, Shi Y, Kong W, Jiang C, Shan Y.
Multiple antigen peptide mimetics containing gp41 membrane-proximal external
region elicit broad neutralizing antibodies against human immunodeficiency virus
type 1 in guinea pigs. J Pept Sci. 2013 Aug;19(8):491-8. doi: 10.1002/psc.2526.
Epub 2013 Jun 21. PubMed PMID: 23794478.


49: Sun B, Yu X, Yin Y, Liu X, Wu Y, Chen Y, Zhang X, Jiang C, Kong W.
Large-scale purification of pharmaceutical-grade plasmid DNA using tangential
flow filtration and multi-step chromatography. J Biosci Bioeng. 2013
Sep;116(3):281-6. doi: 10.1016/j.jbiosc.2013.03.015. Epub 2013 May 7. PubMed
PMID: 23660074.


50: Jin J, Ma H, Xu L, An D, Sun S, Huang X, Kong W, Jiang C. Development of a
Coxsackievirus A16 neutralization assay based on pseudoviruses for measurement of
neutralizing antibody titer in human serum. J Virol Methods. 2013
Feb;187(2):362-7. doi: 10.1016/j.jviromet.2012.11.014. Epub 2012 Nov 20. PubMed
PMID: 23178532.
社会兼职: 中华医学会医学病毒学委员会副主任委员
吉林省微生物学会常务理事
吉林省药学会生物制品委员会副主任委员

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