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李正强
基本情况
姓名: 李正强
性别:
职务: 副院长
职称: 教授
是否博导:
最高学历: 研究生
最高学位: 博士
电话:
Email:
详细情况
所在学科专业: 生物化学与分子生物学、生物物理学
所研究方向: 研究领域分支为酶学、结构生物学、分子生物物理学、无机-生物化学等。研究方向:酶学与酶组装技术。主要涉及:(1)血红素辅基酶(蛋白质)的结构表征及功能分子调控、结构模拟;(2)活性气体小分子与心脑血管功能调控的酶学基础;(3)酶与无机复合材料组装、功能及应用研究。
讲授课程: 结构生物学(本科)
生物物理学(本科)
生物科学与人类生存环境专题(本科,唐班)
酶工程(本科,唐班)
生物科学研究技术方法学及应用(研究生)
教育经历: 1984年06月 吉林大学理学学士(生物化学)
1990年06月 吉林大学理学硕士(生物化学)
1994年12月 吉林大学理学博士(物理化学)
工作经历: 1995-1996年 香港科技大学化学系 博士后
1997-1999年 吉林大学超分子结构与材料国家重点实验室副教授
2000-2001年 日本岗崎国立共同研究机构分子科学研究所 文教科学省外国人研究员
2001年9月 吉林大学分子酶学工程教育部重点实验室 教授
科研项目: 2012年以来承担的主要项目:
1.烷基化一氧化氮调控可溶性鸟苷酸环化酶的结构基础与分子机制研究
国家自然科学基金面上项目(31670797)2017.01-2020.12
2.印染用酶的分子改造研究
国家高技术研究发展计划“863”计划项目(2012AA022202B)2012.11-2015.12
学术论文: 2012年以来发表的主要论文
1.On the inherent properties of Soluplus? and its application in ibuprofen solid dispersions generated by microwave-quench cooling technology.
Pharm Dev Technol. 2016 Nov 8:1-48.
2.Chemical Coupling SERS Properties of Pyridine on Silver-Caged Metal Clusters M@Ag12
(M = V_, Nb_, Ta_, Cr, Mo, W, Mn+, Tc+, Re+)
Journal of ELECTRONIC MATERIALS DOI: 10.1007/s11664-016-4993-4
3.Structure advantage and peroxidase activity enhancement of deuterohemin-peptide–inorganic hybrid flowers
RSC Adv., (2016)6: 104265-104272
4.Proximal environment controlling the reactivity between inorganic sulfide and heme-peptide model
RSC Adv., (2016)6: 78858-78864
5.Entry of water into the distal heme pocket of soluble Guanylate Cyclase β1 H-NOX domain alters the ligated CO structure: A resonance Raman and in silico simulation study
RSC Adv., (2016)6: 43707-43714
6Nonresonant chemical mechanism in surface-enhanced Raman scattering of pyridine on M@Au12 clusters
Nanoscale, (2016) 8: 4086-4093
7.Amino acids-incorporated nanoflowers with an intrinsic peroxidase-like activity
Scientific Reports(2016) 6:22412
8.Clues for discovering a new biological function of Vitreoscilla hemoglobin in organisms: a potential sulfide receptor and storage
FEBS Letters (2016) 590 :1132–1142
9.Immobilization of Lactobacillus rhamnosus in mesoporous silica-based material:An efficiency continuous cell-recycle fermentation system for lactic acid production
Journal of Bioscience and Bioengineering (2016)6:645-651
10.Raman spectroscopic characteristics of diallyl trisulfide acting ontrans-crotonaldehyde
J. Raman Spectroscopy . (2015) 46:1067-1072
11.Construction and Characterization of Vitreoscilla Hemoglobin (VHb) with Enhanced Peroxidase Activity for Efficient Degradation of Textile Dye
J. Microbiol. Biotechnol. (2015), 25(9): 1433–1441
12. The process of S-nitrosation in sGC β1(1–194) revealed by infrared spectroscopy .
Journal of Molecular Structure. (2015)1089: 102–106.
13.Strong Core@Shell Dependence in Surface-Enhanced Raman Scattering of Pyridine on Stable 13-Atom Silver-Caged Bimetallic Clusters
J. Phys. Chem. C (2015)119: 17429?17437
14.UV-visible and Raman Spectroscopic Studies of Lithocholic Acid on E-2-Butenal for Anti-Glioma
Spectroscopy Letters:(2015) 48:506-513
15.The mechanism of N–Ag bonding determined tunability of surface-enhanced Raman scattering of pyridine on MAg (M = Cu, Ag, Au) diatomic clusters
Phys. Chem. Chem. Phys., (2014), 16: 20665—20671
16.Interactions of caveolin-1 scaffolding and intramembrane regions containing a CRAC motif with cholesterol in lipid bilayers
Biochimica et Biophysica Acta (2014) ,1838: 2588–2599
17.Resolution of 1,1,1-trifluoro-2-octanol by Pseudomonas sp. lipase encapsulated in aggregated silica nanoparticles
RSC Adv., (2014), 4: 6103-09
18.Spectroscopic Studies on the Interaction Between Aucubin and Bovine Serum Albumin without or with Copper II or Iron III
Spectroscopy Letters(2014) 47:119-130
19. “Fish-in-Net“, a Novel Method for Cell Immobilization of Zymomonas mobilis
PLOS ONE(2013) 11:e79569
20.pH-induced quaternary assembly of Vitreoscilla hemoglobin: The monomer exhibits better peroxidase activity,
BBA - Proteins and Proteomics (2013)1834: 2124-32
21.Theoretical investigation on the diatomic ligand migration process and ligand binding properties in non-O2-binding H-NOX domain
Proteins: Structure, Function and Bioinformatics (2013) 81:1363-76.
22.Characterization of the Interaction between Eupatorin and Bovine Serum Albumin by Spectroscopic and Molecular Modeling Methods.
Int J Mol Sci.(2013) 14:14185-203.
23.How does (E)-2-(acetamidomethylene)succinate bind to its hydrolase? From the binding process to the final result.
PLoS One. ( 2013)8:e53811.
24.Chemical Mechanism and Tunability of Surface-enhanced Raman Scattering of Pyridine on Heteronuclear Coinage Metal Diatomic Clusters: A Density Functional Study
J. Phys. Chem. C (2013)117: 12544?12551
25. Improving the properties of b-galactosidase from Aspergillus oryzae via encapsulation in aggregated silica nanoparticles
New.J.Chem., (2013), 37: 3793-3797
26.Improvement of the Enzyme Performance of Trypsin via Adsorption in Mesoporous Silica SBA-15: Hydrolysis of BAPNA
Molecules (2013) 18: 1138-1149
27.Molecular Dynamics Simulations Suggest Ligand’s Binding to Nicotinamidase/Pyrazinamidase
PLoS ONE (2012) 7:e39546
28. Hemoglobin immobilized with modified “fish-in-net” approach for the catalytic removal of aniline
Journal of Hazardous Materials(2012)217– 218:156-163
29. Combining the Physical Adsorption Approach and the Covalent Attachment Method to Prepare a Bifunctional Bioreactor
Int. J. Mol. Sci. (2012)13:11443-11454
着作教材: 常用酶活力测定方法 吉林大学出版社 2014年9月
酶工程 (第三版) 化学工业出版社 2016年5月
获奖情况: 吉林大学第四届师德先进个人(2015年)
2015年一名博士毕业生获得吉林省优秀博士论文奖
社会兼职: 中国生物物理学会理事
中国微生物学会酶工程专业委员会委员
吉林省生物质资源利用研究会副理事长
吉林省生物化学与分子生物学学会常务理事
吉林省食品学会常务理事
吉林省药学会保健食品专业委员会常务委员
治学格言: 不卑不亢 持之以恒 宁静致远 春华秋实

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