您的位置>>首页 > 师资队伍
师资队伍
万由衷
基本情况
姓名: 万由衷
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
Email:
详细情况
所在学科专业: 分子遗传学
所研究方向: 癌症发生和发展的分子机理
讲授课程: 癌症生物学
教育经历: 1994/09-1998/07 学士,生物化学和分子生物学,华中科技大学。

1998/09-2001/07 硕士,遗传学,复旦大学。

2003/09-2010/07 博士,遗传学,美国凯斯西储大学(Case Western Reserve University)。
工作经历: 2010/08-2014/10, 博士后研究员,哈佛大学医学院Dana-Farber癌症研究所。

2014/11- ,教授,吉林大学生命科学院。
科研项目: 2015/05-2020/05, 国家“青年千人计划”资助,RNA剪切因子突变在癌症中的作用。
学术论文: Sougnez C, Stewart C, Sivachenko A, Wang L, Wan Y, Zhang W, Shukla SA, Vartanov A, Fernandes SM, Saksena G, Cibulskis K, Tesar B, Gabriel S, Hacohen N, Meyerson M, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ. Evolution and impart of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013 152(4):714-26.

2. Wan Y, Wu CJ. SF3B1 mutations in chronic lymphocytic leukemia. Blood. 2013 121(23):4627-34.

3. Zhou H, Yu M, Fukuda K, Im J, Yao P, Cui W, Bulek K, Zepp J, Wan Y, Kim TW, Yin W, Ma V, Thomas J, Gu J, Wang JA, DiCorleto PE, Fox PL, Qin J, Li X. IRAK-M mediates Toll-like receptor/IL-1R-induced NFkB activation and cytokine production. EMBO J. 2013 32(4):583-96.

4. Yin W, Wan Y*, Kim TW, Yao P, Xiao H, Zhou H, Xiao J, Fox P, Li X. The kinase activity of interleukin-1 receptor associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and transcription. J Interferon Cytokine Res. 2012 31(5):415-22.

5. Wang L, Lawrence MS, Wan Y*, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, Deluca DS, Zhang L, Zhang W, Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, Cibulskis K, Tesar B, Sievers QL, Shefler E, Gabriel S, Hacohen N, Reed R, Meyerson M, Golub TR, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011 365(26):2497-506.

6. Wan Y, Kim TW, Yu M, Zhou H, Yamashita M, Kang Z, Yin W, Wang JA, Thomas J, Sen GC, Stark GR, Li X. The dual function of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production. J Immunol. 2011 186(5):2006-14.

7. Wan Y, Yang M, Kolattukkudy S, Stark GR, Lu T. Activation of camp-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells. J interferon Cytokine Res. 2010 30(9):677-81.

8. Gluen MF, Kang Z, Wan Y, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity. 2010 32(1):54-66.

9. Wan Y, Xiao H, Affolter J, Kim TW, Bulek K, Chaudhuri S, Carlson D, Hamilton T, Mazumder B, Stark GR, Thomas J, Li X. Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control. J Biol Chem. 2009 284(16):10367-75.

10. Kandel ES, Lu T, Wan Y, Agarwal MK, Jackson MW, Stark GR. Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB. Proc Natl Acad Sci. 2005 102(18):6425-30。
获奖情况: 2015, 国家“青年千人计划”

版权所有:吉林大学生命科学学院 2017 © 电话:+(86)-431-81969061

地址:吉林省长春市前进大街2699号生命科学楼 邮编:130012   Power by leeyc