您的位置>>首页 > ENGLISH > FACULTY > 阅读正文
ENGLISH
JIN Yinhua

Professor Ying-Hua Jin
Tel/Fax: 0431-85155221 (Office);
Tel: 0431-85156278 (Lab);
E. Mail: yhjin@jlu.edu.cn;

 

Life Science Building, Jilin University, Qianjin Street No.2699,Changchun,P. R. China,

Postal Code:130012

Research Interests

   One of the most intriguing challenges in life science is to determine the molecular mechanisms by which cells survive for a given time, and then eventually come to death. Perturbation of the signaling cascades regulating cell survival and death may result in variety of human diseases such as cancer. The ultimate goal of our laboratory is to understand the common mechanism of cell death at the molecular level. Our research has the following specific objectives:
  1. to determine the mechanism for the cross-talk among the signaling pathways that regulate cell survival and death;
  2. to identify and characterize new genes and proteins that are associated with the cellular machinery for survival and death;
  3. to understand how cell death is associated with the pathogenesis of specific human cancer;
  4. to develop specific reagents and effective strategies for cancer therapy.
 

Representative papers

Major Publications
1. Xiao-Xi Guo, Yang Li, Chao Sun, Dan Jiang, Ying-Hua Jin* p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells. Protein Cell 2014, 5, 224 – 234
2. Chao Sun, Xiaoxi Guo, Ying-Hua Jin* Apoptosis is Induced in Cancer Cells via the Mitochondrial Pathway by the Novel Xylocydine-Derived Compound JRS-15  Int. J. Mol. Sci. 2013, 14, 850-870
3. Ying Liu, Guo-Yan Zhang, Yang Li, Ya-Nan Zhang, Sheng-Ji An*, Ying-Hua Jin* Synthesis of Novel Amide Derivatives with In Vitro Antiproliferative and Cytotoxic Activity Heteroatom Chemistry 2013, 24, 9-17
4. Xiaoxi Guo, Qiao Guo, Yang Li, Seung ki Lee*, Ying-Hua Jin*, Ginsenoside Rh2 induces human hepatoma cell apoptosis via Bax/Bak triggered cytochrome c release and caspase-9/-caspase-8 activation. Int. J. Mol. Sci. 2012, 13, 15523-15535
5. Zhuo Zhan, Kan He, Yang Li, Ying-Hua Jin* Phosphorylation of Rad9 at Serine 328 by Cyclin A-Cdk2 Triggers Apoptosis via Interfering Bcl-xL. PLoS One. 2012, 7 (9) e44923.
6. Chuan Xiao, Chao Sun, Weiwei Han, Feng Pan, Yu Li, Zhi-Guang Song, Ying-Hua Jin Synthesis of 6-(het) ary Xylocydine Analogues and Evaluating their Inhibitory Activities of CDK1 and CDK2 in Vitro. Bioorg & Medi Chem. 2011,19, 7100-7110
7. Xiaoxi Guo, Hanna Kim, Yang Li, Hyungshin Yim, Seung Ki Lee*, Ying-Hua Jin. Cdk2 acts upstream of mitochondrial permeability transition during paclitaxel-induced apoptosis. Protein & Cell. 2011, 2, 543-553.
8. Qing Li, Yang Li, Xiaoyu Wang, Xuexun Fang, Kan He, Xiaoxi Guo, Zhuo Zhan, Chao Sun, and Ying-Hua Jin*, Cotreatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer  cells in association with enhanced capsase-8 activation, Bax translocation, and cytochrome c release.  Mol Carcinogen 2011, 50,760-769
9. Yang Li , Kan He, Yinghui Huang, Daxin Zheng, Chang Gao, Lin Cui, and Ying-Hua Jin*, Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells.  Mol Carcinogen 2010, 49, 630-640.
10. Yang Li, Taiyi Jared Shen, Chang Gao, Qing Li, Ying-Hua Jin* Caspase-9 Activation-Critical for Betulin-induced Apoptosis of Human Hepatoma Cells  Chem Res Chin Univ, 2010, 26, 792-797.
11. Jing-hua Li, Yue Chen, Jia-si Wang, Wei Kong, Ying-Hua Jin* Etoposide Induces Mitochondria-Associated Apoptotic Cell Death in Human Gastric Carcinoma Cells  Chem Res Chin Univ, 2008, 24, 597-602.
12. Kan He, Yue Chen, Jing-Hua Li, Zhuo Zhan, Wei Kong, Ying-Hua Jin*, Cyclin A-Cdk2 Phosphorylates BH3 only Protein Bad in vitro  and in vivo, Chem Res Chin Univ, 2007, 23, 567-570
13. Ying-Hua Jin, Kye Jin Yoo, You Hui Lee, and Seung Ki Lee*. Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the Cyclin A-Cdk2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J Biol Chem. 2000, 275, 30256-30263.
14. Ying-Hua Jin, JoonSeoK Choi, Jeong Hill Park, and Seung Ki Lee*. Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells. Carcinogenesis 2003, 24, 1767-1772.
15. Ying-Hua Jin, Hyungshin Yim, Jeong Hill Park, and Seung Ki Lee*. Cdk2 activity is associated with depolarization of mitochondria membrane potential during apoptosis. Biochem Biophys Res Commun. 2003, 305, 974-980.
16. Hyungshin Yim, Ying-Hua Jin, Byoung Duck Park, Hye Jin Choi, and Seung Ki Lee* Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49 truncated Cdc6 and apoptosis. Mol Biol. Cell 2003, 14, 4250-4259.
17. Joon-Seok Choi, Soona Shin, Ying-Hua Jin and Seung ki Lee Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis, Apoptosis, 2007, 12, 1229-1241.
18. Hyungshin Yim, In Sun Hwang, Joon Seok Choi, Kwang-Hoon Chun, Ying-Hua Jin, and Seung Ki Lee* Cleavage of Cdc6 by Caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells J. Cell .Biol. 2006, 174, 77-88.
19. Xiaoyu Xue, Haitao Yang, Wei Shen, Qi Zhao, Jun Li,Kailin Yang, Cheng Chen, Yinghua Jin, Mark Bartlam,and Zihe Rao* Production of Authentic SARS-CoV M pro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction J. Mol. Biol. (2007) 366, 965–975.
20. Ying-Hua Jin, Suk-Jin Lee, Myung-Hee Chung, Jeong-Hill Park, Young-In Park, Tae Hyeong Cho, and Seung-Ki Lee*, Aloesin and Arbutin Inhibit Tyrosinase Activity in a Synergistic Manner via a Different  Action Mechanism.  Arch Pharm Res 1999, 22, 232-236

 

 

版权所有:吉林大学生命科学学院 2017 © 电话:+(86)-431-81969061

地址:吉林省长春市前进大街2699号生命科学楼 邮编:130012   Power by leeyc