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师资队伍
王迪
基本情况
姓名: 王迪
性别:
职称: 副教授
是否博导:
最高学历: 研究生
最高学位: 博士
Email:
详细情况
所在学科专业: 微生物及生化药学
所研究方向: 1.药物有效成分的分离与新药开发;2.药物药效及分子药理学研究;3.大型真菌菌株的诱变筛选及培养条件优化;4.药物的非破坏在线质量控制的研究与应用(近红外光谱定量分析法);
教育经历: 2009/09 – 2013/09,香港大学,李嘉诚医学院,研究生/博士;
2007/09 – 2009/06,吉林大学,生命科学学院,生物化学与分子生物学,研究生/硕士;
2003/09 – 2007/06,吉林大学,生命科学学院,生物科学专业,本科生/学士;
工作经历: 2013年09月~现在:吉林大学,生命科学学院,讲师
科研项目: 1. 国家自然科学基金青年项目,81402955,虫草素及甘草素定向合成产物CLCN促人肝癌细胞凋亡调控机制研究,2015/01-2017/12,23万元,在研,主持;
2. 吉林省重大科技攻关招标项目,20150203002NY,牛樟芝高产菌株液态深层发酵关键技术及产品研发,2015/01-2017/12,75万元,在研,主持;
3. 吉林省教育厅“十二五”科学技术研究项目,2014B033,蝙蝠蛾拟青霉治疗II型糖尿病及肾炎并发症药效药理机制研究,2015/01-2016/12,3万元,在研,主持;
4. 吉林省“双十工程”重大科技成果转化项目,20140301003YY,小牛脾提取物注射液技术提升与成果产业化,2014/01-2016/12,200万元,在研,参与人;
5. 吉林省“双十工程”重大科技成果转化项目,20130201006ZY,冬虫夏草菌的发酵粉关键技术攻关及产品开发(子课题),2013/12-2015/12,60万元,已结题,主持;
6. 吉林省发展与改革委员会项目,2013779,多西他赛白蛋白纳米粒的研发,2012/01-2014/12,,10万元,已结题,参与人
学术论文: 第一作者发表论文
1)Wang D, Wong HK, Zhang L, McAlonan GM, Wang XM, Sze SC, Feng YB, Zhang ZJ Not only dopamine D(2) receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 39:332-338, 2012.( IF: 4.02)
2)Wang D, Lu JH, Liu Y, Meng QF, Xie J, Wang ZZ, Teng LS*. Liquiritigenin induces tumor cell death through mitogen-activated protein kinase (MPAKs)-mediated pathway in hepatocellular carcinoma cells. BioMed Research International. vol. 2014, 11 pages, 2014. doi:10.1155/2014/965316 (IF: 1.579)
3)Wang D, Wong HK, Feng YB, Zhang ZJ*. Liquiritigenin exhibits antitumor action in pituitary adenoma cells via Ras/ERKs and ROS-dependent mitochondrial signaling pathways. Journal of pharmacy and pharmacology. 66, 408-417, 2013. (IF: 2.264)
4)Wang D, Wong HK, Feng YB, Zhang ZJ*. 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. Journal of Neuro-oncology. 116 (2):221-30, 2014. (IF: 3.07)
5)Wang D, Tan QR, Zhang ZJ* . Neuroprotective Effects of Paeoniflorin, But Not the Isomer Albiflorin, are Associated with the Suppression of Intracellular Calcium and Calcium/Calmodulin Protein Kinase II in PC12 Cells. Journal of Molecular Neuroscience. 51(2):581-90, 2013. (IF: 2.891)
6)Wang D, Wong HK, Feng YB, Zhang ZJ Paeoniflorin, a Natural Neuroprotective Agent, Modulates Multiple Anti-Apoptotic and Pro-apoptotic Pathways in Differentiated PC12 Cells. Cell Mol Neurobiol. 33: 521-529, 2013. (IF: 2.293)
7)Wang D, Lu CY, Teng LS, Guo ZH, Meng QF, Liu Y, Zhong LD, Wang W, Xie J*, Zhang ZJ*. Therapeutic effects of Chinese herbal medicine against neuroendocrinological diseases especially related to hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axis. Pakistan Journal of pharmaceutical sciences. 2014; 27 (3): 741-754. (IF: 0.658)
8)Wang D, Wang W, Zhou YL, Wang J, Jia DX, Wong HK, Zhang ZJ*. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neuroscience letters. 2015, 606: 60-65. (IF: 2.03)
联系人发表论文
9)Zhou YL, Guo ZH, Meng QF, Lu JH, Wang N, Liu H, Liang QM, Quan YT, Wang D*, Xie J. Cordycepin Affects Multiple Apoptotic Pathways to Mediate Hepatocellular Carcinoma Cell Death. Anti-Cancer Agents in Medicinal Chemistry. 2016. (Accepted) (IF: 2.469)
10)Chungang Liu, Xuerui Zeng, Yi Li, Hongli Ma, Jingjing Song, Yuhuan Li, Yulin Zhou, Robert J. Lee*, Di Wang*. Investigation of hypoglycemic, hypolipidemic and anti-inflammatory activities of Paecilomyces tenuipes N45 on streptozotocin-induced diabetic rats. Molecular Medicine Reports. 2016. (Accepted) (IF: 1.55 )
11)Song JJ, Wang YW, Liu CG, Lu JH, Meng QF, Liu Y, Wang J, Wang D* Cordyceps militaris Fruit Body Extract ameliorates membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via NF-κB pathway. Food & Function. 2016. [Epub ahead of print] (IF: 2.89 )
12)Song JJ, Wang YW, Teng MY, Zhang SQ, Yin MY, Lu JH, Liu Y, Lee RJ, Wang D*, Teng LS. Cordyceps Militaris Induces Tumor Cell Death via Caspase-dependent Mitochondrial Pathway in HepG2 and MCF-7 cells. Molecular Medicine Reports. 2016 (Proof) (IF: 1.554).
13)Wang J, Teng LR, Liu YG, Hu WJ, Chen WQ, Hu X, Wang YW, Di Wang*. Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepialid Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley rats. Journal of Diabetes Research. 2016. 2016(1):1-10 (IF: 2.1)
14)Wang D, Zhang YF, Lu JH, Wang Y, Wang JY, Meng QF, Lee RJ, Wang D*, Teng LS*. Cordycepin, a natural antineoplastic agent, induces breast cancer cells apoptosis via caspase-dependent mitochondrial pathway. Natural Product Communications. 2016, 11(1): 63-68. (IF: 0.906).
15)Hu S, Wang D, Zhang JR, Du MY, Cheng YK, Liu Y, Zhang N, Wang D*, Wu Y*. Mitochondria Related Pathway is Essential for Polysaccharides Purified from Sparassis Crispa Mediated Neuro-protection against Glutamate-induced Toxicity in Differentiated PC12 Cells. International Journal of Molecular Sciences. 2016, 17, 133; doi:10.3390/ijms17020133 (IF: 2.89)
16)Du LN#, Liu CG#, Meng QF, Lu JH, Zhou YL, Liu Y, Cheng YK, Wang D*, Teng LS Anti-diabetic Activities of fungi Paecilomyces tenuipes N45 Extract in alloxan-induced diabetic mice. Molecular Medicine Reports. 2016, 13(2): 1861-1868 (IF: 1.554).
17)Wang J#, Li LZ#, Teng LR, Lu JH, Xie J, Hu WJ, Liu Y, Liu Y, Wang D*, Teng LS. Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract. Molecular Medicine Reports. 2016, 13(2): 1701-1708 (IF: 1.554)
18)Song J, Xing GY, Cao JM, Teng LR, Li CL, Meng QF, Lu JH, Zhou YL, Liu Y, Wang D*, Teng LS*. Investigation of antidepression activities of exopolysaccharides obtained from Marasmius androsaceus fermentation in a mouse model. Molecular Medicine Reports. 2016, 13(1):939-946 (IF: 1.554).
19)Wang J, Song JJ, Wang D, Zhang N, Meng QF, Zhou YL, Wang N, Liu Y, Wang D *, Teng LS *. The anti-membranous glomerulonephritic activity of purified polysaccharides from Irpex lacteus Fr. (ILN10) International Journal of Biological Macromolecules, 2016, 84:87-93 (IF: 2.891)
20)Meng FX, Xing GY, Li YT, Song J, Wang YZ, Meng QF, Lu JH, Zhou YL, Liu Y, Wang D*, Teng LS, The Optimization of Marasmius androsaceus Submerged fermentation Conditions in Five-Liter Fermentor. Saudi Journal of Biological Sciences, 2016.33:S99-S105 (IF:1.257)
21)Quan Li#, Yanzhen Wang#, Guangsheng Cai, Fange Kong, Xiaohan Wang, Yang Liu, Xinyu Hu, Di Wang*, Lirong Teng*. Anti-fatigue Activity of Liquid Cultured Tricholoma matsutake Mycelium Partially via Regulation of Antioxidant Pathway in Mouse. BioMed Research International.. 2015, Article ID 562345, 10 pages, doi:10.1155/2015/562345 (IF: 1.597)
22)Hu S, Teng LR, Zhang JR, Meng JT, Zhuang Z, Du MY, Wang D*, Liao WW*. Mitochondria related pathway is essential for a novel synthetic compound-mediated neuro-protection in differentiated PC12 cells. Chem. Res. Chin. Univ. 2015,11: 2322-2328. (IF: 0.875)
23)Song JJ, Hou XT, Hu Xinyu, Lu CY, Liu CG, Wang J, Liu W, Teng LR, Wang D* , Not only serotonergic system, but also Dopaminergic System Involved in Albiflorin against Chronic Unpredictable Mild Stress-Induced Depression-like Behavior in Rats. Chemico-Biological Interactions. 2015, 242:211-217. (IF: 2.557)
24)Xing GY, Cao JM, Wang D, Song J, Lu JH, Meng QF, Yan GD, Wang D*, Teng LS * Near Infrared Spectroscopic (NIRS) Analysis of paclitaxel concentration in rat blood by Improved Chemometric Model. Combinatorial Chemistry & High Throughput Screening. 2015, 18 (7): 704-711. (IF:1.223).
25)Song JJ, Wang YW, Teng MY, Cai GS, Xu HK, Guo HX, Liu Y, Wang D*, Teng LS*. Studies on the Anti-fatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model. Evidence-based Complementary and Alternative Medicine. vol. 2015, Article ID 174616, 15 pages, 2015. (IF: 1.88)
26)李兰洲,张爽,王娟,滕利荣,曹尚,王迪*. 林蛙抗菌肽的制备及抑菌活性研究. 食品安全质量检测学报. 2015, 6(3):1067-1072 (核心)
27)王雪,刘燕阁,逯家辉,王春月,贾冰璇,孟庆繁,张洋,王迪*. 黄芩中抗菌有效成分提取工艺研究. 生物质化学工程. 2015, 49 (5):34-38. (核心)
28)Tian Ye, Teng LR, Wang ZZ, Zhao M, Meng QF, Lu JH, Tian JM, Zhang WW, Wang Di*, Teng LS*. Studies of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing Pill in rats. Experimental and Therapeutic Medicine. 2015, 9(6): 2349-2355. (IF: 1.279)
29)Wang D, Guo TQ , Wang ZY, Lu JH , Liu DP, Meng QF, Xie J, Liu Y, Zhang XL, Teng LS*. ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells. Brazilian Journal of Medical and Biological Research. 2014; 47(9): 773-779. (IF: 1.006)
30)Teng LS, Kou CJ, Lu CY, Xu JM, Xie J, Lu JH, Liu Y, Wang ZZ, Wang D*. Involvement of the ERK Pathway in Protective effects of Glycyrrhizic Acid against MPP+-Induced Apoptosis in Dopaminergic Cells. International Journal of Molecular Medicine. 2014; 34(3): 742-748. (IF: 2.088)
31)Dong Y, Jing TJ, Meng QF, Liu CG, Hu S, Ma YH, Liu Y, Lu JH, Cheng YK, Wang D* and Teng LR*. Studies on the Anti-diabetic Activities of Cordyceps Militaris Extract in Diet-Streptozotocin-Induced Diabetic Sprague-Dawley Rats. BioMed Research International. vol. 2014, Article ID 160980, 11 pages, 2014. doi:10.1155/2014/160980(IF: 1.579)
32)Song J, Xie J, Li CL, Lu JH, Meng QF, Yang ZG, Lee RJ, Wang D*, Teng LS*. Near Infrared Spectroscopic (NIRS) Analysis of Drug-Loading and Particle Size of Risperidone Microspheres by Improved Chemometric Model International Journal of Pharmaceutics. International Journal of Pharmaceutics, 2014, 472: 296-303 (IF: 3.65)
33)宋佳,李臣亮,邢高杨,孟庆繁,逯家辉,曹家铭,周毓麟,王迪*,滕利荣.径向基神经网络结合近红外光谱技术分析安络小皮伞发酵组分的研究. 光学学报. 2014,34(12):1230001. (EI)
34)滕伟卓,宋佳,孟凡欣,孟庆繁,逯家辉,胡爽,滕利荣,王迪*,谢晶*.采用近红外漫反射光谱进行蝙蝠蛾拟青霉菌丝体组分检测的研究. 光谱学与光谱分析. 2014, 34(10): 2645-2651. (IF: 0.292 )
35)Dong Y, Hu S, Liu CG, Meng QF, Song J, Li CL, Lu JH, Cheng YK, Wang D*, Teng LR*. Purification of polysaccharides from Cordyceps Militaris and their anti-hypoxia effect. Molecular Medicine Reports. 2015, 11(2):1312-1317. (IF:1.554)
36)Zhang N, Li Q, Wang J, Lu JH, Yang S, Xie J, Meng QF, Quan YT, Wang D*, Teng LR*. Screening of Irpex lacteus Mutant Strains and Optimizing Fermentation Conditions. Journal of Food, Agriculture & Environment. 2014, 12(2): 1213-1219.
37)Tian Y, Teng LR, Song JJ, Meng QF, Lu JH, Zhang WW, Wei K, Wang N, Wang D*, Teng LS*. Studies on the analgesic activities of Jia-Yuan-Qing Pill and its safety evaluation in mice. Protoplasma. 251(5):1245-53, 2014. (IF: 2.651)
38)Teng LS, Meng QF, Lu JH, Xie J, Liu Y, Wang ZZ, Wang D*. Liquiritin modulates ERKs and AKT/GSK-3beta-dependent pathways to protect glutamate-induced cell damage in differentiated PC12 cells. Molecular Medicine Reports. 2014, 10(2): 818-824. (IF:1.554)
非第一非联系人发表论文
39)Wei Wang, Dan-Dan Tian, Bin Zheng, Di Wang, Qing-Rong Tan, Chuan-Yue Wang, Zhang-Jin Zhang. Peony-Glycyrrhiza Decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Drug Metabolism&Disposition. 2015. 43(7):1147-53. (IF: 3.334)
40)Du LN, Liu Y, Meng QF, Song J, Wang D, Lu JH, Zhou YL, Teng LS*. Acute and subchronic toxicity studies on safety assessment of Paecilomyces tenuipes N45 extracts. Comb Chem High Throughput Screen. 2015, 18(8): 809-818. (IF: 1.223)
41)Zhang RY, Li X, Shi YN, Shao YF, Sun KX, Wang AP, Sun FY, Liu WH, Wang D, Jin JJ*, Li YX* . The Effects of LPM570065, a Novel Triple Reuptake Inhibitor, on Extracellular Serotonin, Dopamine and Norepinephrine Levels in Rats. PLoS ONE, 2014 9(3):e91775. doi: 10.1371/journal.pone.0091775 (IF: 3.23)
42)Zhang ZJ, Wang D, Man SC, Ng R, McAlonan GM, Wong HK, Wong W, Lee Jade, Tan QR. Platelet 5-HT1A receptor correlates with major depressive disorder in drugfree Patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2014;53:74-79. (IF: 3.689)
43)Zhang N, Wang D, Wang J, Lu JH, Meng QF and Teng LR*. Application of near infrared spectroscopy in quality control of Irpex lacteus. IET Conference Publications, 2012: 549-553, International Conference on Automatic Control and Artificial Intelligence, ACAI 2012. (EI)
44)Zhang ZJ, Tan QR, Tong Y, Wang XY, Wang HH., Ho LM, Wong HK., Feng YB, Wang D, Ng R, McAlonan GM, Wang CY, and Wong VT An epidemiological study of concomitant use of Chinese medicine and antipsychotics in schizophrenic patients: implication for herb-drug interaction, PLoS One 6, e17239, 2011. (IF: 4.092)

着作教材: 《药学综合实验教程》编委,41万字 出版社:吉林大学出版社
《吉林大学校园植物志》编委,15万字 出版社:吉林大学出版社
社会兼职: 吉林省生化与分子生物学会会员;
《食品工业科技》特约审稿专家、《重庆理工大学学报》特约审稿专家、《实用肿瘤学杂志》特约审稿专家、Chinese Medicine杂志审稿人。

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