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金英花
基本情况
姓名: 金英花
性别:
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
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详细情况
所在学科专业: 细胞生物学
所研究方向: 1)肿瘤细胞信号转导机制研究;2)抗肿瘤药物研发;3)人参皂苷人类靶点的发现
讲授课程: 1. 主讲“蛋白质与酶学”—生命科学学院3年级本科生专业课;
2. 主讲“现代生物学研究方法论” —生命科学学院研究生必修课;
教育经历: 1983年 9月-1988年 6月:吉林大学分子生物系理学学士;
1994年 9月-1996年 8月:首尔大学药学院药学硕士;
1996年 9月-2000年 8月:首尔大学药学院药学博士;
工作经历: 2000年 9月-2002年 8月:首尔大学综合药物研究所博士后;
2002年 9月-2002年11月:首尔大学综合药物研究所资深研究员;
2002年11月-2004年11月:清华大学生物科学与技术系;
2004年11月-今 : 吉林大学生命科学学院教授、博士生导师;
科研项目: 1. 国家自然科学基金面上项目(NSFC30370274),2004,1 - 2004,12;
2. 国家自然科学基金委主任基金(NSFC30640064),2007,1 - 2007,12;
3. 国家自然科学基金面上项目(NSFC30770447), 2008,1 - 2010,12;
4. 国家自然科学基金委重大研究计划项目(NSFC90813003), 2009,1 - 2011,12;
5. 国家自然科学基金面上项目(NSFC31070670),2011,1 - 2013,12;
6. 国家自然科学基金委主任基金(NSFC31240078),2013,1 - 2013,12;
7. 吉林大学引进学术带头人配套基金(2005);
8. 华人科学家普洱茶研究计划项目(2010);
9. 吉林省人民政府人才开发资助金 (2008年,一等)。
10. 吉林省人民政府人才开发资助金 (2013年,重点, 参与)
11. 吉林省发改委,“基于Annexin A2的原发性肝癌靶向药物的研发”(2017年)
12. 吉林大学省校共建自然科学类科研项目(2017年)
学术论文: 发表的部分文章
1.Yu-Shi Wang, He Li, Hongyan Zhu, Yang Li, Ying-Hua Jin* Identification of natural compounds targeting Annexin A2 with an anti-cancer effect Natural compounds targeting Annexin A2, Protein Cell, 2018 Mar 5. doi: 10.1007/s13238-018-0513-z
2.Yu-Shi Wang, Yingjia Lin, He Li, Yang Li, Zhiguang Song,Ying-Hua Jin* The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity Scientific Reports 7, 12408 (2017) doi:10.1038/s41598-017-12572-4
3. Yingjia Lin, Yang Li, Zhi-Guang Song, Hongyan Zhu, Ying-Hua Jin* The interaction of serum albumin with ginsenoside Rh2 (G-Rh2) resulted in the downregulation of G-Rh2 cytotoxicity J Ginseng Res 2017,41,330-338 (引用1次)
4. Yuan Shen, Shanshan Liu, Jiao Fan, Yinghua Jin,* , Baolei Tian, Xiaofei Zheng*, Hanjiang Fu*, Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC–p53 protein interactions EMBO Rep. 2017,18(4),536-548
5. Yang Li,Xiaokang Liu,Dan Jiang, Yingjia Lin,Yushi Wang,Qing Li,Linlin Liu ,Ying-Hua Jin* Betulin induces reactive oxygen species-dependent apoptosis in human gastric cancer SGC7901 cells Arch. Pharm. Res. 2016,39(9),1257-1265
6.Shanshan Liu, Juanjuan Zhu, Taifeng Jiang, Yiran Zhong, Yi Tie,Yongge Wu, Xiaofei Zheng Yinghua Jin* & Hanjiang Fu* Identification of lncRNA MEG3 Binding Protein Using MS2-Tagged RNA Affinity Purification and Mass Spectrometry,Appl Biochem Biotechnol 2015, 176, 1834-1845
7. Yingjia Lin,Dan Jiang,Yang Li,Xinye Han,Di Yu,Jeong Hill Park,Ying-Hua Jin*
Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells J Ginseng Res 2015,39,22-28 (34次)
8. Chun-Ying Liu, Rui-Xin Zhou, Chang-Kai Sun, Ying-Hua Jin, Hong-Shan Yu, Tian-Yang Zhang, Long-Quan Xu, Feng-Xie Jin. Preparation of minor ginsenosides C-Mc, C-Y, F2, and C-K fromAmerican ginseng PPD-ginsenoside using special ginsenosidase type-I from Aspergillus niger g.848. J Ginseng Res, 2015, 39:221-229
9.Xiao-Xi Guo, Yang Li, Chao Sun, Dan Jiang, Ying-Hua Jin* p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. Protein Cell 2014, 5, 224 – 234 (IF:5.3,被引22次)
10. Chao Sun, Xiaoxi Guo, Ying-Hua Jin* Apoptosis is Induced in Cancer Cells via the Mitochondrial Pathway by the Novel Xylocydine-Derived Compound JRS-15 Int. J. Mol. Sci. 2013, 14, 850-870

11. Xiaoxi Guo, Qiao Guo, Yang Li, Seung ki Lee*, Ying-Hua Jin*, Ginsenoside Rh2 induces human hepatoma cell apoptosis via Bax/Bak triggered cytochrome c release and caspase-9/-caspase-8 activation. Int. J. Mol. Sci. 2012, 13, 15523-15535

12. Ying Liu, Guo-Yan Zhang, Yang Li, Ya-Nan Zhang, Sheng-Ji An*, Ying-Hua Jin* Synthesis of Novel Amide Derivatives with In Vitro Antiproliferative and Cytotoxic Activity Heteroatom Chemistry 2013, 24, 9-17

13. Zhuo Zhan, Kan He, Yang Li, Ying-Hua Jin* Phosphorylation of Rad9 at Serine 328 by Cyclin A-Cdk2 Triggers Apoptosis via Interfering Bcl-xL. PLoS One. 2012, 7 (9) e44923.

14. Chuan Xiao§, Chao Sun§, Weiwei Han, Feng Pan, Yu Li, Zhi-Guang Song?, Ying-Hua Jin? Synthesis of 6-(het) ary Xylocydine Analogues and Evaluating their Inhibitory Activities of CDK1 and CDK2 in Vitro. Bioorg & Medi Chem. 2011,19, 7100-7110

15. Xiaoxi Guo, Hanna Kim, Yang Li, Hyungshin Yim, Seung Ki Lee*, Ying-Hua Jin?. Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis. Protein & Cell. 2011, 2, 543-553.

16. Qing Li, Yang Li, Xiaoyu Wang, Xuexun Fang, Kan He, Xiaoxi Guo, Zhuo Zhan, Chao Sun, and Ying-Hua Jin*, Cotreatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, Bax translocation, and cytochrome c release. Mol Carcinogen 2011, 50,760-769 (31次)

17. Yang Li , Kan He, Yinghui Huang, Daxin Zheng, Chang Gao, Lin Cui, and Ying-Hua Jin*, Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells. Mol Carcinogen 2010, 49, 630-640. (62次)

18. Yang Li, Taiyi Jared Shen, Chang Gao, Qing Li, Ying-Hua Jin* Caspase-9 Activation—Critical for Betulin-induced Apoptosis of Human Hepatoma Cells Chem Res Chin Univ, 2010, 26, 792-797

19. Jing-hua Li, Yue Chen, Jia-si Wang, Wei Kong, Ying-Hua Jin* Etoposide Induces Mitochondria-Associated Apoptotic Cell Death in Human Gastric Carcinoma Cells Chem Res Chin Univ, 2008, 24, 597-602.

20. Kan He, Yue Chen, Jing-Hua Li, Zhuo Zhan, Ying-Hua Jin*, CyclinA-Cdk2 phosphorylates BH3 only protein BAD in vitro and in vivo. Chem Res Chin Univ, 2007, 23, 567-570.

21. Ying-Hua Jin, Kye Jin Yoo, You Hui Lee, and Seung Ki Lee. Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the Cyclin A-Cdk2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J Biol Chem. 2000, 275, 30256-30263. (288次)

22. Ying-Hua Jin, JoonSeoK Choi, Jeong Hill Park, and Seung Ki Lee*. Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells. Carcinogenesis 2003, 24, 1767-1772.(31次)

23. Ying-Hua Jin, Hyungshin Yim, Jeong Hill Park, and Seung Ki Lee. Cdk2 activity is associated with depolarization of mitochondria membrane potential during apoptosis. Biochem Biophys Res Commun. 2003, 305, 974-980. (57次)

24. Hyungshin Yim, Ying-Hua Jin, Byoung Duck Park, Hye Jin Choi, and Seung Ki Lee Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49 truncated Cdc6 and apoptosis. Mol Biol. Cell 2003, 14, 4250-4259.

25. Hyungshin Yim, In Sun Hwang, Joon Seok Choi, Kwang-Hoon Chun, Ying Hua Jin, and Seung Ki Lee Cleavage of Cdc6 by Caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells J. Cell .Biol. 2006, 174, 77-88.

26. Joon-Seok Choi, Soona Shin, Ying-Hua Jin and Seung ki Lee Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis, Apoptosis, 2007, 12, 1229-1241

27. Ying-Hua Jin, Suk-Jin Lee, Myung Hee Chung, Jeong-Hill Park, Young-In Park, Tae Hyeong Cho and Seung-Ki Lee. Aloesin and Arbutin Inhibit Tyrosinase Activity in a Synergistic Manner via a Different Action Mechanism. Arch Pharm Res 1999, 22, 232-236 (72次)

28. Xiaoyu Xue, Haitao Yang, Wei Shen, Qi Zhao, Jun Li,Kailin Yang, Cheng Chen, Ying-Hua Jin, Mark Bartlam,and Zihe Rao Production of Authentic SARS-CoV M pro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction J. Mol. Biol. 2007,366, 965–975.
社会兼职: 中国细胞生物学学会理事;
吉林省细胞生物学学会副理事长;
中国化学会会员;
韩国分子、细胞生物学学会正会员;
高等化学学报审稿人;
国家自然科学基金项目评审专家;
科技部863项目评审专家;
北京市自然科学基金项目评审专家;
山东省自然科学基金项目评审专家;
国家留学基金评审专家;
教育部双语教学项目评审专家;
长江学者评审专家。
治学格言: 厚德载物!

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