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王迪
基本情况
姓名: 王迪
性别:
职称: 副教授
是否博导:
最高学历: 研究生
最高学位: 博士
Email:
详细情况
所在学科专业: 微生物及生化药学
所研究方向: 1.药物有效成分的分离与新药开发;2.药物药效及分子药理学研究;3.大型真菌菌株的诱变筛选及培养条件优化;4.药物的非破坏在线质量控制的研究与应用(近红外光谱定量分析法);
教育经历: 2009/09 – 2013/09,香港大学,李嘉诚医学院,研究生/博士;
2007/09 – 2009/06,吉林大学,生命科学学院,生物化学与分子生物学,研究生/硕士;
2003/09 – 2007/06,吉林大学,生命科学学院,生物科学专业,本科生/学士;
工作经历: 2013年09月~2015.09:吉林大学,生命科学学院,讲师
2015年09月~现在:吉林大学,生命科学学院,副教授
科研项目: 1.一种天麻多肽及制备方法和在抗菌抗病毒中的医用用途等四项专利申请权(项目负责人),2016.10-2035.10,150万元;在研;
2.水解蛋白注射液的二次开发(项目负责人),2016.9.8-2018.12.30, 60万元 (到账40万);
3.牛樟芝高产菌株液态深层发酵关键技术及产品研发(项目负责人),吉林省重大科技攻关招标项目, 2015.1-2017.12,75万元,在研;
4.虫草素及甘草素定向合成产物CLCN促人肝癌细胞凋亡调控机制研究(项目负责人),国家青年自然科学基金, 2015.1-2017.12,23万元,在研;
5.绣球菌高产菌株选育、深层发酵关键技术及产品开发(项目负责人), 吉林省重点科技攻关项目, 2016.1-2018.12,15万元,在研;
6.蛹虫草子实体水提物治疗Ⅱ型糖尿病及肾炎并发症的研究及产品研发(项目负责人),吉林省青年科研基金项目, 2016.1-2018.12,7万元,在研;
7.冬虫夏草菌的发酵粉关键技术攻关及产品开发(子项目负责人),吉林省“双十工程”重大科技成果转化项目,2013.12-2015.12,60万元,结题;
8.小牛脾提取物注射液技术提升与成果产业化(子项目负责人),2014.1-2016.12,40万元,结题;
学术论文: 近五年来,累计以第一责任作者(第一作者及联系人)身份发表SCI论文64篇,代表作如下:
第一作者发表论文
1)Wang D, Wong HK, Zhang L, McAlonan GM, Wang XM, Sze SC, Feng YB, Zhang ZJ Not only dopamine D(2) receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 39:332-338, 2012.( IF: 4.02)
2)Wang D, Wong HK, Feng YB, Zhang ZJ*. 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. Journal of Neuro-oncology. 116 (2):221-30, 2014. (IF: 3.07)
3)Wang D, Tan QR, Zhang ZJ* . Neuroprotective Effects of Paeoniflorin, But Not the Isomer Albiflorin, are Associated with the Suppression of Intracellular Calcium and Calcium/Calmodulin Protein Kinase II in PC12 Cells. Journal of Molecular Neuroscience. 51(2):581-90, 2013. (IF: 2.891)
联系人发表论文
4)Zhang XR, Chen YL, Cai GS, Li X, Wang D*. Carnosic acid induces apoptosis of hepatocellular carcinoma cells via ROS-mediated mitochondrial apoptosis pathway. Chemico-Biological Interactions. 2017, 277:91-100. (IF: 3.143)
5)Qu N, Robert J. Lee, Xie J, Wang D*, Teng LS*. Anticancer effects of cabazitaxel-loaded human serum albumin (HSA) nanoparticles. Journal of Controlled Release, 2017: 259 e5–e195 (IF: 7.786)
6)Li LZ, Teng MY, Liu YG, Qu YD, Zhang YZ, Lin F*, Wang D*. Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models. BioMed Research International 2017 (2017), Article ID 5852076, 9 pages. (IF: 2.476)
7)Zhuang JJ, Liu JS, Liu YG, Li HD*, Wang D*, Teng LS*, Enhanced proliferation inhibition of HL60 cells treated by synergistic all-trans retinoic acid/blue light/nanodiamonds. RSC Advances. 2017, 6: 38895-38901 (IF:3.108)
8)Lu WQ, Jia DX, An SS, Mu Ming, Qiao XN, Liu Y, Meng FX, Wang D*. Calf Spleen Extractive Injection Protects Mice against Cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 and ERK signaling. Scientific reports. 2017, 7: 8402. DOI:10.1038/s41598-017-08970-3 (IF: 4.259)
9)Li ZP, Chen X, Lu WQ, Zhang S, Guan X, Wang D*. Anti-Oxidative Stress Activity Is Essential for Amanita caesarea Mediated Neuroprotection on Glutamate-Induced Apoptotic HT22 Cells and an Alzheimer’s Disease Mouse Model. International Journal of Molecular Sciences 2017, 18: 1623. (IF:3.226)
10)An SS, Hu WJ, Zhang YF, Yuan Qingxia, Lu JH, Wang D*. Pharmacological Basis for Use of Armillaria mellea Polysaccharides in Alzheimer's Disease: Anti-apoptosis and Anti-oxidation. Oxidative Medicine and Cellular Longevity. 2017: Article ID 4184562, 11 pages (IF: 4.593).
11)Wang J, An, Li LZ, Liu YG, Huang XP, Liu CG, Teng LS, Wang D* Antidiabetic Activities of Polysaccharides Separated from Inonotus obliquus via the Modulation of Oxidative Stress in Mice with Streptozotocin-Induced Diabetes. PLOS ONE. 2017, 12(6):e0180476. (IF: 2.806)
12)Liu YG, Wang J, Li LZ, Hu WJ, Ding YP, Meng LN, Teng LR*, Wang D*. Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury. Oxidative Medicine and Cellular Longevity. 2017, Article ID 7841823, 12 pages. (IF: 4.593)
13)Zhang JR, An SS, Hu WJ, Teng MY, Qu YD, Zhang YZ, Yuan Y, Wang D* The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer’s Disease Mouse Model. International Journal of Molecular Sciences. 2016, 17:1810. (IF: 3.226)
14)Qu N, Lee RJ, Sun Y, Cai G, Wang J, Wang M, Lu J, Meng Q, Teng L, Wang D*, Teng LS* Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer. International Journal of Nanomedicine. 2016, 11:3451-3459 (IF:4.3)
15)Wang D, Zhang YF, Wang CY. Jia DX, Lu JH, Wang D*, Zhang Zhangjin*. 18 beta-Glycyrrhetinic Acid, a Novel Naturally Derived Agent, Suppresses Prolactin Hyperactivity and Reduces Antipsychotic-Induced Hyperprolactinemia in In Vitro and In Vivo Models. Neurochemical research, 2016. 41(9):2233-42 (IF: 2.581 )
16)Liu CG, Song JJ, Teng MY, Zheng XY, Li XM, Li YH, Tian Y, Pan ML, Lee RJ*, Wang D*. Antidiabetic and Antinephritic Activities of Aqueous Extract of Cordyceps militaris Fruit Body in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Oxidative Medicine and Cellular Longevity 2016. Article ID 9685257, 11 pages, doi:10.1155/2016/9685257 (IF: 4.593)
17)Song JJ, Wang YW, Liu CG, Lu JH, Meng QF, Liu Y, Wang J, Wang D* Cordyceps militaris Fruit Body Extract ameliorates membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via NF-κB pathway. Food & Function. 2016, 7: 2006-2015 (IF: 3.247)
18)Wang J, Teng LR, Liu YG, Hu WJ, Chen WQ, Hu X, Wang YW, Di Wang*. Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepialid Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley rats. Journal of Diabetes Research. 2016. 2016(1):1-10 (IF: 2.717)
19)Hu S, Wang D, Zhang JR, Du MY, Cheng YK, Liu Y, Zhang N, Wang D*, Wu Y*. Mitochondria Related Pathway is Essential for Polysaccharides Purified from Sparassis Crispa Mediated Neuro-protection against Glutamate-induced Toxicity in Differentiated PC12 Cells. International Journal of Molecular Sciences. 2016, 17, 133; doi:10.3390/ijms17020133 (IF: 3.226)
20)Wang J, Song JJ, Wang D, Zhang N, Meng QF, Zhou YL, Wang N, Liu Y, Wang D *, Teng LS *. The anti-membranous glomerulonephritic activity of purified polysaccharides from Irpex lacteus Fr. (ILN10) International Journal of Biological Macromolecules, 2016, 84:87-93 (IF: 3.671)
21)Meng FX, Xing GY, Li YT, Song J, Wang YZ, Meng QF, Lu JH, Zhou YL, Liu Y, Wang D*, Teng LS, The Optimization of Marasmius androsaceus Submerged fermentation Conditions in Five-Liter Fermentor. Saudi Journal of Biological Sciences, 2016.33:S99-S105 (IF:2.564)
22)Song JJ, Hou XT, Hu Xinyu, Lu CY, Liu CG, Wang J, Liu W, Teng LR, Wang D* , Not only serotonergic system, but also Dopaminergic System Involved in Albiflorin against Chronic Unpredictable Mild Stress-Induced Depression-like Behavior in Rats. Chemico-Biological Interactions. 2015, 242:211-217. (IF: 3.143)
23)Song J, Xie J, Li CL, Lu JH, Meng QF, Yang ZG, Lee RJ, Wang D*, Teng LS*. Near Infrared Spectroscopic (NIRS) Analysis of Drug-Loading and Particle Size of Risperidone Microspheres by Improved Chemometric Model International Journal of Pharmaceutics. International Journal of Pharmaceutics, 2014, 472: 296-303 (IF: 3.65)
24)Tian Y, Teng LR, Song JJ, Meng QF, Lu JH, Zhang WW, Wei K, Wang N, Wang D*, Teng LS*. Studies on the analgesic activities of Jia-Yuan-Qing Pill and its safety evaluation in mice. Protoplasma. 251(5):1245-53, 2014. (IF: 3.171)
着作教材: 《药学综合实验教程》编委,41万字 出版社:吉林大学出版社
《吉林大学校园植物志》编委,15万字 出版社:吉林大学出版社
社会兼职: 吉林省生化与分子生物学会会员;
《食品工业科技》、《重庆理工大学学报》、《实用肿瘤学杂志》特约审稿专家,Oncotarget、International Journal of Biological Macromolecules、Food & Function、Molecular Medicine Reports、Experimental and Therapeutic Medicine等杂志审稿人。

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